Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children

Gao, Yu Tang; Yu, Yongfu; Xiao, Jingyuan; Luo, Jiajun; Zhang, Yawei; Tian, Ying; Zhang, Jun; Olsen, Jørn; Li, Jiong; Liew, Zeyan

doi:10.1001/jamanetworkopen.2020.2868

Cited by 30 publications

(18 citation statements)

References 50 publications

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“…Advanced paternal age has been reported to increase the risk for adverse pregnancy and neonatal outcomes such as low birth weight and preterm birth (7). It also may exert a long-term negative impact on the child into adulthood including metabolic risks (22) and psychological disease (11,12). Preliminary evidence also suggests aging fathers may enhance the mortality (9) and shorten the life expectancy of their child (23).…”

Section: Interpretationsmentioning

confidence: 99%

“…There is preliminary evidence to suggest that advanced paternal age may increase the occurrence of adverse pregnancy outcomes such as miscarriage (5), stillbirth (6) or preterm birth (7). The adverse offspring outcomes include higher rates of congenital malformations (8), malignancies (9), early onset schizophrenia (10), autism (11) and other psychiatry or academic morbidities (12).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

et al. 2021

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PurposeWhile it is well documented that maternal adverse exposures contribute to a series defects on offspring health according to the Developmental Origins of Health and Disease (DOHaD) theory, paternal evidence is still insufficient. Advanced paternal age is associated with multiple metabolism and psychiatric disorders. Birth weight is the most direct marker to evaluate fetal growth. Therefore, we designed this study to explore the association between paternal age and birth weight among infants born at term and preterm (<37 weeks gestation).MethodsA large retrospective study was conducted using population-based hospital data from January 2015 to December 2019 that included 69,964 cases of singleton infant births with complete paternal age data. The primary outcome was infant birth weight stratified by sex and gestational age including small for gestational age (SGA, 10th percentile) and large for gestational age (LGA, 90th percentile). Birth weight percentiles by gestational age were based on those published in the INTERGROWTH-21st neonatal weight-for gestational-age standard. Logistic regression analysis and linear regression model were used to estimate the association between paternal age and infant birth weight.ResultsAdvanced paternal age was associated with a higher risk for a preterm birth [35–44 years: adjusted odds ratio (OR) = 1.13, 95%CI (1.03 to 1.24); >44 years: OR = 1.36, 95%CI (1.09 to 1.70)]. Paternal age exerted an opposite effect on birth weight with an increased risk of SGA among preterm infants (35–44years: OR = 1.85, 95%CI (1.18 to 2.89) and a decreased risk among term infant (35–44years: OR = 0.81, 95%CI (0.68 to 0.98); >44 years: OR = 0.50, 95%CI (0.26 to 0.94). U-shaped associations were found in that LGA risk among term infants was higher in both younger (<25 years) (OR = 1.32; 95%CI, 1.07 to 1.62) and older (35–44 years) (OR = 1.07; 95% CI, 1.01 to 1.14) fathers in comparison to those who were 25 to 34 years old at the time of delivery.ConclusionsOur study found advanced paternal age increased the risk of SGA among preterm infants and for LGA among term infants. These findings likely reflect a pathophysiology etiology and have important preconception care implications and suggest the need for antenatal monitoring.

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Section: Interpretationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

et al. 2021

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“…However, environmental risk factors have been the focus of considerable attention in recent years (Schmidt et al, 2019;Surén et al, 2013). The hypothesis that the etiology of ASD is jointly mediated by genetic predispositions and environmental risk factors (Chaste & Leboyer, 2012;Gao et al, 2020;Ijomone et al, 2020;Kim et al, 2019;Lyall et al, 2017;Saxena et al, 2020) has been widely accepted. Environmental factors may trigger predisposing hereditary high-risk gene modifications during fetal development (Oldenburg et al, 2020;Saxena et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression

Xian

Zou

Sun

et al. 2021

J Autism Dev Disord

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We systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD.

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“…It has also been demonstrated that advanced paternal age (the age of over 45 years in men) predisposes to a more frequent occurrence of autism and schizophrenia in a child [6][7][8][9][10][11].…”

Section: Infertility -Prognostic Factorsmentioning

confidence: 99%

“…Wykazano, że takie szkodliwe mutacje mają swoje repozytorium w starzejącej się męskiej linii zarodkowej [5]. Stwierdzono także, że bardziej zaawansowany wiek ojcowski (> 45. roku życia mężczyzny) predysponuje do częstszego występowania autyzmu i schizofrenii u dziecka [6][7][8][9][10][11].…”

Section: Wiek Mężczyzny (Przyszłego Ojca)unclassified

Recommendations on the diagnosis of male infertility — genetic testing [Rekomendacje dotyczące diagnostyki genetycznej w niepłodności męskiej]

Jankowska¹,

Kutkowska-Kaźmierczak²,

Zgliczyński³

et al. 2020

Endokrynologia Polska

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Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children

Cited by 30 publications

References 50 publications

Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

Prenatal Folic Acid Supplements and Offspring’s Autism Spectrum Disorder: A Meta-analysis and Meta-regression

Recommendations on the diagnosis of male infertility — genetic testing [Rekomendacje dotyczące diagnostyki genetycznej w niepłodności męskiej]

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