2019
DOI: 10.12788/jhm.3202
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Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis

Abstract: Although neonatal herpes simplex virus (HSV) causes significant morbidity, utilization of the cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) test remains variable. Our objective was to examine the association of CSF HSV PCR testing with length of stay (LOS) in a 20-center retrospective cohort of hospitalized infants aged ≤60 days undergoing evaluation for meningitis after adjustment for patient-level factors and clustering by center. Of 20,496 eligible infants, 7,399 (36.1%) had a CSF HSV PCR te… Show more

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Cited by 8 publications
(2 citation statements)
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“…Nationally, rates of HSV testing vary significantly 7 . HSV testing has been associated with a 23% longer length of stay; however, this increase in resource utilization should be balanced with the decreased risk of morbidity and mortality 10,11,13 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Nationally, rates of HSV testing vary significantly 7 . HSV testing has been associated with a 23% longer length of stay; however, this increase in resource utilization should be balanced with the decreased risk of morbidity and mortality 10,11,13 …”
Section: Discussionmentioning
confidence: 99%
“…7 HSV testing has been associated with a 23% longer length of stay; however, this increase in resource utilization should be balanced with the decreased risk of morbidity and mortality. 10,11,13 MANAGEMENT Acyclovir is the only recommended treatment for neonatal HSV disease and should be started empirically in any patient with clinical suspicion. Before antiviral therapy, mortality from CNS disease and disseminated disease was 50% and 85%, respectively.…”
Section: Discussionmentioning
confidence: 99%