Association of GST gene polymorphism and noise-induced hearing loss<em>Running title: GST gene polymorphism and NIHL</em>

Abstract

BackgroundIt has been proposed that Noise-induced hearing loss is a complex disease that is combination of environmental and genetic factors. There are inconsistent results concerning the association between variation in glutathione S-transferase (GST) genetic polymorphisms (GSTT1 rs1049055 and GSTM1 rs10712361) and susceptibility to Noise-induced hearing loss.ObjectiveThis study was designed to assess the association between GST gene polymorphism and Noise-induced hearing loss among noise-exposed workers. Methods: In a case-control study, male workers from tile and ceramic factories were selected randomly. Subjects were classified into two groups according to the result of audiometry: 73 subjects showed Noise-induced hearing loss which was considered in the case group and 87 subjects without hearing loss was enrolled in the control group. The GSTT1 and GSTM1 polymorphism of both groups were assessed by multiplex polymerase chain reaction.ResultsNull GSTT1 and GSTM1 genotypes were more frequent in case group but no significant statistical difference was seen in case and control groups. No significant link between GSTT1 and GSTM1 genotypes was found.ConclusionThis study suggests that the genetic variability of GSTT1 and GSTM1 has no effect on susceptibility to noise induced hearing loss.

Association of STAT3 Gene Polymorphism With Noise-induced Hearing Loss(NIHL) in the Chinese Population

“…Also, NIHL has been a critical and leading occupational disease, just following age-related hearing loss (ARHL) worldwide [3]. A research report released by the World Health Organization estimates that nearly 500 million noise-exposed workers worldwide are at high risk of hearing loss [5,6] .…”

Study Highlights Impact of Smoking on Hearing Loss Among Workers Exposed to Noise

“…4 Statistics of Bureau of Labor reveal that NIHL is now recognized as the most commonly recorded occupational disease in manufacturing plants 5 that increases hearing loss disabilities in more than 500 million laborers worldwide. 6 They also reported NIHL is among the nine recorded diseases. 5 No statistics have been done on NIHL in Iran; however, this growing health issue is probably more widespread than developed countries.…”

Однонуклеотидные Полиморфизмы Генов (SNP) Как Маркеры Повышенного Риска Развития Нарушений Здоровья, Связанных С Воздействием Производственного Шума (Обзор)

“…Например, данные о влиянии полиморфизма rs34287852 гена KCNQ4 на развитие ПНСТ в польской и шведской популяциях противоречивые: повышенному риску в польской популяции соответствует комбинация GG, а в шведской -TT[21].Обнаружены также полиморфизмы, которые снижают вероятность развития профессиональной потери слуха. Данное свойство показано для делеций генов GSTM1 и GSTT1 для китайской популяции[23] и в многопопуляционном исследовании[24], но не подтверждается для иранской популяции[25]. Также защитными считаются полиморфизмы в генах NRF2[26] и CARD8[27].В таблице 1 представлены сводные данные о SNP, влияющих на риск нейросенсорной тугоухости в условиях воздействия производственного шума.Таблица 1/…”