Association of Guillain-Barre Syndrome With COVID-19: A Case Report and Literature Review

Abstract

There is growing evidence of neurological involvement in patients with coronavirus disease 19 (COVID-19), suggesting that Guillain-Barre syndrome (GBS) can also occur with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a neurological complication. Herein, we describe a unique case of a 45-year-old male who manifested with sudden onset progressive symmetric ascending paralysis leading to quadriplegia one week after developing fever, cough, and dyspnea. On examination, he had areflexia in lower limbs and hyporeflexia in upper limbs. Hypoesthesia to fine touch and vibration distal to calf was noted. His reverse transcriptase-polymerase chain reaction (RT-PCR) was positive for COVID-19, and his cerebrospinal fluid (CSF) analysis revealed albumin-cytologic dissociation. The diagnosis of GBS was made based on clinical presentation and neurophysiological studies due to COVID-19. He was commenced on intravenous immunoglobulin, and improvement in his condition was observed. He was discharged to a rehabilitation center for regular physical therapy.

A Flare of Systemic Lupus Erythematosus Disease After COVID-19 Infection: A Case of Lupus Cerebritis

“…COVID-19 generally presents with signs and symptoms of the respiratory system, including flu-like illness complicated by acute respiratory distress syndrome (ARDS) and lung failure [2]. Other manifestations and complications include severe metabolic syndrome, acute kidney injury, neurological syndromes, cardiovascular and thromboembolic events such as encephalopathy, seizures, and stroke [3][4][5][6][7]. A possible association between COVID-19 and autoimmune disease has also been reported in many case reports [8].…”

Vaccine Development Throughout History

“…From asymptomatic infection to respiratory failure, multi-organ dysfunction, and death, the COVID-19 has a wide spectrum of clinical presentations [33]. COVID-19 has been linked to harmful effects on other body systems in addition to the respiratory system [34][35][36][37][38]. Although SARS-CoV-2 has a lower mortality rate in comparison with SARS-CoV and MERS-CoV, the transmissibility and spread are much higher than SARS-CoV-1 and MERS.…”

Coronavirus Disease 2019 Pneumonia and Acute Pancreatitis in a Young Girl

“…COVID-19 has a typical manifestation of the respiratory system and generally presents with fever, cough, dyspnea, and fatigue. COVID-19 has also demonstrated signs and symptoms in the gastrointestinal (GI) system, cardiovascular system, and neurological system [4][5][6][7]. Nausea, vomiting, abdominal pain, and diarrhea have also been reported as an initial manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [8].…”