Association of heart rate profile during exercise with the severity of coronary artery disease

Çay, Serkan; Öztürk, Sezgin; Biyikoglu, Funda; Yıldız, Abdülkadir; Çi̇men, Tolga; Uygur, Belma; Tuna, Funda

doi:10.2459/jcm.0b013e328329c715

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Although there is an association between incompetence and myocardial ischemia 11 , the imbalance between oxygen supply-consumption in incompetent patients would not be so encouraged to the point of developing electrocardiographic abnormalities suggesting ischemia, as typically occurs in competent patients, which would decrease the sensitivity of ST in incompetent patients. In this study, the higher incidence of ST-segment depression was associated with lower odds of HF (OR = 0.58; p = 0.0003), similar to what was described by Cay et al 32 . Maddox et al 33 found ischemia on ECG in only 17% of incompetent patients, and Dresing al 27 , in 52% versus 65% of competent patients.…”

Section: -Specificitysupporting

confidence: 76%

Parâmetros clínicos e ecocardiográficos associados a baixo índice cronotrópico em pacientes não idosos

Secundo¹,

Santos²,

Júnior³

et al. 2012

Arq. Bras. Cardiol.

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Section: -Specificitysupporting

confidence: 76%

Parâmetros clínicos e ecocardiográficos associados a baixo índice cronotrópico em pacientes não idosos

Secundo¹,

Santos²,

Júnior³

et al. 2012

Arq. Bras. Cardiol.

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“…These factors may have increased the accuracy of regression analysis for prediction of SYNTAX score in our study. RHR is another measure of ANS function, and it was demonstrated that increased RHR, as well as decreased HR increment (maximum HR -RHR before exercise) and decreased HR decrement (maximum HR -RHR after exercise), are associated with the severity of CAD [24]. In another study including patients with SCAD, RHR was an independent predictor of SYNTAX score [25].…”

Section: Discussionmentioning

confidence: 99%

Decreased heart rate recovery may predict a high SYNTAX score in patients with stable coronary artery disease

Emren

Gediz

Şenöz

et al. 2019

Bosn J of Basic Med Sci

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An impaired heart rate recovery (HRR) has been associated with increased risk of cardiovascular events, cardiovascular, and all‐cause mortality. However, the diagnostic ability of HRR for the presence and severity of coronary artery disease (CAD) has not been clearly elucidated. Our aim was to investigate the relationship between HRR and the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score in patients with stable CAD (SCAD). A total of 406 patients with an abnormal treadmill exercise test and ≥50% coronary stenosis on coronary angiography were included. The HRR was calculated by subtracting the HR in the first minute of the recovery period from the maximum HR during exercise. The SYNTAX score ≥23 was accepted as high. Correlation of HRR with SYNTAX score and independent predictors of high SYNTAX score were determined. A high SYNTAX score was present in 172 (42%) patients. Mean HRR was lower in patients with a high SYNTAX score (9.8 ± 4.5 vs. 21.3 ± 9, p < 0.001). The SYNTAX score was negatively correlated with HRR (r: -0.580, p < 0.001). In multivariate logistic regression analysis, peripheral arterial disease (OR: 13.3; 95% CI: 3.120–34.520; p < 0.001), decreased HRR (OR: 0.780; 95% CI: 0.674–0.902; p = 0.001), peak systolic blood pressure (OR: 1.054; 95% CI: 1.023–1.087; p = 0.001), and peak HR (OR: 0.950; 95% CI: 0.923–0.977; p < 0.001) were found to be independent predictors of a high SYNTAX score. Our results showed that HRR is significantly correlated with the SYNTAX score, and a decreased HRR is an independent predictor of a high SYNTAX score in patients with SCAD.

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“…In their angiographic studies Çay et al (21), reported HRR has been related with severity of the CAD. We did not confirm our results by using invasive methods.…”

Section: Methodsmentioning

confidence: 97%

The Relationship Between GATED Myocardial Perfusion SPECT Findings and Heart Rate Recovery After Exercise Test

Erkan¹,

Yı́ldı́rı́m²,

Doğan³

2015

NileJMS

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Objective: Coronary artery disease has been thought that autonomic nervous system dysfunction especially increased sympathetic tonus and relatively decreased parasympathetic activity is related to coronary artery disease. Abnormal heart rate recovery after exercise test, is a simple available parameter, that reflects autonomic nervous system disfunction. GATED myocardial perfusion SPECT is used in the diagnosis and prognosis of coronary artery disease. In this study we compared heart rate recovery with myocardial perfusion scintigraphy findings.Methods: In our study there were 50 subjects (27 female, 23 male). Multiple lineer regression analysis was used to determine relationship between heart rate recovery and GATED myocardial perfusion SPECT parameters, age, gender, and history.Results: Multiple lineer regresion revealed strong independent negative assosiation between heart rate recovery and myocardial defect severity on stress images (β= -0.957; SE= 0.650; p= 0.043). Age was also an independent predictor of heart rate recovery with negative assosiation (β= -0.473; SE= 0.250; p= 0.022). Correlation coefficient (R) and R square (R2) of the model were 0.604, and 0.365 respectively.Conclusion: On stresss protocol, myocardial damage is more severe in patients who have decreased heart rate recovery. Since the severity of myocardial damage on stresss is a strong predictor of cardiac events and prognosis, heart rate recovery was also have prognostic value on future cardiac events.

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Association of heart rate profile during exercise with the severity of coronary artery disease

Abstract: Altered autonomic nervous system regulation affects heart rate profile, increased resting heart rate, decreased heart rate increment, and decreased heart rate decrement, during exercise and this effect is strongly and independently associated with the severity of coronary artery disease.

Cited by 7 publications

References 23 publications

Parâmetros clínicos e ecocardiográficos associados a baixo índice cronotrópico em pacientes não idosos

Parâmetros clínicos e ecocardiográficos associados a baixo índice cronotrópico em pacientes não idosos

Decreased heart rate recovery may predict a high SYNTAX score in patients with stable coronary artery disease

The Relationship Between GATED Myocardial Perfusion SPECT Findings and Heart Rate Recovery After Exercise Test

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