Association of gut microbiota with COVID‐19 susceptibility and severity: A two‐sample Mendelian randomization study

Shang, Weifeng; Zhang, Sheng; Qian, Hang; Pan, Xiaojun; Huang, Sisi; Wen, Zhenliang; Liu, Jiao; Chen, Dechang

doi:10.1002/jmv.28734

Cited by 9 publications

(8 citation statements)

References 50 publications

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“…Intestinal barrier impairment, dysbiosis of gut microbiota, and perturbation of metabolites are prevalent occurrences among individuals with COVID‐19. Extensive research has consistently shown the association between microbiota composition and the morbidity, exacerbation, and mortality rates seen in COVID‐19 patients 51–55 . The gut microbiota facilitates the assessment of sickness severity in individuals with COVID‐19 56 .…”

Section: Discussionmentioning

confidence: 99%

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Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID‐19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID‐19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID‐19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID‐19 and CP. A direct causal relationship between genetically predicted COVID‐19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID‐19 as a definitive cause of pancreatitis.

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Section: Discussionmentioning

confidence: 99%

“…patients. [51][52][53][54][55] The gut microbiota facilitates the assessment of sickness severity in individuals with COVID-19. 56 From a mechanical standpoint, it is observed that COVID-19 disrupts the composition of gut microbiota and metabolites.…”

Section: Potential Confounding Factors and Mechanismsmentioning

confidence: 99%

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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“…We set the following steps to screen the best IVs to ensure the robustness of our study; first, screening of significantly relevant SNPs from gut microbiome GWAS data as IVs. However there is a problem that is prevalent in MR studies of the gut microbiota 19 , 23 . If the number of SNPs obtained by using the genome-wide statistical significance threshold ( p <5×10-8) is few, it may lead to biased results.…”

Section: Methodsmentioning

confidence: 99%

“… 26 Third, removal of palindromic SNPs with A/T or G/C structures from SNPs obtained in the second step. 19 , 26 Finally, we calculated the F statistic to detect the strength of the correlation between the SNPs obtained in the third step and the exposure, removing SNPs with weak instrumental bias ( F values <10). 27 …”

Section: Methodsmentioning

confidence: 99%

Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis

Gao,

Liu,

et al. 2024

CCID

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Background Traditional observational studies have found a possible risk association of the gut microbiota for psoriasis. Meanwhile, psoriasis may also affect the changes in the gut microbiota. However, the available evidence does not demonstrate a reciprocal relationship between the gut microbiota and psoriasis. This limits our understanding on the role of the gut microbiota in the mechanisms of psoriasis. Methods To address this question we used Mendelian randomization, a novel epidemiological approach, and acquired the largest current gut microbiota GWAS data from the MiBioGen consortium as well as psoriasis GWAS data from the FinnGen consortium, and performed two-sample bidirectional MR analyses using a multiple MR analysis approach. Finally, the robustness of the results was assessed by sensitivity analysis. Results Our results indicate that five bacterial genera are causally related to psoriasis and psoriasis is causally related to four bacterial genera. Conclusion These results suggest a bidirectional causal influence of psoriasis on the gut microbiota. Our results somewhat challenge the causal inferences of previous observational studies. We found that the specific bacterial genera with a risk effect on psoriasis were different from those found to characterize psoriasis in previous observational studies, and that these psoriasis-characterizing genera were inversely associated with psoriasis.

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“…These findings suggest that the gut microbiota may have a causal relationship with the severity of COVID‐19, thus providing new evidence and ideas for the study of the pathogenesis of SARS‐CoV‐2 mediated by gut microbiota. 107 , 108 …”

Section: Dynamic Changes Of Microbiota In Covid‐19mentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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Association of gut microbiota with COVID‐19 susceptibility and severity: A two‐sample Mendelian randomization study

Cited by 9 publications

References 50 publications

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

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