Association of High Sensitivity C-Reactive Protein With Coronary Heart Disease Prediction, but not With Carotid Atherosclerosis, in Patients With Hypertension

Choi, Hyun-Woo; Cho, Dong Hee; Shin, Hyun Ho; Park, Jeong Bae

doi:10.1253/circj.68.297

Cited by 67 publications

(55 citation statements)

References 32 publications

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“…5,6,17 IL-6 and hs-CRP were also suggested to be strong independent predictors of the risk of future cardiovascular events. [28][29][30][31][32][33][34] The present study, which shows a relationship between carotid haemodynamic change and inflammatory markers, indicates that PI and RI could also help to predict further cardiovascular events.…”

Section: Discussionmentioning

confidence: 88%

Association between carotid haemodynamics and inflammation in patients with essential hypertension

et al. 2005

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Previous studies have shown that high blood pressure causes chronic inflammation. Hypertensive patients are reported to have high-circulating levels of proinflammatory cytokines such as interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP). The pulsatility index (PI) and resistive index (RI) are used as markers of peripheral vascular resistance. In the present study, we evaluated the relationship between carotid haemodynamics and the proinflammatory cytokines, IL-6 and hs-CRP. In all, 41 patients with essential hypertension participated. The intima-media thickness (IMT), peak systolic velocity (pVs), peak diastolic velocity (pVd) and mean velocity (mV) in the common carotid artery were measured using ultrasound Doppler flow methods, and PI [(pVsÀpVd)/mV] and RI [(pVsÀpVd)/pVs] were calculated. Serum IL-6 and hs-CRP concentrations were measured by an enzyme-linked immunosorbent assay. IMT was positively correlated with age and pulse pressure. Both PI and RI were positively correlated with pulse pressure, IL-6 and hs-CRP. A multiple regression analysis revealed that PI and RI were independently associated with hs-CRP. These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients.

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Section: Discussionmentioning

confidence: 88%

Association between carotid haemodynamics and inflammation in patients with essential hypertension

et al. 2005

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“…Chae et al (18) suggested that HBP increases the risk of atherosclerosis by promoting inflammatory activation of the arterial wall. Hypertension may result in an increase in vascular oxidative stress and exert a pro-inflammatory influence on the arterial wall (13). However, the clear mechanism by which HBP leads to atherosclerosis remains unclear, and few studies have focused on the significance of elevated hs-CRP in hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, a recent prospective study has shown that elevated hs-CRP levels may predict DM2 development among apparently healthy subjects (11). Also, there are only a few studies that have investigated the relationship between hs-CRP and hypertension, but these studies showed that hypertensive patients had higher hs-CRP levels than normotensive subjects (12,13). Considering the hypothesis that DM2 and HBP may contribute for CVD development and that inflammation may be an important factor for these diseases, the present study aimed to measure plasma hs-CRP levels in subjects with type 2 diabetes mellitus and/or high blood pressure and compare them to normal subjects.…”

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confidence: 99%

High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

Lima

Carvalho

Soares

et al. 2007

Arq Bras Endocrinol Metab

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Type 2 diabetes mellitus (DM2) and high blood pressure (HBP) may contribute to the development of cardiovascular disease, and inflammation may be an important factor in these diseases. In the present study, plasma levels of high-sensitivity C-reactive protein (hs-CRP) were measured in subjects with DM2 and/or HBP and compared to those of normal subjects. Eighty-nine subjects were analyzed for hs-CRP, including 13 normotensive patients with DM2, 17 patients with HBP, 34 hypertensive patients with DM2 (DM2+HBP) and 25 normal subjects. The plasma hs-CRP levels were significantly lower in the controls than in the HBP+DM2 group (p < 0.05). DM2 associated with HBP was also correlated with increased plasma hs-CRP levels (n = 89, r = 0.25, p = 0.0162). Only hypertensive patients with DM2 had higher levels of hs-CRP, a circulating inflammatory marker, than normal subjects. This finding suggests that patients with two associated diseases have a more active inflammatory state.

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“…1,2) Among biomarkers of inflammatory status, C-reactive protein (CRP) is the most widely used predictor of worse clinical outcomes. [3][4][5][6] Cardiac resynchronization therapy (CRT) is a well established treatment for patients with severe heart failure despite optimal medical treatment. Many studies have demonstrated that CRT improves exercise capacity, quality of life, New York Heart Association (NYHA) functional class, mortality in heart failure patients with impaired left ventricular (LV) systolic function, and intraventricular conduction delay.…”

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confidence: 99%

High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

et al. 2012

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SummaryThe purpose of this study was to determine whether high sensitivity C-reactive protein (hsCRP) before cardiac resynchronization therapy (CRT) implantation was able to predict the response to CRT and cardiac deaths in severe heart failure patients. The study population consisted of 65 heart failure patients (46 males, mean age 65.0 ± 11.8 years, NYHA class III/IV) with CRT implantation. Levels of hsCRP and B-type natriuretic peptide (BNP) were measured before CRT implantation. Left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), and left ventricular ejection fraction (LVEF) were assessed by echocardiography at the same time. At 6 months after device implantation follow-up, echocardiography was performed and reverse remodeling was defined as > 15% reduction in LVESV. Of the 61 patients (4 patients died within 6 months), 41 patients (67%) and 20 patients (33%) were classified as responders (group-R) and nonresponders (group-NR), respectively. Cardiac deaths occurred more frequently in group-NR than in group-R (29% versus 5%, P < 0.05). Hs-CRP level was significantly higher in group-NR than in group-R (P < 0.01). Multivariate logistic regression analysis showed an independent relationship between hsCRP and the incidence of nonresponders (odds ratio: 1.499, P = 0.011). Stepwise multivariate Cox proportional hazard analysis identified the hsCRP level as the strongest predictive factor for cardiac death (hazard ratio: 1.337, P = 0.001). Receiver operating characteristic (ROC) analysis revealed hsCRP levels of 3.0 mg/L as the cut-off value for cardiac mortality. The hsCRP level may provide a new insight into CRT implantation for severe heart failure by predicting responses to CRT and cardiac death. (Int Heart J 2012; 53: 306-312)

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Association of High Sensitivity C-Reactive Protein With Coronary Heart Disease Prediction, but not With Carotid Atherosclerosis, in Patients With Hypertension

Cited by 67 publications

References 32 publications

Association between carotid haemodynamics and inflammation in patients with essential hypertension

Association between carotid haemodynamics and inflammation in patients with essential hypertension

High-sensitivity C-reactive protein in subjects with type 2 diabetes mellitus and/or high blood pressure

High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

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