Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis

Xie, Wanting; Zhang, Liuwei; Wang, Jiawei; Wang, Yirui

doi:10.1007/s10528-023-10385-x

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Nevertheless, polymorphism of the SLC30A8 gene has been examined in the context of GDM and pancreatic beta-cell survival and function [ 12 , 31 ]. In their recent meta-analysis, Xie et al [ 32 ] demonstrated that allele C of the rs13266634 polymorphism was significantly associated with GDM susceptibility. Interestingly, autoantibodies targeting the protein encoded by SLC30A8 (zinc transporter 8) have been found in patients with GDM, but their clinical relevance is unclear [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes

Ustianowski,

Czerewaty,

Kiełbowski

et al. 2024

JCM

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Background/Objectives: Gestational diabetes (GDM) is a metabolic disorder with altered glucose levels diagnosed in pregnant women. The pathogenesis of GDM is not fully known, but it is thought to be caused by impaired insulin production and insulin resistance induced by diabetogenic factors. The placenta may play an important role in the development of GDM. Glucose transporters (GLUTs) are responsible for the delivery of glucose into the foetal circulation. Placental zinc transporters regulate insulin and glucagon secretion, as well as gluconeogenesis and glycolysis. The aim of this study was to investigate the placental expression of GLUT3, GLUT4, GLUT7 and SLC30A8 in women with GDM. Furthermore, we evaluated whether the expression profiles of these transporters were correlated with clinical parameters. Methods: This study included 26 patients with GDM and 28 patients with normal glucose tolerance (NGT). Results: The placental expression of GLUT3 was significantly reduced in the GDM group, while the placental expression of GLUT4, GLUT7 and SLC30A8 was significantly upregulated in the GDM group. GLUT3 expression correlated significantly with body mass index (BMI) increase during pregnancy and body mass increase during pregnancy, while GLUT4 expression correlated negatively with BMI at birth. Conclusions: These results suggest the involvement of GLUT3 and GLUT4, GLUT7 and SLC30A8 in the pathogenesis of GDM.

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Section: Discussionmentioning

confidence: 99%

Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes

Ustianowski,

Czerewaty,

Kiełbowski

et al. 2024

JCM

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Section: Hhexmentioning

confidence: 97%

“…HHEX variants rs1111875 (T > C), rs5015480 (T > C), and rs7923837 (A > G) were associated with increased susceptibility to GDM [25][26][27]. All three SNPs are in the intergenic region of the IDE-KIF11-HHEX LD block, in which the closest gene is HHEX [25]. However, in silico studies, such as cis-expression quantitative trait locus (cis-eQTL), which linked SNPs to HHEX, have never been confirmed.…”

Section: Hhexmentioning

confidence: 98%

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Suthon,

Tangjittipokin

2024

IJMS

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Gestational diabetes mellitus (GDM) is a significant pregnancy complication linked to perinatal complications and an elevated risk of future metabolic disorders for both mothers and their children. GDM is diagnosed when women without prior diabetes develop chronic hyperglycemia due to β-cell dysfunction during gestation. Global research focuses on the association between GDM and single nucleotide polymorphisms (SNPs) and aims to enhance our understanding of GDM’s pathogenesis, predict its risk, and guide patient management. This review offers a summary of various SNPs linked to a heightened risk of GDM and explores their biological mechanisms within the tissues implicated in the development of the condition.

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“…They are related to the occurrence of GDM. For example, several GDM risk genes were found to have functions in glucose metabolism, insulin synthesis and secretion, and insulin signaling through family linkage analysis and genome-wide association studies ( Xie et al., 2023 ). In addition, researchers explored the susceptibility genes of GDM through case-control studies and found that genes such as TCF7L2, VDR, and IGF2BP2 serve multiple functions such as β-cell function, insulin secretion, peripheral insulin resistance, glucose metabolism, and oxidative stress, conferring genetic susceptibility to GDM ( Wei et al., 2021 ).…”

Section: Etiology and Factors Affecting Gdmmentioning

confidence: 99%

Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review

Ma,

Wang,

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionGestational diabetes mellitus (GDM) is a form of gestational diabetes mellitus characterized by insulin resistance and abnormal function of pancreatic beta cells. In recent years, genomic association studies have revealed risk and susceptibility genes associated with genetic susceptibility to GDM. However, genetic predisposition cannot explain the rising global incidence of GDM, which may be related to the increased influence of environmental factors, especially the gut microbiome. Studies have shown that gut microbiota is closely related to the occurrence and development of GDM. This paper reviews the relationship between gut microbiota and the pathological mechanism of GDM, in order to better understand the role of gut microbiota in GDM, and to provide a theoretical basis for clinical application of gut microbiota in the treatment of related diseases.MethodsThe current research results on the interaction between GDM and gut microbiota were collected and analyzed through literature review. Keywords such as "GDM", "gut microbiota" and "insulin resistance" were used for literature search, and the methodology, findings and potential impact on the pathophysiology of GDM were systematically evaluated.ResultsIt was found that the composition and diversity of gut microbiota were significantly associated with the occurrence and development of GDM. Specifically, the abundance of certain gut bacteria is associated with an increased risk of GDM, while other changes in the microbiome may be associated with improved insulin sensitivity. In addition, alterations in the gut microbiota may affect blood glucose control through a variety of mechanisms, including the production of short-chain fatty acids, activation of inflammatory pathways, and metabolism of the B vitamin group.DiscussionThe results of this paper highlight the importance of gut microbiota in the pathogenesis of GDM. The regulation of the gut microbiota may provide new directions for the treatment of GDM, including improving insulin sensitivity and blood sugar control through the use of probiotics and prebiotics. However, more research is needed to confirm the generality and exact mechanisms of these findings and to explore potential clinical applications of the gut microbiota in the management of gestational diabetes. In addition, future studies should consider the interaction between environmental and genetic factors and how together they affect the risk of GDM.

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Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational Diabetes Mellitus Susceptibility: A Meta-analysis

Cited by 6 publications

References 59 publications

Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes

Placental Expression of Glucose and Zinc Transporters in Women with Gestational Diabetes

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review

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