Association of HLA-DR4 (DRB1*0404) With Human Papillomavirus Infection in Patients With Focal Epithelial Hyperplasia

García-Corona, Cristina; Vega‐Memije, Elisa; Mosqueda‐Taylor, Adalberto; Yamamoto-Furusho, Jesús K.; Carreón, Alma Angélica Rodríguez; Ruiz-Morales, Jorge A.; Salgado, N. Martin; Granados, Julio

doi:10.1001/archderm.140.10.1227

Cited by 62 publications

(65 citation statements)

References 23 publications

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“…), probablement responsable d'un déficit immunitaire primaire, mineur, non identifié, semble favoriser le développement de l'affection le plus souvent dans l'enfance. Une hypothèse émise par García-Corona et al [17] suggère que le locus HLA-DR joue un rôle dans la physiopathologie de l'HEF en sélectionnant les individus génétiquement prédisposés, particulièrement ceux qui sont homozygotes pour HLA-DR4 et son allèle 0404.…”

Section: Discussionunclassified

Hyperplasie épithéliale focale et syndrome de Waldmann. Présentation d’un cas

Hage

Najm

Lombardi

et al. 2009

Med Buccale Chir Buccale

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Section: Discussionunclassified

Hyperplasie épithéliale focale et syndrome de Waldmann. Présentation d’un cas

Hage

Najm

Lombardi

et al. 2009

Med Buccale Chir Buccale

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“…In 1993, Premoli-De-Percoco found that members of six generations of a Venezuelan family had been diagnosed with MEH and concluded that the disease has a genetic basis, noting that all generations were born in a small village with a very strong American Indian genetic component (37). In 2004, García-Corona et al assessed the effect of genetics by studying the association of HLA-DR4 alleles (DRB1 * 0404) with HPV infection, yielding results in support of the genetic basis of MEH (4).…”

Section: Human Papillomavirus and Other Etiological Factorsmentioning

confidence: 99%

“…Multifocal epithelial hyperplasia (MEH) is an uncommon disease characterized by the proliferation on the oral mucosa of multiple papulonodular lesions, which are smooth, soft on palpation and generally asymptomatic (1)(2)(3)(4)(5). It has mainly been observed among isolated groups of native Indians in North, Central and South America and in other very small population groups in Europe and Africa (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Multifocal epithelial hyperplasia: A potentially precancerous disease? (Review)

Bascones-Martínez¹,

Cok²,

Bascones-Ilundáin³

et al. 2011

Oncology Letters

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Abstract. Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Although the majority of reported cases have been among American Indians and Eskimos, it has been described in multiple ethnic groups in various geographical locations. The objective of this review was to report on the clinical characteristics and epidemiology of MEH and its possible correlation with oral cancer. It is based on a search of articles in international journals published prior to April 2011, using the PubMed database and selecting articles related to the epidemiology and clinical characteristics of MEH. The review revealed a higher number of cases in individuals of American Indian origin and a predilection of the disease for the female gender and for patients between the 1st and 2nd decades of life. The most frequent lesion site was the lower lip. The disease has been associated with socio-economic and genetic factors, among others. No cases of malignant transformation have been reported.

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“…The most common associated subtypes are 13, 32, although Cross reaction with other subtypes (6,11,16,8,55) has also been reported (1,3,7). Certain HLA subtypes have been related to this disease (9). Immunohistochemical analysis for cytokeratines has been performed on MEH lesions but the results were nonspecific like every other acanthotic epithelial lesion in oral cavity (2).…”

Section: Introductionmentioning

confidence: 99%

Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Mosannen-Mozaffari¹,

Falaki²,

Amirchaghmaghi³

et al. 2010

Med Oral

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Objectives: Multifocal epithelial hyperplasia (MEH) is benign, asymptomatic oral disease with viral etiology. The frequency of this disease varies widely from one geographic region to another, and can vary, from 0.002 to 35% depending on the population studied. Study design: Here we report the clinicopathological features of twelve cases of MEH referred to Oral Medicine Department of Mashhad Dental School for the first time in Iran. Records of patients with the diagnosis of MEH in our department during 7 years were analyzed and data were extracted. Results: Most of the patients were younger than 20-year-old (66%), and females were predominantly affected (7:12). The mean age of onset was 12.72±10.14 years and the mean duration was 52.54 ± 78.51 months. Patients had multiple, well circumscribed, soft, non tender, flattened papules, with a color similar to the adjacent mucosa, in different areas of the oral cavity but the most affected site was buccal mucosa. Familial history of such lesions was negative in all patients. Only three cases showed spontaneous regression. Conclusion: In spite of rare nature of this disease in Asia, it seems that it is not the case in Khorasan Province, southeast Iran.

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Association of HLA-DR4 (DRB1*0404) With Human Papillomavirus Infection in Patients With Focal Epithelial Hyperplasia

Cited by 62 publications

References 23 publications

Hyperplasie épithéliale focale et syndrome de Waldmann. Présentation d’un cas

Hyperplasie épithéliale focale et syndrome de Waldmann. Présentation d’un cas

Multifocal epithelial hyperplasia: A potentially precancerous disease? (Review)

Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

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