Association of glycaemic variables with trabecular bone score in post‐menopausal women with type 2 diabetes mellitus

Abstract

Aim To determine the relationship between bone microarchitecture, as measured by trabecular bone score, and advanced glycation end-product accumulation, as assessed by skin autofluorescence. Methods This was a cross-sectional study. Participants were 64 post-menopausal women with type 2 diabetes and 175 post-menopausal women without diabetes. Trabecular bone score and skin autofluorescence data were obtained at time of bone density measurement. Results Trabecular bone score and skin autofluorescence were inversely correlated in women with type 2 diabetes (r =-0.34, P = 0.006); no correlation was seen in post-menopausal women without diabetes (r =-0.029, P = 0.707). After adjustment, neither skin autofluorescence nor a diagnosis of diabetes were associated with trabecular bone score, but HbA 1c and waist circumference were independently associated with trabecular bone score. Conclusion Skin autofluorescence did not predict trabecular bone score. In contrast, glycaemia, as reflected by HbA 1c , and visceral adiposity, as reflected by waist circumference, were independently associated with trabecular bone score.

Evaluation of Quality and Bone Microstructure Alterations in Patients with Type 2 Diabetes: A Narrative Review

“…Accordingly, visceral fat reduction may increase TBS values [70]. Furthermore, higher glycated hemoglobin levels and a longer disease duration in patients with T2DM are related to lower TBS values, although the interference of abdominal soft tissue thickness should be considered when interpreting these findings [68,[71][72][73]. Moreover, diabetic microvascular disease may be linked to lower TBS [74].…”

Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case–control studies

“…Finally, 33 case–control studies were included in this study. [ 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 ] Figure 1 shows the PRISMA flowchart for this systematic review and meta-analysis. The included studies were published between 2006 and 2022 years.…”

Use of noninvasive imaging to identify causes of skeletal fragility in adults with diabetes: a review

“… 82–86 A few studies have further reported a negative association between TBS and HbA1c. 71 , 83 , 87 , 88 However, these studies are difficult to interpret, as TBS is negatively associated with waist circumference, 77 , 88 abdominal soft tissue thickness, 80 , 89 and visceral fat mass, 90 suggesting TBS might be reflecting body composition in those with T2D, rather than deficits in bone structure. Accordingly, additional studies are needed to delineate the extent to which increased abdominal fat contributes to lower TBS values among individuals with T2D.…”