Association of Genetic Variants with Chronic Kidney Disease in Japanese Individuals

Abstract

Background and objectives: Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition have remained uncharacterized. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals.Design, setting, participants, & measurements: The study population comprised 5217 Japanese individuals (2955 men, 2262 women), including 778 subjects (480 men, 298 women) with CKD [estimated GFR (eGFR), <50 ml min ؊1 1.73 m ؊2 ] and 4439

Downregulation of uncoupling protein-2 by genipin exacerbates diabetes-induced kidney proximal tubular cells apoptosis

“…9 Several genetic studies have investigated the relationship between UCP2 gene polymorphism and susceptibility for the development of renal damage in humans. 10,11 Di Castro et al 12 found that UCP2 is a critical protein to prevent oxidative stress damage in renal mesangial cells in the context of hypertension. However, the role and mechanisms of UCP2 in tubular cell injury caused by hyperglycemia remain unknown.…”

Analysis of the association of an MMP1 promoter polymorphism and transcript levels with chronic periodontitis and end-stage renal disease in a Brazilian population

“…It was observed in Japanese subjects that the MMP1-1607*1G allele was significantly associated with CKD 53 and with CKD in individuals with a low serum concentration of HDL-cholesterol. 54 Interestingly, with regard to periodontal indices, we found that the MMP1*1G was associated with PI in groups without CKD.…”

Association of genetic variants with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus

“…a total of 150 polymorphisms (data not shown) were selected by genome-wide association studies of ischemic stroke and myocardial infarction (p-value for allele frequency <1.0x10 -7 ) with the use of the Genechip human mapping 500K array Set (affymetrix, Santa clara, ca, uSa) (14). the relationship of these polymorphisms to cKd was not previously examined in our studies (9)(10)(11)(12)15,16).…”