Association of hematology profile with serum 25-hydroxy vitamin D and Bsml polimorphism in community-dwelling older adults

Abstract

A B S T R A C T ObjectiveTo investigate the association between serum level of 25-hydroxy vitamin D and the Vitamin D Receptos gene BsmI polymorphism in the blood profile of community-dwelling older adults. MethodsThis cross-sectional study included 142 older males and females. A questionnaire collected socio demographic information, medical history, and factors associated with sun exposure. Weight, height, and waist circumference were measured. Biological material was collected to analyze biochemical parameters 25-hydroxy vitamin D, parathormone, serum calcium, urea, creatinine, liver enzymes, and blood profile) and to verify the presence of the vitamin D receptos gene BsmI polymorphism. ResultsMost participants were female (80.3%). The mean levels of 25-hydroxy vitamin D, hemoglobin, and hematocrit were 32.1±7.3 ng/dL, 13.5±1.5 d/dL, and 40.0±4.4%, respectively. Fifty-eight (40.8%) participants had vitamin

Association between hematological profile and serum 25-hydroxyvitamin D levels and FokI polymorphism in individuals with cystic fibrosis

“…Recently, Silva et al [25] investigated the association between hematological profile and serum 25-(OH)D levels and the BsmI polymorphism of the VDR gene in noninstitutionalized elderly patients, thus showing that vitamin D deficiency is associated with low hemoglobin levels. The influence of nutritional status on anemia was assessed in this group, and no association was observed.…”

“…The discovery that most of the body tissues and cells contain vitamin D receptors and that several of these tissues have the enzymatic property to convert the primary form of vitamin D in the circulation to its active form has provided new insights about the function of this steroid hormone [10]. In addition, the concentration of 1,25-hydroxyvitamin D (1,25[OH]D) is a hundred times greater in the bone marrow than in the plasma. The clinical consequences of its deficit have been a topic of interest due to the new insights about the biological functions of vitamin D, and the hypotheses that there is an association between vitamin D and hemoglobin levels and that this phenomenon may be influenced by polymorphisms in the Vitamin D Receptor gene (VDR) have been reinforced [11,12].…”