Association of Genetic Variants in Alcohol Dehydrogenase 4 With Alcohol Dependence in Brazilian Patients

Guindalini, Camila; Scivoletto, Sandra; Ferreira, Ricardo G.m.; Breen, Gerome; Zilberman, Monica L.; Peluso, Marco Aurélio Monteiro; Zatz, Mayana

doi:10.1176/appi.ajp.162.5.1005

Cited by 57 publications

(57 citation statements)

References 11 publications

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“…Recently, several genes have been associated with the risk for alcoholism, including GABRA2 (Covault et al, 2004;Edenberg et al, 2004;Fehr et al, 2006;Lappalainen et al, 2005), ADH4 Guindalini et al, 2005;Luo et al, 2005b), and CHRM2 (Luo et al, 2005a;Wang et al, 2004), and their role in alcoholism susceptibility has been confirmed in multiple studies. Additional genes have also been implicated in disease risk, including GABRG3 ) and a bitter taste receptor, TAS2R16 (Hinrichs et al, 2006).…”

mentioning

confidence: 96%

Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol‐O‐methyltransferase

Foroud

Wetherill

Dick

et al. 2007

Alcoholism Clin & Exp Res

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Objective: To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking.Methods: Single nucleotide polymophisms (SNPs) were genotyped in a sample of 219 multiplex alcohol-dependent families of European American descent from the Collaborative Study on the Genetics of Alcoholism (COGA). Family-based tests of association were performed to evaluate the evidence of association between the 18 SNPs distributed throughout COMT, including the functional Val158Met polymorphism, and the phenotypes of alcohol dependence, early onset alcohol dependence, habitual smoking, and comorbid alcohol dependence and habitual smoking.Results: No significant, consistent evidence of association was found with alcohol dependence, early onset alcohol dependence, habitual smoking or the comorbid phenotype. There was no evidence that the functional Val158Met polymorphism, previously reported to be associated with these phenotypes, was associated with any of them.Conclusion: Despite the substantial size of this study, we did not find evidence to support an association between alcohol dependence or habitual smoking and variation in COMT.

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confidence: 96%

Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol‐O‐methyltransferase

Foroud

Wetherill

Dick

et al. 2007

Alcoholism Clin & Exp Res

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“…Nevertheless, several genes have been associated with a risk for alcoholism in studies that have been replicated, e.g. GABRA2 (Covault et al, 2004;Edenberg et al, 2004;Fehr et al, 2006;Lappalainen et al, 2005), ADH4 Guindalini et al, 2005;Luo et al, 2005a), and CHRM2 (Luo et al, 2005b;Wang et al, 2004). It is evident, however, that there are other genes that also influence the risk for alcoholism.…”

mentioning

confidence: 99%

Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains

Carr

Kimpel

Liang

et al. 2007

Alcoholism Clin & Exp Res

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Background-A highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP and iNP rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains.

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“…The presence or absence of Gene × Environment interactions may be partially related to differences in the strength of the associations of the ADH variants with alcohol dependence. The current evidence is inconsistent for the association of rs1800759 with alcohol-related phenotypes (Edenberg et al, 2006;Guindalini et al, 2005;Luo et al, 2005;Preuss et al, 2011), suggesting a weaker association for this variant. In our study, rs1229984 showed evidence of a main-effect-only relationship with maximum drinks and alcohol dependence symptoms.…”

Section: Discussionmentioning

confidence: 81%

“…Edenberg et al (1999) reported that the ADH4-rs1800759 C allele has lower promoter activity than the A allele, suggesting a greater risk for alcohol dependence for C allele carriers. Rs1800759 has been associated with alcohol dependence in some samples (Guindalini et al, 2005;Luo et al, 2006;Preuss et al, 2011) but not in others (Edenberg et al, 2006;Luo et al, 2005). This could be because of differences in the characteristics for the samples studied (e.g., case-control samples recruited from clinical populations versus familybased samples; Preuss et al, 2011).…”

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confidence: 99%

Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

Chartier

Dick

Almasy

et al. 2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. Method: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism. Genetic markers included ADH1B-rs1229984, ADH1B-rs2066702, ADH1C-rs698, ADH4-rs1042364, and ADH4-rs1800759. Phenotypes were maximum drinks consumed in a 24-hour period and total number of alcohol dependence symptoms according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Religious involvement was defined by self-reported religious services attendance. Results: Both religious involvement and ADH1B-rs1229984 were negatively associated with the number of maximum drinks consumed and the number of lifetime alcohol dependence symptoms endorsed. The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms. Risk variants had weaker associations with maximum drinks and alcohol dependence symptoms as a function of increasing religious involvement. Conclusions: This study provided initial evidence of a modifying effect for religious involvement on relationships between ADH variants and maximum drinks and alcohol dependence symptoms. (J. Stud. Alcohol Drugs, 77, 393-404, 2016)

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Association of Genetic Variants in Alcohol Dehydrogenase 4 With Alcohol Dependence in Brazilian Patients

Cited by 57 publications

References 11 publications

Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol‐O‐methyltransferase

Lack of Association of Alcohol Dependence and Habitual Smoking With Catechol‐O‐methyltransferase

Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains

Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms

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