Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria.

Nacher, Mathieu; Singhasivanon, Pratap; Phumratanaprapin, Weerapong; Silachamroon, Udomsak; Looareesuwan, Sornchai

doi:10.4269/ajtmh.2001.65.335

Cited by 41 publications

(39 citation statements)

References 11 publications

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“…In this regard, field studies on the clinical consequences of helminth-malaria coinfection in people [2,6,[8][9][10] would do well to take the lead from recent multivariate analyses of malaria immunoepidemiology [42][43][44][45]. Several of these previous studies have suggested that ratios of pro-to antiinflammatory factors predict disease severity [42,43,45], and one goes further to demonstrate that quantifiable relationships among proinflammatory cytokines, their soluble receptors, and malaria parasitemia together determine clinical outcome [44].…”

Section: Notementioning

confidence: 98%

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Malaria‐Filaria Coinfection in Mice Makes Malarial Disease More Severe unless Filarial Infection Achieves Patency

et al. 2005

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Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria. For example, type 1-dependent control of malaria parasitemia might be impaired by the type 2 milieu of preexisting helminth infection. Alternatively, immunomodulatory effects of helminths might affect the likelihood of malarial immunopathology. Using rodent models of lymphatic filariasis (Litomosoides sigmodontis) and noncerebral malaria (clone AS Plasmodium chabaudi chabaudi), we quantified disease severity, parasitemia, and polyclonal splenic immune responses in BALB/c mice. We found that coinfected mice, particularly those that did not have microfilaremia (Mf(-)), had more severe anemia and loss of body mass than did mice with malaria alone. Even when controlling for parasitemia, malaria was most severe in Mf(-) coinfected mice, and this was associated with increased interferon- gamma responsiveness. Thus, in Mf(-) mice, filariasis upset a delicate immunological balance in malaria infection and exacerbated malaria-induced immunopathology.

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Section: Notementioning

confidence: 98%

“…Interactions among infections commonly alter disease severity [6,7], and malaria-helminth coinfection can either exacerbate [8,9] or ameliorate [10] the severity of disease in human hosts. Various immunological mechanisms can be invoked to explain these diverse outcomes.…”

mentioning

confidence: 99%

Malaria‐Filaria Coinfection in Mice Makes Malarial Disease More Severe unless Filarial Infection Achieves Patency

et al. 2005

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“…Two studies on non-pregnant adults 8,29 assessed anemia using Hb cut-off level and reported a significantly higher risk of anemia in those co-infected with any STH compared with those not co-infected (summary OR: 2.2; 95% CI: 1.9-4.45; I 2 : 40%). Two studies (n¼624) 28,29 assessed the effect of co-infection on anemia and reported a significantly lower mean Hb level in the co-infected group compared with those not co-infected (mean difference (MD) 0.98; 95% CI:20.59 to 21.37; I 2 : 0%).…”

Section: Effect Of Co-infection On Anemiamentioning

confidence: 99%

“…Two studies (n¼624) 28,29 assessed the effect of co-infection on anemia and reported a significantly lower mean Hb level in the co-infected group compared with those not co-infected (mean difference (MD) 0.98; 95% CI:20.59 to 21.37; I 2 : 0%). Overall, among non-pregnant adults, a higher risk of anemia was found in the co-infected group, regardless of hematological outcome.…”

Section: Effect Of Co-infection On Anemiamentioning

confidence: 99%

Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis

Naing

Whittaker

Nyunt-Wai

et al. 2013

Transactions of the Royal Society of Tropical Medicine and Hygiene

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This study aimed to synthesize available evidence on the extent of malaria and soil-transmitted intestinal helminth (STH) co-infections in people living in endemic countries and to explore the effect of interactions between malaria and STHs on anemia. We searched relevant studies in electronic databases up to March 2013. Studies comparing malaria and STH co-infected patients with those not co-infected were included and the effect estimates were pooled using a random-effects model. We identified 30 studies for meta-analyses of which 17 were cross-sectional design. The majority of included studies (80%) were carried out in African countries. Among pregnant women, those infected with hookworm were found to have higher association with malaria infection compared with those without (summary OR: 1.36; 95% CI: 1.17-1.59; I 2 : 0%). Among nonpregnant adults, the summary OR of the association between anemia and the combined malaria and STH was 2.91 (1.38-6.14). The summary OR of the association between anemia and malaria alone was 1.53 (0.97-2.42), while the association between anemia and STH alone was 0.28 (0.04-1.95). There is no good evidence to support a different effect of malaria and STH on anemia. A subgroup analysis showed a higher risk of malaria infection in the primigravidae (summary OR: 1.61; 95% CI: 1.3-1.99; I 2 : 0%). In conclusion, the malaria-STH co-infection was variable with complex outcomes on anemia.

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“…Apart from causing morbidity and mortality, infection with pathogenic parasites of intestine has known to cause iron deficiency anemia, growth retardation in children and other physical and mental health problems. Also, chronic intestinal parasitic infections have been about the spreading and severity of other infectious diseases of viral origin, tuberculosis and malaria [5]. Low levels of health education, poor individual and public health, poor drinking water, overcrowded conditions and poor environmental sanitation increase the prevalence of giardiasis and enterobiasis [6,7].…”

Section: Introductionmentioning

confidence: 99%

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

Arbabi

Esmaili

Parastouei

et al. 2015

Zahedan J Res Med Sci

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Background: There are scant evidences between giardiasis and enterobiasis with human mal-absorption of micronutrient. Objectives: The aim of the present study was to found out the changes in the serum zinc, copper, magnesium and vitamin B12 levels in schoolchildren infected with Giardia intestinalis and Enterobius vermicularis. Patients and Methods: This case-control study was carried out among 359 children from aged 6 -12 years old at 8 suburban public schools. Three stool examinations were done using standard techniques for identification parasitic infection. Fifty E. vermicularis and 37 G. lamblia infected individuals were enrolled as study groups. Serum levels of copper, zinc, magnesium were assessed by autoanalyzer and vitamin B12 levels were measured using gamma counter. ANOVA and paired t-test analyses were used to determine the association between infections and trace elements changes. Results: The prevalence of G. intestinalis and E. vermicularis infections were 10.3% and 13.9%, respectively. The serum zinc, copper and magnesium levels showed a significant decrease in individuals infected with G. intestinalis and E. vermicularis (P < 0.05). Mean values of Giardia positive and negative groups for copper 143.65 ± 16.51 and 176.26 ± 17.6 μg/dL, zinc 62.26 ± 16.06 and 80.66 ± 23.58 μg/dL, and magnesium 1.82 ± 0.23 and 2.01 ± 0.16 mg/dL, respectively. Mean values of Enterobius positive and negative groups for copper 145.55 ± 26.84 and 176.26 ± 17.6 μg/dL, zinc 72.7 ± 17.92 and 80.66 ± 23.58 μg/dL and magnesium 1.93 ± 0.11 and 2.01 ± 0.16 mg/dL, respectively. Conclusions:The results showed that giardiasis and enterobiasis decreased serum levels of copper, zinc and magnesium. Further studies are needed to clarify the actual mechanism governing the zinc, copper, magnesium and vitamin B12 giardiasis/enterobiasis interaction.

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Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria.

Cited by 41 publications

References 11 publications

Malaria‐Filaria Coinfection in Mice Makes Malarial Disease More Severe unless Filarial Infection Achieves Patency

Malaria‐Filaria Coinfection in Mice Makes Malarial Disease More Severe unless Filarial Infection Achieves Patency

Malaria and soil-transmitted intestinal helminth co-infection and its effect on anemia: a meta-analysis

Levels of Zinc, Copper, Magnesium Elements, and Vitamin B12, in Sera of Schoolchildren With Giardiasis and Entrobiosis in Kashan, Iran

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