Association of H. pylori infection with chronic kidney disease among Chinese adults

Kong, Xianglei; Xu, Dayu; Li, Feng; Ma, Xiaojing; Hong, Soon-Kwang; Xu, Dongmei

doi:10.1007/s11255-016-1498-2

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…In contrast to our study, there was a study conducted in china by Kong et al [26] included 22,044 adults Chinese individuals and found that the prevalence of proteinuria and the overall CKD were not significantly different between these two studied groups (1.7 vs. 1.6%, P = 0.65 and 3.0 vs. 2.7%, P = 0.2). After adjusted for age, sex hypertension, diabetes, body mass index, uric acid, smoking drinking, total cholesterol, triglycerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol the odds of decreased eGFR and proteinuria were not significantly different between the H. Pylori positive and negative subjects.…”

Section: Discussioncontrasting

confidence: 99%

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

Balat¹,

Zanaty²,

Elantouny³

et al. 2019

Zagazig University Medical Journal

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Background: The incidence Helicobacter pylori infection and its possible relationship to different diseases are a focus of attention nowadays. Therefore, the aim of this study was to examine the association between proteinuria and active Helicobacter pylori infection in middle age nondiabetic patients. Material and Methods: A Case-control study was conducted on118 subjects and included 59 patients who suffered from H. pylori infection from October 2017 to April 2018. 59 patients were negative H. pylori infection included and served as a control group. Demographic and clinical data were collected. Results: The infected H. Pylori group showed a significant higher ACR compared to the control group. In addition, infected H. Pylori group showed a significant lower hemoglobin and albumin compared to the control group. Conclusion: Patients having H. Pylori infection show a significant elevation in the urinary albumin/creatinine ratio and a significant anemia suggesting a role of H. Pylori infection in the pathogenesis of proteinuria and anemia.

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Section: Discussioncontrasting

confidence: 99%

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

Balat¹,

Zanaty²,

Elantouny³

et al. 2019

Zagazig University Medical Journal

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“…The reasons for study exclusion during the final review were as follows: narrative review article (n=7), meta-analysis or systematic review (n=5), letters, comment, editorial or reply to questions (n=15), abstract-only article (n=4), case study (n=5), duplicated data (n=1), and incomplete data (n=134). Forty-eight studies22–69 were included in the systematic review; however, study by Kong et al 40. showed no crude rate of H. pylori infection, therefore, this was excluded in the final meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The duration of dialysis in the enrolled population ranged from at least 6 months to 8.4±0.3 years (mean±standard deviation). Most studies presented a crude rate of H. pylori infection in patients with CKD versus a control group, and two studies37,40 presented adjusted ORs, which were adjusted for age, sex, peptic ulcer history, steroid or medication use, diabetes, hypertension, chronic heart failure, coronary artery disease, and liver cirrhosis in Chang and Hu37 and for sex, age, hypertension, diabetes, body mass index, uric acid, smoking, drinking, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in Kong et al 40. The clinical characteristics of the included studies are shown in Table 2 (study by Kong et al .…”

Section: Resultsmentioning

confidence: 99%

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Helicobacter pyloriInfection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

et al. 2019

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Background/AimsInsufficient systematic reviews were conducted in the previous meta-analyses about the prevalence of Helicobacter pylori infection in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prevalence of H. pylori infection in patients with CKD.MethodsA systematic review of studies that evaluated the prevalence of H. pylori infection in patients with CKD compared to a control group was performed. Only studies with adult patients were included, and studies with renal transplant recipients or diabetic nephropathy patients were excluded. Random-effects model meta-analyses with sensitivity analyses and subgroup analyses were conducted to confirm the robustness of the main result. A meta-regression analysis was conducted to explore the influence of potential heterogeneity on the outcomes. The methodological quality of the included publications was evaluated using the Risk of Bias Assessment tool for Nonrandomized Studies. Publication bias was also assessed.ResultsIn total, 47 studies were identified and analyzed. The total prevalence of H. pylori infection was 48.2% (1,968/4,084) in patients with CKD and 59.3% (4,097/6,908) in the control group. Pooled analysis showed a significantly lower prevalence of H. pylori infection in patients with CKD (vs control group: odds ratio, 0.64; 95% confidence interval, 0.52 to 0.79). Sensitivity analyses revealed consistent results, and meta-regression analysis showed no significant confounders. No publication bias was detected.ConclusionsThe results of this study suggest a lower prevalence of H. pylori infection in patients with CKD.

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“…Although emerging evidence showed the association of H. pylori infection and chronic kidney disease [22,23], several studies reported no association [24,25]. To date, the association of H. pylori infection with chronic kidney disease has been controversial.…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer

Pan

Zhang

Wang³

et al. 2019

Renal Failure

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Background: Helicobacter pylori (H. pylori) is relevant to several renal diseases. Our previous research indicates that cytotoxin-associated gene A (CagA) of H. pylori increases secretion of serum immunoglobulin A1 (IgA1) and induces the underglycosylation of IgA1, one of the key factors causing IgA nephropathy. Here, we aimed to study the correlation between H. pylori infection and kidney damage in patients with peptic ulcer, and evaluate the effect of H. pylori eradication on kidney damage.Methods: 14C-urea breath test and rapid urease tests were applied to H. pylori infection detection. Random urine samples are subjected to the albumin–creatinine ratio (ACR) examination. The correlation between ACR and H. pylori infection was analyzed in patients with peptic ulcer and healthy controls. The levels of IgA and underglycosylated IgA1 in serum are also detected by enzyme-linked immunosorbent assay (ELISA) and Helix aspersa lectin (HAA) binding assay.Results: (1) H. pylori infection rate in patients with peptic ulcer (88.14%) is significantly higher than that in healthy controls (42.68%). (2) There is a positive correlation between H. pylori infection and ACR abnormal in patients with peptic ulcer (p = .025), while showing a negative correlation in healthy individuals (p = .571). (3) Urinary ACR was uncorrelated with the severity of H. pylori infection in the 27 abnormal urinary ACR cases of the patients with peptic ulcer. (4) After H. pylori eradication, the ACR rates of H. pylori-positive patients with peptic ulcer were significantly decreased (p<.01).Conclusions: (1) For the H. pylori-positive patients with peptic ulcer, H. pylori infection may be a risk factor resulting in kidney damage. (2) H. pylori eradication probably benefits to kidney damage relief and chronic kidney disease prevention.

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Association of H. pylori infection with chronic kidney disease among Chinese adults

Cited by 10 publications

References 37 publications

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

Helicobacter pyloriInfection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Association between Helicobacter pylori infection and kidney damage in patients with peptic ulcer

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