Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

Hwang, Yu-Jin; Ahn, Hong Yup; Park, Sung Woo; Park, Cheol‐Young

doi:10.1530/eje-14-0195

Cited by 31 publications

(32 citation statements)

References 28 publications

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“…However, this association has not been found to be consistent in previous studies [22][23][24][25] although previous research suggested that ApoA1 affects glucose metabolism via multiple mechanisms, including enhanced insulin secretion [26], increased insulin-independent glucose uptake in muscle and adipose tissues [27,28], improved insulin sensitivity [29], and reversed adipocyte dysfunction [30] and restored adiponectin expression and insulin sensitivity [31] with ApoA1 mimetic peptide. Furthermore, genetic studies suggested that genetic variation in ABCA1 has been associated with the increased risk of T2DM [32], and one study suggested that loss-of-function mutations in ABCA1 were associated with impaired b-cell function, but not with the development of T2DM [33].…”

Section: Discussionmentioning

confidence: 49%

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

Wu¹,

Yu²

2016

J Diabetes Metab

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Aims: Type-2 diabetes mellitus (T2DM) has become a major public health crisis in China. We examined the incidence of new T2DM over 4 years for association of clinical factors and lipids with development of T2DM in a community-based population. Methods:We included 923 Chinese subjects who participated in community-organized health checkout in both 2009 and 2013. Health history was collected; physical examination was performed; biochemistry, lipids and glucose were measured. Of 923, 819 were confirmed without T2DM in 2009 and included in the analysis.Results: Sixty-five subjects without T2DM in 2009 were identified as having new T2DM in 2013, 8% (65/819) over 4 years. These 65 subjects, compared to those 754 without new T2DM, were older, more likely to be male and smokers. They had higher BMI, fasting glucose, blood pressure and triglycerides, and lower levels of HDL-C and ApoA1. Multivariate logistic regression identified larger BMI (OR=1.7, 95%CI 1.22-2.39, p=0.002), higher fasting glucose (OR=4.2, 95%CI 2.90-6.19, p<0.001) and low levels of ApoA1 (OR=0.51, 95%CI 0.33-0.76, p=0.002) were independently associated with development of T2DM over 4 years. ROC curves for new T2DM showed that AUC improved from 0.87 to 0.89 when adding ApoA1 to the Framingham Diabetes Risk Model and from 0.85 to 0.89 when adding ApoA1 to a Chinese model. Conclusions:This study showed a high incidence of new T2DM at 8% over 4 years among Chinese and demonstrated a significant and independent association of higher BMI and glucose levels, and lower levels of ApoA1 with development of T2DM.

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Section: Discussionmentioning

confidence: 49%

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

Wu¹,

Yu²

2016

J Diabetes Metab

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“…In the case of low‐density lipoprotein (LDL), concomitant measure of its major lipoprotein, namely, apolipoprotein B 100 (apoB), has clarified the epidemiological risk related to LDLs of different sizes and densities, and it would therefore appear relevant to also adjust HDL‐C to its major apolipoprotein, namely, apolipoprotein A‐I (apoA‐I). The easiest way to combine these 2 measures is to calculate their ratio [HDL‐C/apoA‐I], bearing in mind that unlike the single molecular ratio of apoB 100 vis‐à‐vis LDL, discoidal or spherical mature HDLs carry 2 or 4 apoA‐Is per particle . Such a ratio allows not only to estimate an average size for HDLs but also to derive useful indices of HDL number, cholesterol load, and density.…”

Section: Introductionmentioning

confidence: 99%

[HDL‐C/apoA‐I]: A multivessel cardiometabolic risk marker in women with T2DM

Hermans

Valensi

Ahn

et al. 2017

Diabetes Metabolism Res

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Aims: Although women have higher high-density lipoprotein cholesterol (HDL-C) than have men, their HDL particles are also prone to become small, dense, and dysfunctional in case of type 2 diabetes mellitus (T2DM). To assess the vascular risk related to HDLs of different sizes/densities without direct measurement, we adjusted HDL-C to its main apolipoprotein Results: An adverse cardiometabolic profile characterized QI and QII patients whose HDLs were denser and depleted in apoA-I, whereas QIII patients had HDLs with characteristics closer to those of controls. QIV patients had HDLs of supernormal size/composition and a more favourable phenotype in terms of fat distribution; insulin sensitivity (64% vs 41%), metabolic syndrome, and β-cell function (32% vs 23%); exogenous insulin (44 vs 89 U·d −1 ); and glycaemic control (glycated haemoglobin, 56 vs 61 mmol·mol −1 ), associated with lower prevalence of microvascular/macrovascular complications: all-cause microangiopathy 47% vs 61%; retinopathy 22% vs 34%; all-cause macroangiopathy 19% vs 31%; and coronary artery disease 6% vs 24% (P < .05). Conclusion:[HDL-C/apoA-I] can stratify T2DM women according to metabolic phenotype, macrovascular and coronary damage, β-cell function, microangiopathic risk, and retinopathy. This ratio is a versatile and readily available marker of cardiometabolic status and vascular complications in T2DM women.

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“…However, in replacement therapy for hypothyroidism, the weight loss is very modest and due more to water deficit than to changes in body fat. Moreover, treatment of obese euthyroid patients with levothyroxine does not induce weight changes (1,2,3,4,5). …”

Section: Introductionmentioning

confidence: 99%

“…In obese subjects, slight increases have been observed in thyrotropin, or thyroid-stimulating hormone (TSH), but these are far from being the cause of overweight and could rather be a consequence of it (1,2,3,4,5). Although the origin of this increase in TSH in obese subjects is not fully understood and may be multifactorial, rather than being an indicator of subclinical hypothyroidism or of thyroid hormone resistance, it is currently considered to be an adaptive change, an attempt to increase basal metabolism in order to avoid further weight gain.…”

Section: Introductionmentioning

confidence: 99%

“…A low-grade inflammatory reaction mediated by interleukins and other adipokines may also be involved in these changes. In obese subjects, an ultrasound thyroid pattern of chronic low-grade inflammation (irregular hypoechoic areas) unaccompanied by any signs of autoimmunity and termed as “non-autoimmune thyroiditis from obesity” has been reported (1,2,3,5,15). …”

Section: Introductionmentioning

confidence: 99%

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Thyroid Function and Thyroid Autoimmunity in Relation to Weight Status and Cardiovascular Risk Factors in Children and Adolescents: A Population-Based Study

García-García

Vázquez-López²,

Garcı́a-Fuentes³

et al. 2016

Jcrpe

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Objective: In obese subjects, slight increases have been observed in thyrotropin [thyroid-stimulating hormone (TSH)] levels, but data in children are scarce. The aim of this study was to evaluate whether thyroid function and autoimmunity vary with weight status in a healthy population of children and adolescents and to determine whether hyperthyrotropinemia is associated with any cardiovascular risk factor.Methods: This cross-sectional epidemiological study was conducted in Almería (Spain) on a representative sample of 1317 healthy subjects aged 2-16 years. Thyroid function, thyroid autoimmunity and cardiovascular risk factors were measured. Chi-square test, analysis of variance and multiple linear regression were used in the statistical analyses.Results: The obese children and adolescents had thyrotropin levels (mean ± standard deviation) of 3.12±2.44 mU/L. These levels were higher than those of overweight subjects (2.79±1.51 mU/L) and of normal weight subjects (2.73±1.30 mU/L) (p=0.02). Levels of free thyroxine and urinary iodine did not differ significantly between the groups. The prevalence (95% confidence interval) of thyroid autoimmunity was lower in the individuals with normal weight (2.9%; 2.0-4.2) than in the overweight (6.3%; 3.9-9.9) and obese subjects (5.6%, 2.5-11.3) (p=0.02). TSH levels were associated with obesity (β=0.36; p<0.001) and thyroid autoimmunity (β=1.10; p<0.001). They were not associated with any cardiovascular risk factor.Conclusion: Obese children and adolescents had higher levels of thyrotropin than those who were overweight and of normal weight. The differences among the groups were of very little clinical significance and could possibly be linked to the higher prevalence of thyroid autoimmunity in obese subjects. The hyperthyrotropinemia in these subjects was not associated with any cardiovascular risk factor.

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Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

Cited by 31 publications

References 28 publications

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

Development of Type-2 Diabetes Mellitus is associated with Low Levels of ApoA1

[HDL‐C/apoA‐I]: A multivessel cardiometabolic risk marker in women with T2DM

Thyroid Function and Thyroid Autoimmunity in Relation to Weight Status and Cardiovascular Risk Factors in Children and Adolescents: A Population-Based Study

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