2013
DOI: 10.3892/br.2013.190
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Association of genetic variants of the α-kinase 1 gene with myocardial infarction in community-dwelling individuals

Abstract: Abstract. We previously demonstrated that rs2074380 (G→A, Gly870Ser) and rs2074381 (A→G, Asn916Asp) of the α-kinase 1 gene (ALPK1) were significantly associated with chronic kidney disease (CKD) in individuals with diabetes mellitus. As CKD is a significant risk factor for coronary heart disease, we hypothesized that rs2074380 and rs2074381 of ALPK1 may contribute to the genetic susceptibility to myocardial infarction (MI) through affecting the susceptibility to CKD. The aim of the present study was to investi… Show more

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Cited by 15 publications
(12 citation statements)
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“…As a complex disease, CHD was hypothesized to be caused by both genetic and environmental factors [2]. The risk factors of CHD include hypercholesterolemia, hypertension, smoking, diabetes and lack of physical exercise [3].…”
Section: Introductionmentioning
confidence: 99%
“…As a complex disease, CHD was hypothesized to be caused by both genetic and environmental factors [2]. The risk factors of CHD include hypercholesterolemia, hypertension, smoking, diabetes and lack of physical exercise [3].…”
Section: Introductionmentioning
confidence: 99%
“…In China, CHD has affected more than 10 million people [4]. CHD is thought to be a complex disease resulting from the interaction between genetic and environmental factors [5]. The risk factors of CHD include hypertension, diabetes, lifestyle and clinical indicators (the level of cholesterol, triglyceride and uric acid) [6].…”
Section: Introductionmentioning
confidence: 99%
“…In China, CHD has affected more than 10 million people [4]. CHD is a complex disease resulting from the interactions between genetic and environmental factors [5]. The risk factors of CHD include hypertension, diabetes, lifestyle and clinical indicators (the level of cholesterol, triglyceride and uric acid) [6].…”
Section: Introductionmentioning
confidence: 99%