Association of HLA subtype DRB1<sup>*</sup>0407 in Colombian patients with actinic prurigo

Alfonso, Suarez; Valbuena, Martha Cecilia; Rey, Maritza; Quintana, Luisa de Porras

doi:10.1111/j.1600-0781.2006.00205.x

Cited by 28 publications

(16 citation statements)

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“…These findings are concordant with studies in Latin America 5,6 and Western Europe 7–9 regarding the role of class II major histocompatibility complex (MHC) alleles in the pathophysiology of AP; in addition, we propose a class I and class II MHC haplotype and suggest that it would include other genes located within the class I and class II MHC regions, such as tumour necrosis factor and heat shock proteins. The relevant alleles involved in both susceptibility and protection regarding the development of AP (HLA‐DRB1*0407, HLA‐DRB1*1406, HLA‐B39 and HLA‐DRB1*0802) are particularly frequent in Amerindians from Mexico, 10 strongly suggesting that the autochthonous genetic background in the mestizo population is at play.…”

Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientssupporting

confidence: 89%

“…It has a 2 : 1 female/male ratio. It has been described in native North Americans, 3 the mestizo population and some Indian groups from Mexico, 2,4 Guatemala, Honduras, Colombia, 5 Bolivia and Peru, as well as in some populations from North Western Europe (England, 6 Ireland 7 and Scotland 8 ).…”

Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientsmentioning

confidence: 99%

“…Multiple studies report association of HLA genes with the susceptibility to develop AP 4–9 . Increased frequencies of HLA‐A28, HLA‐B39 and HLA‐DR4 have been shown in Mexican patients with AP, HLA‐DR4 being present in 92·8% of patients and HLA‐DRB1*0407 in 80·7% 5 . Nevertheless, it is not known if Mexican patients who do not present the HLA‐DRB1*0407 allele show clinical manifestations of AP.…”

Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientsmentioning

confidence: 99%

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Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

et al. 2007

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4 Dalle S, Balme B, Sebban C et al. Schnitzler syndrome associated with systemic marginal zone B-cell lymphoma. Br J Dermatol 2006; 155:827-9. 5 Baty V, Hoen B, Hudziak H et al. Schnitzler's syndrome: two case reports and review of the literature. Mayo Clin Proc 1995; 70:570-2. 6 Pascual-López M, Hernández-Núñez A, Sánchez-Pérez J et al. Schnitzler's syndrome with monoclonal IgG kappa gammopathy: good response to cyclosporin. J Eur Acad Dermatol Venereol 2002; 16:267-70. 7 Modiano P, Barbaud A, Laveine E et al. Efficacité de la PUVA thérapie dans un syndrome de Schnitzler. Nouv Dermatol 1995; 14:362-3. 8 Worm M, Kolde G. Schnitzler's syndrome: successful treatment of two patients using thalidomide. Br J Dermatol 2003; 148:601-2. 9 Peterlana D, Puccetti A, Tinazzi E et al. Schnitzler's syndrome treated successfully with intravenous pulse cyclophosphamide. Scand J Rheumatol 2005; 34:328-30.

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Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientssupporting

confidence: 89%

Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientsmentioning

confidence: 99%

Section: Gene Frequencies Of the Hla‐dr4 Allele Subtypes In Patientsmentioning

confidence: 99%

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Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

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“…1 It is believed that the disease is caused by a late hypersensitivity reaction against autoantigens induced by ultraviolet radiation in genetically predisposed individuals. 2 However, these chromophores have not been identified. [1][2][3] Ultraviolet A and B rays are involved in the process.…”

Section: Commentariesmentioning

confidence: 99%

“…2 However, these chromophores have not been identified. [1][2][3] Ultraviolet A and B rays are involved in the process. 3 The disease was described among NorthAmerican Indians and Central and South America mestizos, with very few reports in the Asian and Caucasian population.…”

Section: Commentariesmentioning

confidence: 99%

Caso para diagnóstico

Daldon

Pascini

Correa³

2010

An. Bras. Dermatol.

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HISTORY OF THE DISEASEA thirteen-year-old black boy, native of Sao Paulo, complained of recurring pruritic lesions on his forearms associated with edema of the lower lip, photophobia, and red eyes that had developed two years before. Physical examination revealed conjunctival enanthema associated with pterygium ( Figure 1). The lower lip was everted, swollen, exulcerated with vegetant lesions all over its extension (Figure 2). Erythematous, scaly, crusted lesions in the nose ( Figure 1); excoriated papules and nodules in the forearms were observed in association with residual hyperchromic maculae ( Figure 3). The patient presented low cognitive development without previous diseases. He denied similar cases of the disease in his family. An Bras Dermatol. 2010;85(5):733-5.Skin biopsy of the lower lip showed acanthosis and spongiosis with dermal perivascular mononuclear cell infiltration composed by lymphocytes, plasma cells, and eosinophils (Figure 4). Eye examination revealed enanthema, Trantas dots, and pterygium. After three months of thalidomide use (100mg/day), remission of lesions was observed, including that of cheilitis. The patient suspended the medication and symptoms recrudesced. Treatment with thalidomide 100mg/day for six months was reestablished with rapid improvement; the dose was then reduced to 50mg/day and lesions were controlled for two more years. The patient's low cognitive development prevented the progressive reduction of medication.

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Dermatoses of the Oral Cavity and Lips

Scully¹

2016

Rook's Textbook of Dermatology, Ninth Edition

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Oral and labial lesions are usually the result of local disease but may be the early signs of systemic disease, including dermatological disorders, and in some instances may cause the main symptoms. This chapter mainly discusses disorders of the periodontal and mucosal tissues that may be related to skin disease and that may present at a dermatology clinic. It should be borne in mind that the professionals most competent in diagnosing and treating oral diseases are those with formal dental training and who are therefore in a position to understand the full complexities of the region. This chapter is divided into a brief discussion of the biology of the mouth, an overview of the more common signs and symptoms affecting specific oral tissues, discussion of the disorders of the oral mucosa of most relevance to dermatology and a tabulated review of oral manifestations of systemic diseases. Only the more classic oral lesions are illustrated. For reasons of space restrictions, diseases affecting the teeth, salivary glands, jaws or temporomandibular joints are not discussed in any depth.

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Association of HLA subtype DRB1^*0407 in Colombian patients with actinic prurigo

Cited by 28 publications

References 28 publications

Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

Caso para diagnóstico

Dermatoses of the Oral Cavity and Lips

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Association of HLA subtype DRB1*0407 in Colombian patients with actinic prurigo

Cited by 28 publications

References 28 publications

Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

Class I and class II major histocompatibility complex genes in Mexican patients with actinic prurigo

Caso para diagnóstico

Dermatoses of the Oral Cavity and Lips

Contact Info

Product

Resources

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Association of HLA subtype DRB1^*0407 in Colombian patients with actinic prurigo