Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study

Rospleszcz, Susanne; Schafnitzel, Anina; Köenig, Wolfgang; Lorbeer, Roberto; Auweter, Sigrid; Huth, Cornelia; Rathmann, Wolfgang; Heier, Margit; Linkohr, Birgit; Meisinger, Christa; Hetterich, Holger; Bamberg, Fabian; Peters, Annette

doi:10.1186/s12872-018-0900-7

Cited by 20 publications

(18 citation statements)

References 43 publications

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“…Long-term studies have unequivocally demonstrated the development of left ventricular hypertrophy in metabolic syndrome; 43 however, even prolonged pre-diabetes provides a constellation of physiological derangements that favor left ventricular remodeling in rats 44 , 45 and humans. 46 In fact, fructose alone, albeit at a higher concentration (60%), causes cardiac hypertrophy in mice after 10 weeks. 47 Moreover, direct fructation of structural proteins 29 or alterations in sympathetic cardiac innvervation 48 have been associated with diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Ingestion of fructose plus high salt even, in the short term, in the present study results in mildly elevated non-fasting blood glucose and a depressed glucose:insulin ratio consistent with insulin resistance similar to human pre-diabetes. Long-term studies have unequivocally demonstrated the development of left ventricular hypertrophy in metabolic syndrome; 43 however, even prolonged pre-diabetes provides a constellation of physiological derangements that favor left ventricular remodeling in rats 44,45 and humans. 46 In fact, fructose alone, albeit at a higher concentration (60%), causes cardiac hypertrophy in mice after 10 weeks.…”

Section: Left Ventricular Diastolic Dysfunctionmentioning

confidence: 99%

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<p>Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet</p>

Komnenov¹,

Levanovich²,

Perecki³

et al. 2020

IBPC

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Introduction: High fructose and salt consumption continues to be prevalent in western society. Existing studies show that a rat model reflecting a diet of fructose and salt consumed by the upper 20th percentile of the human population results in salt-sensitive hypertension mitigated by treatment with an antioxidant. We hypothesized that dietary fructose, rather than glucose, combined with high salt leads to aortic stiffening and decreased renal artery compliance. We also expect that daily supplementation with the antioxidant, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (+T; Tempol), will ameliorate the increase in mean arterial pressure (MAP) and vascular changes. Methods: Male Sprague Dawley rats were studied with either 20% fructose or 20% glucose in the drinking water and normal salt (0.4%) or high salt (4%) in the chow resulting in four dietary groups: fructose normal Fru+NS or high salt (Fru+HS) or glucose with normal (Glu +NS) or high salt (Glu+HS). Tempol (+T) was added to the drinking water in half of the rats in each group for 3 weeks. Results: MAP was significantly elevated and the glucose:insulin ratio was depressed in the Fru+HS. Both parameters were normalized in Fru+HS+T. Plasma renin activity (PRA) and kidney tissue angiotensin II (Ang II) were not suppressed in the high salt groups. Pulse wave velocity (PWV), radial ascending strain, and distensibility coefficient of the ascending aorta were significantly decreased in Fru+HS rats and improved in the Fru+HS+T rats. No differences occurred in left ventricular systolic function, but the ratio of early (E) to late (A) transmitral filling velocities was decreased and renal resistive index (RRI) was higher in Fru+HS rats; antioxidant treatment did not change these indices. Discussion: Thus, short-term consumption of high fructose plus high salt diet by rats results in modest hypertension, insulin resistance, diminished aortic and renal artery compliance, and left ventricular diastolic dysfunction. Antioxidant treatment ameliorates the blood pressure, insulin resistance and aortic stiffness, but not renal artery stiffness and left ventricular diastolic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Section: Left Ventricular Diastolic Dysfunctionmentioning

confidence: 99%

<p>Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet</p>

Komnenov¹,

Levanovich²,

Perecki³

et al. 2020

IBPC

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“…Biochemical parameters were assessed in both KORA studies, KORA F4 and KORA FF4, using standard methods described previously. [ 8,24 ]…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Riedl

Hillesheim

Wawro

et al. 2020

Molecular Nutrition Food Res

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Scope: Previous work identified three metabolically homogeneous subgroups of individuals ("metabotypes") using k-means cluster analysis based on fasting serum levels of triacylglycerol, total cholesterol, HDL cholesterol, and glucose. The aim is to reproduce these findings and describe metabotype groups by dietary habits and by incident disease occurrence. Methods and results: 1744 participants from the KORA F4 study and 2221 participants from the KORA FF4 study are assigned to the three metabotype clusters previously identified by minimizing the Euclidean distances. In both KORA studies, the assignment of participants results in three metabolically distinct clusters, with cluster 3 representing the group of participants with the most unfavorable metabolic characteristics. Individuals of cluster 3 are further characterized by the highest incident disease occurrence during follow-up; they also reveal the most unfavorable diet with significantly lowest intakes of vegetables, dairy products, and fibers, and highest intakes of total, red, and processed meat. Conclusion: The three metabotypes originally identified in an Irish population are successfully reproduced. In addition to this validation approach, the observed differences in disease incidence across metabotypes represent an important new finding that strongly supports the metabotyping approach as a tool for risk stratification.

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“…In SHIP-TREND-0, cardiac MR imaging was performed on a 1.5 Tesla MR system (Magnetom Avanto; Siemens Medical Systems, Erlangen, Germany) [11, 14] and in KORA FF4, on a 3 Tesla MR system (Magnetom Skyra; Siemens Medical Systems, Erlangen, Germany) [15, 16]. In both studies imaging of cardiac function and morphology was performed using cine steady-state free precession (cine-SSFP) sequences.…”

Section: Methodsmentioning

confidence: 99%

Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart

Markus

Rospleszcz

Ittermann

et al. 2019

Cardiovasc Diabetol

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BackgroundMortality attributable to heart failure remains high. The prevalence of heart failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 million adults in the United States have diagnosed diabetes mellitus and around 80.8 million have impaired fasting glucose. We investigated the associations of fasting glucose (FG) and fasting insulin (FI), the homeostasis model assessment-insulin resistance index (HOMA-IR) and 2-h postload glucose (2HG) and insulin (2HI) with parameters of left ventricular geometry and function and arterial stiffness determined by magnetic resonance imaging in individuals without diagnosed type 2 diabetes.MethodsCross-sectional analyses of 1001 individuals (453 women, 45.3%), aged 21 to 80 years, from two independent population-based studies, the Study of Health in Pomerania (SHIP-TREND-0) and KORA FF4 Study. FG, FI, HOMA-IR, 2HG and 2HI, as well as glucose tolerance categories, were analyzed for associations with heart and arterial parameters using multivariable-adjusted linear regression models.ResultsIn total, 390 individuals (39%) had prediabetes (isolated impaired fasting glucose, isolated glucose tolerance or both), and 49 (4.9%) were found to have unknown type 2 diabetes. In the multivariable-adjusted analysis, positive linear associations of FG, FI, HOMA-IR, 2HG and 2HI with arterial stiffness index and left ventricular wall-thickness and concentricity and inverse linear associations with left ventricular end-diastolic volume were observed. A 1 mmol/l higher FG was associated with a 1.18 ml/m2.7 (1.80 to 0.57; p < 0.001) lower left ventricular end-diastolic volume index, a 0.042 mm/m2.7 (0.014 to 0.070) higher left ventricular wall-thickness index, a 0.12 mmHg m2.7/ml (0.06 to 0.17; p < 0.001) greater arterial stiffness index and a 0.037 g/ml (0.018 to 0.056; p < 0.001) higher left ventricular concentricity.ConclusionsOur findings suggest that higher glucose levels in the prediabetic range and insulin resistance might lead to higher arterial stiffness and concentric remodeling of the heart.

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Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: a cross-sectional study

Cited by 20 publications

References 43 publications

<p>Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet</p>

<p>Aortic Stiffness and Diastolic Dysfunction in Sprague Dawley Rats Consuming Short-Term Fructose Plus High Salt Diet</p>

Evaluation of the Metabotype Concept Identified in an Irish Population in the German KORA Cohort Study

Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart

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