Association of glutathione S-transferase <i>GSTM1</i> and <i>GSTT1</i> deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis

Almoshabek, Hamoud A; Mustafa, Muhammad; Al-Asmari, Mohammed M; Alajmi, Tahani K; Alasmari, Abdulrahman

doi:10.1177/2048004016669645

Cited by 9 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is not a lot of study about these association, while Almoshabek and al. reported in young age Saudis that frequencies of GSTM1-active/GSTT1-null (OR = 2.70; p < 0.001) and GSTM1-null/GSTT1-null (OR = 2.43, p = 0.018) were significantly higher in overweight/obese as compared to normal weight [55]. Our results are in accordance with those of Afrand and al.…”

Section: Discussionsupporting

confidence: 92%

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Sombié

Sorgho

Kologo³

et al. 2020

BMC Med Genet

View full text Add to dashboard Cite

Background: Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks factors that may be associated with many types of disease processes such as cancer, diabetes, and hypertension. In the present study, we characterize the null genotypes of GSTM1 and GSTT1 in order to investigate the association between them and the risk of developing essential hypertension. Methods: We conducted a case-control study in Burkina Faso, including 245 subjects with essential hypertension as case and 269 control subjects with normal blood pressure. Presence of the GSTT1 and GSTM1 was determined using conventional multiplex polymerase chain reaction followed by gel electrophoresis analysis. Biochemical parameters were measured using chemistry analyzer CYANExpert 130.

show abstract

Section: Discussionsupporting

confidence: 92%

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Sombié

Sorgho

Kologo³

et al. 2020

BMC Med Genet

View full text Add to dashboard Cite

show abstract

“…It is important to note that there is a lack of information regarding these genotypes among children with obesity. However, studies in adults suggest that the null genotype of GST-M and GST-T may be associated with a higher risk of obesity 26,32,33 . Results of the current study revealed a signi cant deviation from Hardy-Weinberg proportion in GST-M and GST-T genotype distributions among children who suffer from obesity, with relatively higher null genotypes.…”

Section: Discussionmentioning

confidence: 99%

Do GST-M, GST-T, and TP53 Gene Polymorphisms Have a Role in Childhood Obesity?

Dirican,

Bulus,

Husseini

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective: This study investigates genotypic variations in GST-M, GST-T, and TP53;rs1042522 among children with obesity. Methods: Blood samples from 60 patients with childhood obesity were analyzed. Deletions in GST-M and GST-T were identified using quantitative PCR with melting curve analysis, while TP53;rs1042522 was genotyped via sequence analysis. Deviation from Hardy-Weinberg proportion was examined, and associations with clinical and demographic variables were assessed. Results: We observed deviations in the genotypes of GST-M and GST-T, while TP53;rs1042522 remained aligned. Higher cholesterol, LDL, and GGT levels were found in individuals with null GST-M genotypes. Notably, individuals with Wt/null GST-T genotypes had remarkably higher waist circumference and levels of albumin. The wild-type GST-T genotype correlated with reduced BMI and creatinine levels. Individuals with TP53;rs1042522 mutations showed decreased LDL and cholesterol levels but increased ALT levels. Conclusion: The research highlighted the notable influence of genetic variations in GST-M and GST-T on obesity in children, while the TP53 polymorphism, rs1042522, did not show a significant impact.

show abstract

“…But none of these provides a precise explanation of the process that underlies obesity. The significance of genetics in obesity has been clearly shown by research on ethnic prevalence, family aggregation, twins, and adoption [1,2]. The etiopathology of obesity has been linked to several risk factors, including both genetic and environmental ones [3,4].…”

Section: Introductionmentioning

confidence: 99%

An Assessment of Glutathione-S-Transferase and Lipid Profile in Obese Iraqi Patients

Adnan Mohammed,

Muqdad Khaleel

2024

IHJPAS

View full text Add to dashboard Cite

Obesity is a chronic disease that may have genetic, environmental, and other causes. Obesity is a shortcut to many diseases, such as hypertension, diabetes, atherosclerosis, and other chronic diseases. Oxidative stress increases obesity through free radicals. Glutathione S-transferase (GST) is a metabolic enzyme used to remove toxins. This study aimed to determine GST activity in obese patients as a predictor of oxidative stress and the effectiveness of lipid profiling in obese patients. The study included 139 samples of obese and healthy people (obese group 84 and healthy group 55). Both groups (obese and healthy groups) were divided into four groups based on body mass index. Blood samples were collected from obese males and females in Al-Yarmouk Hospital. Some biochemical parameters were measured for all study groups, including estimation of lipid profile, FSG, and GST activity. Results have shown a significant increase in low-density lipoprotein cholesterol (LDL-C) in obese groups and showed a rise in GST levels in healthy groups compared with obese groups (p < 0.05). These studies show that being overweight or obese makes you more likely to get heart disease and other illnesses. It has been demonstrated that the slightly lower levels of GST in the overweight and obese groups compared to other groups demonstrate the precise role of GST in its decrease with weight gain, along with an increase in LDL-C level.

show abstract

Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis

Cited by 9 publications

References 36 publications

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Do GST-M, GST-T, and TP53 Gene Polymorphisms Have a Role in Childhood Obesity?

An Assessment of Glutathione-S-Transferase and Lipid Profile in Obese Iraqi Patients

Contact Info

Product

Resources

About