Association of Gut Microbiome with Early Brain Injury After Subarachnoid Hemorrhage: an Experimental Study

Kawabata, Shuhei; Takagaki, Masatoshi; Nakamura, Hajime; Nishida, Tomomi; Terada, Eisaku; Kadono, Yoshinori; Izutsu, Nobuyuki; Takenaka, Toshifumi; Matsui, Yuichi; Yamada, Shuhei; Fukuda, Tatsumaru; Nakagawa, Ryota; Kishima, Haruhiko

doi:10.1007/s12975-022-01112-6

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…The glucose to potassium ratio and NLR, which is related to the acute inflammatory response and percentage of lymphocytes, have also frequently been reported to be correlated with aSAH and other acute brain injury-related diseases, in recent years. 17,20,[24][25][26]28,[39][40][41][42] Further studies should focus on laboratory findings, including these indices, in patients with WFNS grade V aSAH.…”

Section: Discussionmentioning

confidence: 99%

“…9,[11][12][13][14] The clinical severity of aSAH at admission has been reported to reflect the acute inflammatory response, including early brain injury (EBI). [15][16][17] In patients with WFNS grade V, the impact of EBI on their outcomes may be heterogeneous 16,18 and should be considered when developing outcome prediction models.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have reported that specific blood test findings at admission correlate with EBI or outcomes after aSAH. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] However, no previous study has successfully predicted the outcome in patients with WFNS grade V aSAH, based on the routine examinations and findings obtained at admission, including these laboratory findings.…”

Section: Introductionmentioning

confidence: 99%

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Outcome Prediction in Aneurysmal Subarachnoid Hemorrhage with World Federation of Neurological Societies grade V(OPAS-V)

Yamada

Nishida

Takenaka

et al. 2023

Preprint

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Background<break>Aneurysmal subarachnoid hemorrhage (aSAH) with World Federation of Neurological Societies (WFNS) grade V has a high mortality rate and poor prognosis. Some patients with WFNS grade V aSAH have had good outcomes after aggressive treatment; however, outcome predictions based on routine examinations and findings obtained at admission are yet to be reported. This study aimed to develop a decision tree model for predicting outcomes of patients with WFNS grade V aSAH to aid decision-making for treatment strategy.<break><break>Methods<break>A multicenter study with retrospective and prospective data collected from 201 (derivation cohort) and 12 (validation cohort) patients with WFNS grade V aSAH, respectively, was conducted. Clinical outcomes were divided into good (Modified Rankin Scale [mRS] score at the time of discharge: 02) and poor (mRS score: 36) outcomes. A decision tree model was developed for the derivation cohort using the classification and regression tree method with clinical data including laboratory findings; it was named OPAS-V (Outcome Prediction in Aneurysmal Subarachnoid hemorrhage with WFNS grade V). The performance of the model was evaluated by area under the curve (AUC) and overall accuracy in both cohorts.<break><break>Results<break>OPAS-V comprised 3 metrics; the percentage of lymphocytes (<49.9% or not), age (>50 yrs or not), and glucose to potassium ratio (3.2 or not). The model achieved an AUC of 0.828 (95% confidence interval: 0.7120.944) and overall accuracy of 0.930. Moreover, the model performed well in the validation cohort with an AUC of 0.700 (95% confidence interval: 0.2001) and overall accuracy of 0.833.<break><break>Conclusions<break>This study developed the first decision tree model for predicting outcomes of patients with WFNS grade V aSAH, based on simple findings obtained at admission. This may aid clinicians in determining treatment strategies for severe conditions such as WFNS grade V aSAH.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Outcome Prediction in Aneurysmal Subarachnoid Hemorrhage with World Federation of Neurological Societies grade V(OPAS-V)

Yamada

Nishida

Takenaka

et al. 2023

Preprint

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“…Other less-studied pathways that induce NETs include those involving signal inhibitory receptor 1 (SIRL1) [51] and extracellular cold-inducible RNA-binding protein (eCIRP) through PD4 [52]. In addition, the formation of mitochondria-dependent vital NETs by silent information regulator 1 (SIRT1) that has been reported in both tumour-associated aged neutrophils (Naged, CXCR4+ CD62L low) in breast cancer lung metastasis [53] and non-tumour pathologies [54] has not been studied in preeclampsia.…”

Section: Netsmentioning

confidence: 99%

Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia

Hernández González,

Pérez-Campos Mayoral,

Hernández-Huerta

et al. 2024

Pharmaceuticals

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Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as crucial players in the induction of endothelial cell death and the modulation of endothelial cell responses under both physiological and pathological conditions. The hallmark of preeclampsia is endothelial dysfunction induced by systemic inflammation, in which neutrophils, particularly through the formation of neutrophil extracellular traps (NETs), play a pivotal role in the development and perpetuation of endothelial dysfunction and the hypertensive state. Considering the potential of numerous pharmaceutical agents to attenuate NET formation (NETosis) in preeclampsia, a comprehensive assessment of the extensively studied candidates becomes imperative. This review aims to identify mechanisms associated with the induction and negative regulation of NETs in the context of preeclampsia. We discuss potential drugs to modulate NETosis, such as NF-κβ inhibitors, vitamin D, and aspirin, and their association with mutagenicity and genotoxicity. Strong evidence supports the notion that molecules involved in the activation of NETs could serve as promising targets for the treatment of preeclampsia.

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Phenotypes and functions of “aged” neutrophils in cardiovascular diseases

Ling,

2024

Biomedicine & Pharmacotherapy

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Association of Gut Microbiome with Early Brain Injury After Subarachnoid Hemorrhage: an Experimental Study

Cited by 5 publications

References 33 publications

Outcome Prediction in Aneurysmal Subarachnoid Hemorrhage with World Federation of Neurological Societies grade V(OPAS-V)

Outcome Prediction in Aneurysmal Subarachnoid Hemorrhage with World Federation of Neurological Societies grade V(OPAS-V)

Targeting Neutrophil Extracellular Trap Formation: Exploring Promising Pharmacological Strategies for the Treatment of Preeclampsia

Phenotypes and functions of “aged” neutrophils in cardiovascular diseases

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