Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex

Lee, Sung-Bum; Moon, Ji Eun; Kim, Jong Koo

doi:10.3390/diagnostics12081874

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…Handgrip strength is a prognostic indicator for metabolic syndrome, hypertension and diabetes (28)(29)(30). However, these studies commonly suggested that HGS be a practical tool to evaluate these comorbidities in high-risk groups rather than healthy groups.…”

Section: Discussionmentioning

confidence: 99%

Association of handgrip strength with new-onset CKD in Korean adults according to gender

et al. 2023

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IntroductionHandgrip strength (HGS) is an indicator of many diseases such as pneumonia, cardiovascular disease and cancer. HGS can also predict renal function in chronic kidney disease (CKD) patients, but the value of HGS as a predictor of new-onset CKD is unknown.Methods173,195 subjects were recruited from a nationwide cohort and were followed for 4.1 years. After exclusions, 35,757 participants remained in the final study, and CKD developed in 1063 individuals during the follow-up period. Lifestyle, anthropometric and laboratory data were evaluated in relation to the risk of CKD.ResultsThe participants were subdivided into quartiles according to relative handgrip strength (RGS). Multivariate Cox regression demonstrated that RGS was inversely associated with incident CKD. Compared with the lowest quartile, the hazard ratios (HRs) [95% confidence intervals (CIs)] for incident CKD for the highest quartile (Q4) was 0.55 (0.34–0.88) after adjusting for covariates in men and 0.51 (0.31–0.85) in women. The incidence of CKD decreased as RGS increased. These negative associations were more significant in men than in women. The receiver operating characteristic (ROC) curve showed that baseline RGS had predictive power for new-onset CKD. Area under the curve (AUC) (95% CIs) was 0.739 (0.707–0.770) in men and 0.765 (0.729–0.801) in women.ConclusionThis is the novel study demonstrating that RGS is associated with incident CKD in both men and women. The relationship between RGS and incident CKD is more significant in women than in men. RGS can be used in clinical practice to evaluate renal prognosis. Regular measurement of handgrip strength is essential to CKD detection.

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Section: Discussionmentioning

confidence: 99%

Association of handgrip strength with new-onset CKD in Korean adults according to gender

et al. 2023

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“…Jumlah lemak pada laki-laki 15-20% dari berat badan sedangkan perempuan 20-25% dari berat badan. Jadi peningkatan kadar lemak pada perempuan lebih tinggi dibandingkan lakilaki, sehingga faktor terjadinya diabetes mellitus pada perempuan 3-7 kali lebih tinggi dibandingkan pada laki-laki yaitu 2-3 kali (15) (21). Penurunan kekuatan otot berhubungan dengan peningkatan kadar penanda inflamasi (tumor necrosis factoralpha (TNF-α), interleukin-6 (IL-6), dan Creactive protein (CRP)), yang dapat menginduksi perkembangan diabetes (21).…”

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Aktivitas Fisik Penderita Diabetes Mellitus Terhadap Nilai Handgrip Strength Test

Diani,

Maulana,

Isnarawati

et al. 2022

jdk

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Diabetes melitus merupakan penyakit metabolik yang memiliki kumpulan gejala akibat peningkatan kadar glukosa darah di atas nilai normal karena penurunan kemampuan tubuh untuk bereaksi dengan insulin, gangguan sekresi insulin, atau keduanya. Aktivitas fisik yang kurang dapat memicu pertambahan berat badan sehingga mengalami obesitas yang dapat meningkatkan risiko diabetes melitus. Handgrip strength test merupakan metode untuk memprediksi resiko malnutrisi pada pasien akibat komplikasi penyakit, seperti diabetes melitus. Hal ini disebabkan kondisi hiperglikemia yang mempengaruhi fungsi kontraktil dan kekuatan otot sehingga menurunkan kekuatan genggam otot. Tujuan dalam penelitian ini adalah untuk menganalisis aktivitas fisik penderita diabetes melitus terhadap nilai handgrip strength test. Rancangan penelitian ini adalah deskriptif analitik dengan pendekatan cross sectional. Tehnik pengambilan sampel berupa purposive sampling dengan jumlah responden 40 orang. Hasil yang didapatkan adalah p-value antara nilai handgrip dan aktivitas fisik adalah 0.894 > 0,05, kesimpulan tidak terdapat hubungan aktivitas fisik dan nilai handgrib pasien diabetes melitus Hal ini tergambar pasien diabetes melitus berupaya mengurangi aktivitas beratnya (aktivitas fisik sedang: 42,5%) sehubungan kekuatan ototnya berkurang (nilai handgrip yang kurang: 90,0%).

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“…However, the study participants were limited to obese women with an average age of approximately 70 years, and the number of participants was relatively low (approximately 600) [8]. Lee et al reported an inverse association between RGS and prevalence of diabetes mellitus (DM) in a study targeting a Korean population [9]. The number of participants was approximately 20,000, which gave the study the advantage of being a large-group study.…”

Section: Introductionmentioning

confidence: 99%

“…The number of participants was approximately 20,000, which gave the study the advantage of being a large-group study. However, since it was a cross-sectional study, the relationship between RGS and the incidence of DM could not be determined [9]. Wander et al studied the relationship between HGS and occurrence of diabetes among Japanese-Americans who had not been diagnosed with diabetes in the United States and found an inverse association between HGS and the incidence of diabetes in the leaner group with a low BMI [10].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Handgrip Strength and Incident Diabetes in Korean Adults According to Gender: A Population-Based Prospective Cohort Study

Lee,

Jo,

Moon

et al. 2024

JCM

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(1) Background: Diabetes mellitus (DM) is a well-known disease that causes comorbidities such as chronic kidney disease (CKD) and cardiovascular disease. Therefore, it is necessary to develop diagnostic tools to prevent DM. Handgrip strength, a known diagnostic tool for sarcopenia, is a predictor of several diseases. However, the value of handgrip strength as an indicator of incident DM in Asian populations remains unknown. This study aimed to identify the relationship between handgrip strength and incidence of DM in Korean adults according to sex. (2) Methods: A total of 173,195 participants registered in a nationwide cohort were included in this study. After applying the exclusion criteria, 33,326 participants remained. DM occurred in 1473 individuals during the follow-up period (mean follow-up period, 4.1 years). To reduce the impact of body size, the study population was subdivided into quartiles of relative handgrip strength, defined as absolute handgrip strength divided by body mass index. Multivariate Cox regression analysis revealed that the relative handgrip strength was inversely associated with new-onset DM. (3) Results: Compared with the lowest quartile (Q1), the hazard ratios (HRs) [95% confidence intervals (CIs)] for new-onset DM for the highest quartiles (Q4) was 0.60 (0.43–0.84) in men and 0.72 (0.52–0.99) in women after adjusting for confounding factors. The incidence of DM decreased with the increase in the relative handgrip strength. These inverse relationships were statistically more significant in men than in women. (4) Conclusions: This novel study revealed that relative handgrip strength is related to incident DM in both men and women. Relative handgrip strength can be used as a practical tool to prevent DM. Regular measurement of handgrip strength can be used to detect DM.

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Association of Handgrip Strength with Diabetes Mellitus in Korean Adults According to Sex

Cited by 5 publications

References 43 publications

Association of handgrip strength with new-onset CKD in Korean adults according to gender

Association of handgrip strength with new-onset CKD in Korean adults according to gender

Aktivitas Fisik Penderita Diabetes Mellitus Terhadap Nilai Handgrip Strength Test

Relationship between Handgrip Strength and Incident Diabetes in Korean Adults According to Gender: A Population-Based Prospective Cohort Study

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