Association of Hematuria on Microscopic Urinalysis and Risk of Urinary Tract Cancer

Abstract

The incidence of urinary tract cancer is low even in individuals with microhematuria. Thus, current best policy recommendations do not perform well. Since older age, male gender and greater hematuria are associated with a higher risk of cancer, future studies should evaluate strategies that target these populations.

Identification of Patients with Microscopic Hematuria who are at Greater Risk for the Presence of Bladder Tumors Using a Dedicated Questionnaire and Point of Care Urine Test - A Study by the Members of Association of Urooncology, Turkey

“…It may be due to a multitude of urological problems however urothelial carcinoma of the bladder (UC) is probably the most significant one which is a major health problem across the world. Although not all patients are at the same risk for UC, approximately 3 % of male patients above the age of 40 with microscopic hematuria may have bladder cancer (Jung et al, 2011). Thus, microscopic hematuria, as a screening test for bladder cancer, has a limited effectiveness (Khadra et al, 2000).…”

Comparison of Nmp22 Urinary Marker Test and Urine Cytology in the Early Detection of Recurrent Transitional Cell Carcinoma of Urinary Bladder

“…The mean time since diagnosis of transitional cell carcinoma (TCC) of the bladder was 12 months (range 3-36 months). The mean number of previous recurrences was 1.6 (range 0-3 (32) 0.53 81.8 (9/11) 90.9 (10/11) G3 (11) When tumors were stratified by T stage, NMP22 was more sensitive than cytology in detecting Ta and T1 tumors (83% versus 46%, P < 0.05). Interestingly, all three T2 stage recurrences were detected by both the NMP22 test and cytology (Table3).…”

“…[10] Hematuria is the most common presentation of patients, either microscopic or macroscopic. [11] Urinary cytology Examination of voided urine or bladder-washing specimens for exfoliated cancer cells has high sensitivity in high-grade tumors but low sensitivity in low-grade tumors, The sensitivity of cytology for CIS detection is 28-100%. [12] up, markers for recurrent urothelial cancer would be especially useful and will be discussed later in more details.…”

High-grade microscopic hematuria in adult men can predict urothelial malignancy

“…1 Causes of microscopic hematuria are variable and include urinary stones, infection and genitourinary malignancy. 2 Jung and colleagues 3 conducted a large retrospective study on 156 691 patients with hematuria and the authors wanted to assess its association with urological cancer. They found that older age groups, male sex and hematuria greater than 25 RBC/HPF was significantly associated with a higher risk of urological malignancy.…”