Association of hepatitis C infection and acute coronary syndrome

Wu, Angela; Burrowes, Shana A B; Zisman, Erin; Brown, Todd T.; Bagchi, Shashwatee

doi:10.1097/md.0000000000026033

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…In another study, Butt et al reported that despite the presence of favorable lipid profile in patients infected with HCV, HCV infection was associated with greater risk of coronary artery disease with a hazard ratio of 1.27 (95% CI, 1.22-1.31) after adjustment of conventional risk factors [109]. Interestingly, a recent case-control study found contradicting results, in which there was no statistically significant association between HCV infection and acute coronary syndrome in the study population [110]. Several studies have examined the potential association between HCV infection and cerebrovascular events.…”

Section: Accelerated Atherosclerosismentioning

confidence: 94%

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Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact

2023

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Hepatitis C virus (HCV) infection represents the major cause of chronic liver disease, leading to a wide range of hepatic diseases, including cirrhosis and hepatocellular carcinoma. It is the leading indication for liver transplantation worldwide. In addition, there is a growing body of evidence concerning the role of HCV in extrahepatic manifestations, including immune-related disorders and metabolic abnormalities, such as insulin resistance and steatosis. HCV depends on its host cells to propagate successfully, and every aspect of the HCV life cycle is closely related to human lipid metabolism. The virus circulates as a lipid-rich particle, entering the hepatocyte via lipoprotein cell receptors. It has also been shown to upregulate lipid biosynthesis and impair lipid degradation, resulting in significant intracellular lipid accumulation (steatosis) and circulating hypocholesterolemia. Patients with chronic HCV are at increased risk for hepatic steatosis, dyslipidemia, and cardiovascular disease, including accelerated atherosclerosis. This review aims to describe different aspects of the HCV viral life cycle as it impacts host lipoproteins and lipid metabolism. It then discusses the mechanisms of HCV-related hepatic steatosis, hypocholesterolemia, and accelerated atherosclerosis.

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Section: Accelerated Atherosclerosismentioning

confidence: 94%

“…Wu et al [110], 2021 Acute coronary syndrome There was no statistically significant correlation between HCV infection and hospitalization for acute coronary syndrome.…”

Section: Morales Et Al [76] 2016mentioning

confidence: 95%

Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact

2023

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“…Данные о роли других заболеваний печени, прежде всего хронического вирусного гепатита В и С, в развитии коронарного атеросклероза и ОКС неоднозначны. Некоторые авторы не выявили повышенного риска развития ИМ у пациентов с HCV-инфекцией [32,33], однако в другом исследовании HCV-инфекция сопровождалась значительным увеличением риска ИМ 2 типа (скорректированное отношение рисков 1,46, 95% ДИ 1,09-1,97), но не ИМ 1 типа [34]. По данным анализа 686 HCV-позитивных пациентов, вирусная инфекция оказалась независимым предиктором ангиографически подтвержденного поражения коронарных артерий (скорректированное ОШ 4,2; 95% ДИ 1,4-13,0) [35].…”

Section: материалы и методыunclassified

Features of myocardial infarction with ST segment elevation in patients with non-alcoholic liver steatosis and steatohepatitis

Tretyakova,

Ermilov,

Alferov

2023

CPT

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“…This effect was hypothesized when HCV + was found to be associated with the presence of CAD, which remained significant even after correction for cardiometabolic risk factors, and which was associated with the severity of disease (number of diseased vessels) [134]. Many further investigations have confirmed this link, whereas others have found no significant relationship [135][136][137]. As a result, the balance of these data ranges widely from no correlation to a favorable relationship.…”

Section: Potential Mechanisms Linking Hcv To Atherosclerosismentioning

confidence: 99%

Viral infections in cardiometabolic risk and disease between old acquaintances and new enemies

Vassalle

2023

Explor Cardiol

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Atherosclerosis is a chronic disease, characterized by chronic inflammation, endothelial dysfunction, and lipid deposition in the vessel. Although many major, well-identified risk factors for atherosclerosis [e.g., hyperlipidemia, hypertension, type 2 diabetes (T2D), smoking habit, and obesity] explain a lot about the risk, there is a considerable number of patients who develop atherosclerotic damage and undergo adverse events without presenting any of these established modifiable risk factors. This observation has stimulated an urgent need to expand knowledge towards the identification of additional, less established risk factors that may help in the assessment of risk and fill the gap of knowledge in the cardiovascular (CV) setting. Among them, the hypothesis of a possible relationship between viral infectious agents and atherosclerosis has risen since the early 1900s. However, there is still a great deal of debate regarding the onset and progression of CV disease in relation to the roles of the pathogens (as active inducers or bystanders), host genomic counterparts, and environmental triggers, affecting both virus abundance and the composition of viral communities. Accordingly, the aim of this review is to discuss the current state of knowledge on infectious agents in the atherosclerotic process, with particular focus on two environmental-related viruses, as examples of familiar (influenza) and unfamiliar [severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)] disease triggers.

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Association of hepatitis C infection and acute coronary syndrome

Abstract: Supplemental Digital Content is available in the text

Cited by 3 publications

References 12 publications

Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact

Hepatitis C Virus-Lipid Interplay: Pathogenesis and Clinical Impact

Features of myocardial infarction with ST segment elevation in patients with non-alcoholic liver steatosis and steatohepatitis

Viral infections in cardiometabolic risk and disease between old acquaintances and new enemies

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