Association of haematological and biochemical parameters, ultrasonographic and upper GI endoscopic findings with sero prevalence of HBV and HCV among chronic liver disease patients in a tertiary care hospital

Abstract

Background: Now-a-days chronic liver disease is one of the major health problems in the world. In developing countries, chronic liver disease due to hepatitis virus (like hepatitis B and hepatitis C virus) is increasing day by day. It is rapidly emerging as a major health problem. So, the present study was conducted to document the hepatitis B and hepatitis C virus in patient with chronic liver disease by an easy and simple marker like HBsAg, Anti HBc (total) and Anti HCV in a tertiary hospital. Methods: Serum samples were collected from 100 selected cases who were diagnosed as a case of chronic liver disease in medicine and gastroenterology department of DMCH. Study period was from April 01, 2016 to September 30, 2018. For detection of HBsAg, Anti HBc (total) and Anti-HCV, Immunochromatographic test (ICT) was done in every case. Results: Out of 100 cases, HBsAg seropositive with negative Anti-HCV was found in 64% cases, Anti HCV positive with negative HBsAg was found in 16% cases, both HBsAg and Anti HCV positive was found in 4% cases, both HBsAg and Anti-HCV negative was found in 16% cases. Among these cases, 74% were male and 26% were female. Here male: female was 3:1 and among them, 75% male was seropositive for either HBsAg or Anti-HCV. Conclusion: The high frequency of seropositivity in patients with chronic liver disease with male predominance is found in tertiary care settings. The number of Anti-HCV seropositive patient indicates that it is an emerging health problem in our country.

Clinico-Pathological Profile of patients Suffering from Chronic Liver Disease Secondary to Viral Hepatitis

“…Maximum number of patients had developed stigmata of CLD; 79.87% had splenomegaly, 66.23% had spider naevi, 86.36% had ascites and 87.67% had esophageal varices representing the advanced stage of their disease. Gomez et al had also reported that 28% of their patients had hepatomegaly, 86% had splenomegaly, 90% of their study participants had ascites (ranging from mild to huge) and almost all of their patients had varying grades of esophageal varices 13 .…”

“…Laboratory parameters of our study population revealed mean values of bilirubin, alkaline phosphatase, alanine aminotransferase (ALT), albumin and prothrombin time (PT) were 1.43±1.21 mg/dL, 105.33±51.51 U/L, 85.89±89.65 U/L, 3.82±0.65 g/dL, 62.57±22 seconds respectively. Mean bilirubin levels were found to be 2.4mg/dL while mean albumin levels were 24.1gm/L in a study which was conducted in Bangladesh 13 .…”