Association of Helicobacter pylori infection with the Lewis and ABO blood groups in dyspeptic patients

Abstract

Background:Helicobacter pylori infection is a basic risk factor for chronic gastritis, and gastric carcinoma. Based on some studies, the reason is binding of H. pylori to H and Leb antigens in gastric mucosa. However, some other findings have not determined any association between the infection and these antigens. Because of this controversy and the fact that H. pylori infection and gastric adenocarcinoma are common diseases in Iran, the assessment of the association of H. pylori infection with these blood groups could be valuable.Materials and Methods:In a cross sectional study on 135 adult dyspeptic patients in Mashhad, Iran, from 2009 to 2010, H. pylori infection was evaluated by using the Heliprobe 14C-urea breath test and the ABO and Lewis blood group antigens were determined by the tube method. Association between the Lewis and ABO phenotypes with H. pylori infection were analysed by Fisher's exact test. A P ≤ 0.05 was considered to be significant.Results:68 (50.4%) patients were positive for H. pylori infection. The frequencies of the ABO, Lewis and secretion phenotypes were not significant in the infected and non-infected patients. We also did not find a significant association between Lea and Leb antigens and this infection.Conclusion:We could not establish a significant association between the Lewis, ABO and secretion phenotypes with H. pylori infection. Diversity of sequences of blood group antigen b-binding adhesion (babA gene) of H. pylori may be a reason why our findings are different from other studies in other geographic areas.

Seroprevalence of Helicobacter pylori infection and its related risk factors in symptomatic patients in southern Ethiopia

“…In contrast, our finding was higher than other results reported from Ethiopia; 49 – 70% in Bahirdar [ 20 ], 56 – 70%) in Addis Ababa [ 25 , 26 ] and 66% in Gondar [ 27 ]. Also, the present result was found to be lower than the figures reported in Iran (46.6 – 64.8%) [ 18 , 28 , 29 ], Turkey (68%) [ 21 ], and in Portugal City of Coimbra (67%) [ 19 ]. The higher prevalence of H. pylori infection may be related to poor personal hygiene, low standard of living and low economic status among dyspeptic patients in the study area.…”

“…As to the relation between ABO blood group and H. pylori infection, contrasting evidences exists in which some studies revealed the presence of association [ 17 – 19 ], while others not [ 2 , 20 – 22 , 24 , 29 ]. Similar to the latter groups, we observed neither ABO nor Rh was significantly associated with infection in our study population, which challenges reports indicating participants with blood type O are more prone to H. pylori infection.…”

O Blood Group as a Risk Factor for Helicobacter pylori IgG Seropositivity among Pregnant Sudanese Women

“… 6 , 8 , 9 In contrast, other researchers could find no association between the ABO blood groups and H. pylori infection among an adult population in Mashhad, Iran. 13 , 14 However, both studies were carried in the same locality, a thing that might raise the possibility regarding an influencing effect of genetics of the group to the outcome, another plausible explanation could be the existence of different H. pylori strains in that locality as it has been documented by different studies that the different strains are not equally specific for O group. 27 , 28 Moreover, they used the urea breath test in one of the two studies, while they used antibody testing for H. pylori in the other study.…”

Association of ABO and Rh Blood Groups with Helicobacter pylori Seropositivity in Gonabad City, Iran: A Case-Control Study

“…One of the genetic risk factors is the expression of ABO blood group phenotypes in different people (11,12). These bacteria identify and bind to blood group antigens expressed on the surface of gastric mucosa and play an important role in the stability of infection (13,14). During colonization, H. pylori in the stomach bind to Lewis's antigens and type 1 antigen of the gastric mucosa.…”