Association of High Density Lipoprotein with Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in Coronary Artery Disease Patients

Abstract

Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients. Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected. Results. We have observed significant association between HDL and PLR (P = 0.008) and NLR (P = 0.009); however no significant relationship was obtained with HDL and isolated platelet (P = 0.488), neutrophil (P = 0.407), and lymphocyte (P = 0.952) counts in CAD patients. The association was subjected to gender specific variation as in males PLR (P = 0.024) and NLR (P = 0.03) were highly elevated in low HDL patients, whereas in females the elevation could not reach the statistically significant level. The PLR (217.47 versus 190.3; P = 0.01) and NLR (6.33 versus 5.10; P = 0.01) were significantly higher among the patients with acute coronary syndrome. In young patients the PLR (P = 0.007) and NLR (P = 0.001) were inversely associated with HDL, whereas in older population only NLR (P = 0.05) had showed a significant association. Conclusion. We conclude that PLR and NLR are significantly elevated in CAD patients having low HDL levels.

Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: A retrospective study

“…In addition, NLR is associated with pro-inflammatory mediators (high sensitive CRP, tumor necrosis factor-α) and progressive subclinical atherogenesis [24].A high NLR is a predictor of atherosclerosis progression [10,25,26] and long-term prognosis in patients after PCI [12]. As a protective factor for blood vessels, HDL-C has been observed in both healthy people [14] and CAD patients [15] as associated with NLR levels at lower levels. However, few authors have focused on the relationship between variability in blood lipids and NLR.…”

Correlations between hematological indicators and other known markers in acute coronary syndromes

“…(18) As essential components of coronary thrombus formation, platelets play an important role in ACS. (2) In the CADILLAC study, increased platelet counts were also associated with restenosis and stent thrombosis.…”

“…(4) In their meta-analysis, Li et al showed that increased PLR is associated with in hospital and long-term mortality and cardiovascular events in ACS patients. ( (18) The combined use of NLR and PLR suggests that more prognostic information will be obtained. In this context, Choi et al found that combined NLR and PLR elevations were associated with long-term cardiovascular events (22).…”

Prognostic Value of Pretreatment Circulating Neutrophils, Monocytes, and Lymphocytes on Outcomes in Lung Stereotactic Body Radiotherapy

“…A recent meta-analysis of 13,964 patients participating in twenty-six studies demonstrated that elevated platelet:lymphocyte ratio (plr) is a negative predictor for overall survival (os) with a hazard ratio of 1.60 [95% confidence interval (ci): 1.35 to 1.90; p < 0.01) 8 . High neutrophil:lymphocyte ratio (nlr) has also been shown to have poor prognostic implications in patients with chronic medical conditions such as coronary artery disease 9 and end-stage renal disease 10 . Utilizing prognostic indicators obtained from a complete blood count (cbc) to inform decision-making in patients with early-stage lung cancer considering sbrt is attractive, given that it is readily obtained, minimally invasive, and low cost.…”