Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Karimi, Mohammad Hossein; Motazedian, Maryam; Abedi, Fariba; Yaghobi, Ramin; Geramizadeh, Bita; Nikeghbalian, Saman

doi:10.1016/j.gene.2012.04.055

Cited by 14 publications

(7 citation statements)

References 32 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The importance of ethnicity was also reported. The results of this study re-emphasize the importance of human genetic SNPs on the initiating and complicating clinical outcomes in transplant recipients, as presented in earlier reports (55)(56)(57). However, this study suffered limitations about the size and the type of samples that should be considered in the evaluation of results.…”

Section: Discussionsupporting

confidence: 71%

Evaluation of microRNA Gene Polymorphisms in Liver Transplant Patients with Hepatocellular Carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Genetic polymorphism in the miRNA sequence might alter miRNA expression and/or maturation, which is associated with the development and progression of hepatocellular carcinoma (HCC) in liver transplant patients. Objectives: Therefore, the prevalence of miRNA-146a G > C (rs2910164), miRNA-499A > G (rs3746444), miRNA-149C > T (rs2292832), and miRNA-196a-2 C > T (rs11614913) gene polymorphisms was evaluated in liver recipients with HCC with or without experiencing graft rejection. Methods: In a cross-sectional study, tissue samples were collected from 60 HCC patients who underwent liver transplant surgery at Namazi Hospital, Shiraz, Iran, in 2013 - 2015. A control group consisting of 120 individuals was randomly selected, as well. The genomic DNA was extracted from collected tissues and blood samples. The miRNA-146a (rs2910164), miRNA-499 (rs3746444), miRNA-149 (rs2292832), and miRNA-196a-2 (rs11614913) gene polymorphisms were evaluated in patients with HCC using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The CC genotype and C allele of the miRNA-146a (rs2910164) polymorphism were significantly associated with the increased risk of transplant rejection in patients with HCC (P = 0.05 and P = 0.05, respectively). The CC genotype and C allele of the miRNA-146a (rs2910164) were also significantly more frequent in male liver transplant patients who experienced acute rejection than in non-rejected ones (P = 0.05 and P = 0.03, respectively). However, no significant association was found between the genotypes and alleles of miRNA-499 (rs3746444), miRNA-149 (rs2292832), and miRNA-196a-2 (rs11614913) polymorphisms and HCC outcomes in liver transplant recipients. Conclusions: The importance of the CC genotype and C allele of the miRNA-146a (rs2910164) polymorphism in increasing the risk of transplant rejection was confirmed, but it needs further studies in larger populations.

show abstract

Section: Discussionsupporting

confidence: 71%

Evaluation of microRNA Gene Polymorphisms in Liver Transplant Patients with Hepatocellular Carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kwekkeboom and colleagues found that recipient CTLA-4 +49 G/G genotype is associated with reduced acute rejection after liver transplantation 25. Similarly, Karimi et al also found increased A allele prevalence in rejectors after liver transplantation in Iranian patients 39. Such results seemed to be unexplainable by previous studies.…”

Section: Discussionmentioning

confidence: 94%

Recipient Cytotoxic T Lymphocyte Antigen 4 +49 Single-Nucleotide Polymorphism Is Not Associated with Acute Rejection after Liver Transplantation in Chinese Population

Zhao¹,

Chen²,

Feng³

et al. 2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

Objective: Single-nucleotide polymorphisms (SNPs) in Cytotoxic T lymphocyte antigen 4 (CTLA-4) gene have been detected and proved to associate with the incidence of rejection after transplantation. However, previous studies gained inconsistent results about the association between CTLA-4 +49 single-nucleotide polymorphism and susceptibility of allograft rejection. Therefore we sought to clarify whether CTLA-4 +49 SNP influences the incidence of acute rejection after liver transplantation in Chinese population. Methods: Genomic DNA from 335 liver transplant recipients was genotyped for CTLA-4 +49 SNP by DNA sequencing. Acute rejection was confirmed by pathologic evidences. The association between CTLA-4 +49 SNP and incidence of acute rejection was then analyzed by dominant, recessive, codominant and overdominant models. Results: The incidence of acute rejection within the first 3 months was 11.9%. In acute rejectors, the frequency was 45% for G/G, 10% for A/A and 45% for A/G respectively, compared with 47.5% for G/G, 10.8% for A/A and 41.7% for A/G in non-acute rejectors. And no significant difference of allele distribution between these 2 groups was detected. Conclusions: This study suggests that CTLA-4 +49 SNP is not associated with acute rejection after liver transplantation in Chinese population.

show abstract

“…The most commonly studied CTLA-4 single nucleotide polymorphisms (SNPs) are promoter -318 C.T and exon 1+49 A.G, of which the A allele CTLA+49 A.G gene polymorphism was reported as a risk allele in liver transplant patients. 5 In contrast, the T-allele CTLA-4-318 gene polymorphism was associated with reduced AR in kidney transplant. 14 Several researchers have examined whether genetic polymorphisms in the CTLA-4 gene are associated with various conditions such as autoimmune diseases.…”

Section: Articlementioning

confidence: 96%

“…31 There are several polymorphisms in the CD28 gene that may affect the intensity of T-cell-mediated immunity, resulting in various autoimmune diseases and the occurrence of posttransplant allograft rejection. 5,10 Moreover, CD28 gene polymorphism affects the inhibitory/activating functions of CD28. 32 The position of CTLA-4, CD28, ICOS, and PD-1 in chromosome 2 is shown in Figure 1.…”

Section: Articlementioning

confidence: 99%

“…The CD28, CTLA-4, inducible costimulator (ICOS), and programmed cell death 1 (PD-1) are members of the T-cell regulatory molecular family located close to each other on the chromosome region 2q33-37. 5 In addition, it was shown that CTLA-4 and ICOS genes are associated with susceptibility to several autoimmune diseases such as type 1 diabetes, celiac disease, and multiple sclerosis. [6][7][8] As a result, several investigations have…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

Niknam

Karimi²,

Geramizadeh³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Costimulatory molecules are important factors determining the outcome of transplant. The aim of the present study was to investigate the effect of CTLA-4, CD28, PD-1, and ICOS gene polymorphisms on the outcome of kidney transplant. Materials and Methods: A total of 172 kidney transplant recipients were included in this study. There were 45 recipients (26%) who experienced acute rejection. The CTLA-4, PD-1, ICOS, and CD28 gene polymorphisms were evaluated by polymerase chain reaction and restriction fragment length polymorphism methods. Results: There were no differences between kidney transplant recipients with or without acute rejection in the distribution of genotypes and alleles of studied costimulatory molecules. Significant associations were observed between the AA genotype and the A allele of CTLA-4 1661 (P = .04, P = .05) and also CT and TT genotypes of PD-1.9 in the male compared with female subgroup of patients, with low frequency in the acute rejection group (P = .03; P = .04). Significant associations were observed between the AA genotype and the A allele of CTLA-4 -1661 (P = .02; P = .01) and also GA genotype of PD-1.3 (P = .03) in the male subgroup compared with female subgroup with low frequency of acute rejection. A significant association was observed between TC genotype of CD28 in the female compared with male subgroup of patients with high frequency of acute rejection (P = .05). Conclusions:The above results suggest that genetic polymorphisms of costimulatory molecules function as sex-dependent risk factors for development of acute rejection. Further studies are needed in different populations.

show abstract

Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients

Cited by 14 publications

References 32 publications

Evaluation of microRNA Gene Polymorphisms in Liver Transplant Patients with Hepatocellular Carcinoma

Evaluation of microRNA Gene Polymorphisms in Liver Transplant Patients with Hepatocellular Carcinoma

Recipient Cytotoxic T Lymphocyte Antigen 4 +49 Single-Nucleotide Polymorphism Is Not Associated with Acute Rejection after Liver Transplantation in Chinese Population

Untitled

Contact Info

Product

Resources

About