Association of HLA‐DQA1^∗03011‐DQB1^∗0301 haplotype with the development of respiratory scleroma

Abstract

Results established that DQA1*03011-DQB1*0301 haplotype is a strong risk factor for development of RS.

Rhinoscleroma in a 5-year-old Portuguese Child

“…6 Our patient's genetic study was negative. Impaired cellular immunity with low CD4+ lymphocyte count and high CD8+ lymphocyte count and with decreased CD4/CD8 ratio within the lesion, possibly inducing a diminished or altered T-cell response, may be responsible for an increased host susceptibility to the development of rhinoscleroma.…”

Social geography of Rhinoscleroma and qualitatively and quantitatively abnormal cell-mediated immunity

“…In a more recent study, Sánchez-Marín et al compared nine RS patients and 163 healthy controls and demonstrated a significant association between DQB1*0301 and susceptibility to RS. The authors proposed that DQA1*03011-DQB1* 0301 haplotype may be a strong risk factor for development of RS; in their study individuals carrying DQ3 had 58% more risk to develop RS than those with another haplotype (Sanchez-Marin et al, 2007).…”

The Molecular Genetics of Inflammatory, Autoimmune, and Infectious Diseases of the Sinonasal Tract: A Review

“…66 The HLA-DQ3 allele has been seen in a family with rhinoscleromatosis, and more recent investigations have shown the HLA haplotype HLA-DQA1*30101-DQB1*0301 in almost 50% of patients with the disease. 93 It is believed that this HLA haplotype can bind to K rhinoscleromatis and as a result enables the production of the inflammatory reaction, which causes the clinical and pathologic manifestations. 93…”

“…93 It is believed that this HLA haplotype can bind to K rhinoscleromatis and as a result enables the production of the inflammatory reaction, which causes the clinical and pathologic manifestations. 93…”