Association of haemoglobin levels in the first trimester and at 26–30 weeks with fetal and neonatal outcomes: a secondary analysis of the Global Network for Women's and Children's Health's ASPIRIN Trial

Jessani, Saleem; Saleem, Sarah; Hoffman, Matthew; Goudar, Shivaprasad S; Derman, Richard; Moore, Janet; Garcés, Ana; Figueroa, Lester; Krebs, Nancy F.; Okitawutshu, Jean; Tshefu, Antoinette; Bose, Carl; Mwenechanya, Musaku; Chomba, Elwyn; Carlo, Waldemar A.; Das, Prabir Kumar; Patel, Archana; Hibberd, Patricia L.; Esamai, Fabian; Liechty, Edward A.; Bucher, Sherri; Nolen, Tracy L.; Koso‐Thomas, Marion; Miodovnik, Menachem; McClure, Elizabeth M; Goldenberg, Robert L.

doi:10.1111/1471-0528.16676

Cited by 16 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibiotics were given to treat infection and physiotherapy is given to relieve muscle rigidity. (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) The Japanese encephalitis (JE) virus is a flavivirus that is widespread in Asia and is spread via mosquitoes. Less than one case is thought to occur in every million passengers in non-endemic countries.…”

Section: Discussionmentioning

confidence: 99%

Case Report on Nursing Management of Japanese Encephalitis with Convulsion

2022

pnr

View full text Add to dashboard Cite

Background: Japanese encephalitis (JE) is an important viral disease-causing fatal condition in children. Vaccination against JE is a significant preventive measure as the specific drugs are not available for treatment. It shows symptoms including Fever, altered sensorium, and Muscle. Patient presentation: We are presenting a 2-year-old male child who visited the pediatric outpatient unit with the symptoms of muscle rigidity, fever, and seizure, he was admitted to pediatric ward no.-17. He was a known case of Japanese Encephalitis. He was diagnosed to have seizures at the age of 1 year when he was admitted to the hospital due to fever. Till then, he was admitted to a private hospital from time to time because of a critical condition in PICU and was on higher multi anti-epileptics. There are not any abnormalities found in the head-to-toe examination, the child is thin and looks dull and also his muscle looks stiff and neck movements are very slow. He is a weak child. The patient's physical and clinical examination was taken. He was treated with high multi-epileptics and physiotherapy is continued. After treatment, the patient's condition improves. Symptoms such as fever, altered sensorium, and convulsion are minimized and muscle stiffness is improved. Conclusion: It can be transmitted to humans by mosquitoes belonging to the species Culex (mainly Culex tritaeniorhynchus), which breed mostly found in rice paddles. A mosquito carrying Japanese Encephalitis can transmit it by feeding on pigs and wild birds carrying the disease. It cannot be transmitted from person to person. As a result of the dramatic increase in vector populations during rainy seasons, diseases are highly transmitted. There is no cure for the disease, but there are vaccines that can prevent the spread of the disease. By treating the infection, the patient can protect themselves from further damage and will be relieved of severe clinical signs.

show abstract

Section: Discussionmentioning

confidence: 99%

Case Report on Nursing Management of Japanese Encephalitis with Convulsion

2022

pnr

View full text Add to dashboard Cite

show abstract

“…Many studies in India and elsewhere have examined the impact of maternal anemia on perinatal outcomes, such as stillbirth, low birth weight, small for gestational age, and preterm birth [8,9,[33][34][35][36]. Far fewer studies have examined the impact of maternal anemia on maternal outcomes, even by systematic review of LMIC data [6,15].…”

Section: Comparison With the Literaturementioning

confidence: 99%

“…Maternal anemia has well established connections with adverse neonatal outcomes such as low birth weight, small for gestational age and premature delivery [6][7][8][9]. Further, recent evidence from diverse LMIC settings found maternal deaths to be nearly twice as high in individuals with severe anemia [10].…”

Section: Introductionmentioning

confidence: 99%

Anemia and adverse outcomes in pregnancy: subgroup analysis of the CLIP cluster-randomized trial in India

Bone

Bellad

Goudar

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Iron-deficiency anemia is a known risk factor for several adverse perinatal outcomes, but data on its impact on specific maternal morbidities is less robust. Further, information on associations between anemia in early pregnancy and subsequent outcomes are understudied. Methods The study population was derived from the Community Level Interventions for Pre-eclampsia (CLIP) trial in Karnataka State, India (NCT01911494). Included were women who were enrolled in either trial arm, delivered by trial end date, and had a baseline measure of hemoglobin (Hb). Anemia was classified by WHO standards into four groups: none (Hb ≥ 11 g/dL), mild (10.0 g/dL ≤ Hb < 11.0 g/dL), moderate (7.0 g/dL ≤ Hb < 10.0 g/dL) and severe (Hb < 7.0 g/dL). Targeted maximum likelihood estimation was used to estimate confounder-adjusted associations between anemia and a composite (and its components) of adverse maternal outcomes, including pregnancy hypertension. E-values were calculated to assess robustness to unmeasured confounding. Results Of 11,370 women included, 10,066 (88.5%) had anemia, that was mild (3690, 32.5%), moderate (6023, 53.0%), or severe (68, 0.6%). Almost all women (> 99%) reported taking iron supplements during pregnancy. Blood transfusions was more often administered to those with anemia that was mild (risk ratio [RR] 2.16, 95% confidence interval [CI] 1.31–3.56), moderate (RR 2.37, 95% CI 1.56–3.59), and severe (RR 5.70, 95% CI 3.00–10.85). No significant association was evident between anemia severity and haemorrhage (antepartum or postpartum) or sepsis, but there was a U-shaped association between anemia severity and pregnancy hypertension and pre-eclampsia specifically, with the lowest risk seen among those with mild or moderate anemia. Conclusion In Karnataka State, India, current management strategies for mild-moderate anemia in early pregnancy are associated with similar rates of adverse maternal or perinatal outcomes, and a lower risk of pregnancy hypertension and preeclampsia, compared with no anemia in early pregnancy. Future research should focus on risk mitigation for women with severe anemia, and the potential effect of iron supplementation for women with normal Hb in early pregnancy.

show abstract

“…Due to theoretical concern about the impact of using such therapeutic medications during maternity, pregnant women should not be denied potentially beneficial COVID-19 treatments. The medicine's safety for pregnant or nursing females, as well as the foetus, should be investigated by the patient and the professional team as well as the severity of maternal disease should be evaluated during this collaborative decision-making process [10][11][12][13][14][15].…”

Section: Postnatal Managementmentioning

confidence: 99%

Management of Obstetrics and Gynecological Patients with COVID-19

Heda

Sharma

Singam

et al. 2021

JPRI

View full text Add to dashboard Cite

Since December 2019, the Coronavirus illness, commonly known as COVID19, has quickly spread from Wuhan, China. The first COVID-19 patient was identified in Italy on February 20, 2020, and developed respiratory failure, prompting hospitalization to the critical care unit (ICU). For more than a year, the highly contagious and lethal coronavirus illness has been causing havoc on the earth. It has progressed to a pandemic level affecting the lives of millions around the globe. The condition can afflict anybody, and there is currently no definitive treatment. Pregnant women do not appear to be more susceptible to infection than the general population. On the other hand, pregnant women have a different immune system and a stronger overall response to viral infections, which could lead to more severe symptoms in some cases, such as COVID-19. COVID-19 presents a minimal overall risk to expecting moms. On the other hand, pregnancy increases the chance of COVID-19-related severe illness and fatality. On the other hand, pregnant women may be more susceptible to serious, potentially fatal respiratory illnesses. Furthermore, research shows that maternal-fetal transfer occurs via contact with respiratory secretions, excluding transmission in the womb. As a result, the best way to manage breastfeeding is uncertain, and the infant may need to be isolated from the mother for a short time. Finally, because healthcare providers are at a higher risk of infection during birth, further measures must be followed along with a proper management and care plan of both the mother and the health care provider.

show abstract

Association of haemoglobin levels in the first trimester and at 26–30 weeks with fetal and neonatal outcomes: a secondary analysis of the Global Network for Women's and Children's Health's ASPIRIN Trial

Cited by 16 publications

References 27 publications

Case Report on Nursing Management of Japanese Encephalitis with Convulsion

Case Report on Nursing Management of Japanese Encephalitis with Convulsion

Anemia and adverse outcomes in pregnancy: subgroup analysis of the CLIP cluster-randomized trial in India

Management of Obstetrics and Gynecological Patients with COVID-19

Contact Info

Product

Resources

About