Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico

Parra-Colín, Paola de la; Pichardo-Bahena, Raúl; Méndez-Martínez, Rocío; García‐Carrancá, Alejandro; Barrientos‐Gutiérrez, Tonatiuh; Santamaría‐Olmedo, Mónica; Lazcano-Ponce, Eduardo; Hidalgo‐Bravo, Alberto

doi:10.21149/12796

“…Aunque el papiloma ocular puede afectar a personas de todas las edades, algunos estudios indican que los adultos jóvenes y de mediana edad parecen tener una mayor incidencia en comparación con otros grupos de edad. Sin embargo, es importante tener en cuenta que esta enfermedad puede presentarse en cualquier edad y no está limitada solo a estos grupos (7).…”

Section: Epidemiologíaunclassified

Papiloma ocular: una mirada profunda a la enfermedad ocular y su manejo

Lilliana Marcela,

González Alfaro,

Salazar Porras

2023

Rev.méd.sinerg.

0

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El papiloma ocular es una enfermedad que afecta al ojo y se origina a partir de la infección del virus del papiloma humano (VPH) en la conjuntiva, una membrana que recubre la parte blanca del ojo y los párpados. Como resultado de esta infección viral, se forman protuberancias o verrugas en la superficie ocular. Los síntomas del papiloma ocular pueden variar en intensidad y presentación, pero comúnmente incluyen enrojecimiento ocular, irritación, sensación de cuerpo extraño, picazón y visión borrosa. Estas protuberancias pueden ser únicas o múltiples, y su tamaño puede oscilar desde pequeñas lesiones hasta crecimientos más grandes. El tratamiento del papiloma ocular generalmente implica la eliminación quirúrgica de las verrugas o protuberancias. Para ello, se utilizan diversos métodos como el raspado, la escisión con láser o la crioterapia (congelación), siendo la elección del método dependiente del tamaño, la ubicación y las características específicas de las lesiones oculares. En algunos casos, se pueden recetar medicamentos tópicos para reducir la probabilidad de recurrencia de las verrugas. Es importante destacar que el papiloma ocular puede presentar un riesgo potencial de transformación maligna. Algunas verrugas pueden volverse cancerosas y desarrollar un carcinoma de células escamosas conjuntival. Por esta razón, se recomienda realizar un seguimiento periódico después del tratamiento, a fin de detectar cualquier signo de recurrencia o cambio maligno. En cuanto a la prevención del papiloma ocular, se centra en evitar la exposición al virus del papiloma humano. Esto implica practicar sexo seguro y evitar el contacto directo con las lesiones de la piel o membranas mucosas de personas infectadas. Además, mantener una buena higiene ocular y evitar compartir productos de cuidado personal relacionados con los ojos, como toallas o cosméticos, puede contribuir a la prevención de la enfermedad.

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Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

Hӧllhumer

¹

,

Michelow

²

,

Williams

³

2023

Eye

9

0

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Aims The aim of this study is to describe the demographic, presenting features and associated risk factors of ocular surface squamous neoplasia (OSSN) at a tertiary eye hospital in Johannesburg, South Africa. Methods An interventional prospective study of patients presenting with conjunctival masses was conducted. An electronic questionnaire was completed to document demographic data, presenting history, and associated risk factors. A slit lamp examination and photos were used to document and describe the clinical features at presentation. Cases (OSSN) and controls (benign lesions) were determined by histology. Results There were 130 cases and 45 controls. Median age was 44 years (IQR: 35–51) with an equal gender distribution in cases. The prevalence of HIV in cases was 74% and was strongly associated with OSSN (p < 0.001). Vascularisation, leukoplakia and pigmentation were clinical features that distinguished cases from controls. A fibrovascular morphology was strongly associated with a benign histology (p < 0.001), whereas leukoplakic and gelatinous morphologies were associated with OSSN. Conjunctival intra-epithelial neoplasia made up 82% of cases. Conclusion Our study describes a sample of OSSN that is young and has no gender predisposition. The majority of cases presented with CIN lesions, rather than SCC reported in other African countries. HIV was the most significant risk factor in this study population.

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Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

Hӧllhumer

¹

,

Williams

²

,

Michelow³

2022

Preprint

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Aims The aim of this study is to describe the demographic, presenting features and associated risk factors of ocular surface squamous neoplasia (OSSN) at a tertiary eye hospital in Johannesburg, South Africa. Methods An interventional prospective study of patients presenting with conjunctival masses was conducted. An electronic questionnaire was completed to document demographic data, presenting history, and associated risk factors. A slit lamp examination and photos were used to document and describe the clinical features at presentation. Cases (OSSN) and controls (benign lesions) were determined by histology. Results There were 130 cases and 45 controls. Median age was 44 years (IQR: 35–51) with an equal gender distribution in cases. The prevalence of HIV in cases was 74% and was strongly associated with OSSN (p < 0.001). Vascularisation, leukoplakia and pigmentation were clinical features that distinguished cases from controls. A fibrovascular morphology was strongly associated with a benign histology (p < 0.001), whereas leukoplakic and gelatinous morphologies were associated with OSSN. Conjunctival intra-epithelial neoplasia made up 82% of cases. Conclusion Our study describes a sample of OSSN that is young and has no gender predisposition. The majority of cases presented with CIN lesions, rather than SCC reported in other African countries. HIV was the most significant risk factor in this study population.

show abstract

Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico

Cited by 4 publications

References 34 publications

Papiloma ocular: una mirada profunda a la enfermedad ocular y su manejo

Papiloma ocular: una mirada profunda a la enfermedad ocular y su manejo

Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

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