Association of High Levels of Testosterone and Ferritin with Overweight in Women with PCOS

Abstract

Background & Objective: The present study was conducted to determine testosterone and ferritin levels in women with polycystic ovary syndrome (PCOS) and investigate its relationship with body mass index (BMI)
 Materials & Methods: In this case-control study, 104 PCOS cases and 99 controls were included. The concentration of testosterone, ferritin, lipid profile, insulin, glucose, and androgen was measured in fasting blood samples.
 Results: Testosterone level was equal to 1.08 ± 0.50 and 0.85 ± 0.42 in the case and control groups, respectively (P< 0.001). Values of ferritin (123.45 ± 18.21ng/dl vs. 92.14 ± 17.74 ng/dl in control group, p< 0.001), insulin (11.41 ± 3.84 µU/ml vs. 7.02 ± 3.29 µU/ml in control group, p< 0.001), and insulin resistance (11.41 ± 3.84 vs.7.02 ± 3.29 in control group, p< 0.001) were also measured. There was a significant relationship between serum concentration of testosterone and ferritin with BMI) p<0.001). The role of ferritin to predict PCOS was significant (ß:-1.1, P< 0.001).
 Conclusion: According to the findings of the present study, the levels of testosterone and ferritin were increased in patients with PCOS. Although elevated testosterone levels are effective in PCOS, ferritin concentration is an important factor in predicting and exacerbating the disease.

PCOS In Females is independent of Ferritin and Minerals Levels

“…This study found that serum ferritin concentration did not appear to change in women with PCOS. Our results were incompatible with Barartabar et al (1) who revealed that ferritin levels in serum were elevated in PCOS women and PCOS women with obesity.…”

“…The most communal endocrinopathy in females of reproductive age (15-44 years) is Polycystic ovary syndrome (PCOS), with an incidence of 5-10% (1). Polycystic ovary syndrome influences numerous systems and have several complications like irregular menses, infertility, insulin resistance, acanthosis nigricans, hir¬sutism, and obesity.…”

Assessment of Monocyte Chemoattractant Protein -1 and Fertility Hormones in Iraqi Women with Polycystic Ovarian Syndrome

“…Testosterone levels in the current research were elevated significantly (P<0.05) in the PCOS group compared to the control group, and this rise may be due to obesity, particularly abdominal obesity, and insulin resistance, which are linked to elevated blood testosterone levels. As a result of increased androgen and insulin resistance in PCOS patients, testosterone production in the ovaries rises [35]. Also, this increase mostly results from the inherent alteration of ovarian theca cells, characterized by a disruption in the expression and/or activity of essential steroidogenic enzymes [36].…”