2016
DOI: 10.1001/jamaneurol.2016.0980
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Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis

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Cited by 78 publications
(79 citation statements)
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References 33 publications
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“…Individuals who are HLA-DRB1*15:01 homozygotes carry a high-risk genotype with ORs exceeding 7.0, compared to a range between 3.5 and 5.0 for heterozygotes HLA-DRB1*15:01 / X . In addition to risk, HLA-DRB1*15:01 has been associated with phenotypic markers of disease severity [89]. A decade long effort of genomic screens provided statistical evidence for over 30 independent allelic and genetic associations within the extended MHC region.…”
Section: Mhc Boxmentioning
confidence: 99%
“…Individuals who are HLA-DRB1*15:01 homozygotes carry a high-risk genotype with ORs exceeding 7.0, compared to a range between 3.5 and 5.0 for heterozygotes HLA-DRB1*15:01 / X . In addition to risk, HLA-DRB1*15:01 has been associated with phenotypic markers of disease severity [89]. A decade long effort of genomic screens provided statistical evidence for over 30 independent allelic and genetic associations within the extended MHC region.…”
Section: Mhc Boxmentioning
confidence: 99%
“…Given previous reports of greater risk effects of DR15 in female patients with multiple sclerosis (MS) [44] and the stronger effect of APOE ɛ4 in females [45], we assessed whether men versus women showed similar or different HLA haplotype associations with AD risk. When split by sex, two of the three most significant five-allele haplotypes from the combined sex analysis were significant in an individual sex.…”
Section: Resultsmentioning
confidence: 99%
“…We calculated the cumulative HLA genetic burden (HLAGB) resulting from carrying different alleles in different HLA genes in 652 MS patients who had comprehensive phenotypic information and 455 controls of European descent. As suggested by previous studies, we found that higher HLAGB scores are associated with younger age at onset and the atrophy of subcortical gray matter fraction in women with RR-MS. Conversely, HLA-B*44:02 showed a nominally protective effect for subcortical gray matter atrophy (37).…”
Section: Genotype-phenotype Correlations In Msmentioning
confidence: 96%