Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer

Sato, Masaru; Miura, Kou; Kageyama, Chihiro; Sakae, Hiroyuki; Obayashi, Yuka; Kawahara, Yoshiro; Matsushita, Osamu; Yokota, Kenji; Okada, Hiroyuki

doi:10.1186/s13027-019-0221-1

Cited by 9 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Helicobacter pylori, which is not only the leading risk factor for gastric cancer but also a high risk of recurrence, colonizes the gastric mucosa and induces persistent chronic gastric inflammation. [21,22] Patients with a genotype of high IgG1 level will have a higher risk of recurrence than patients with other genotypes. Our study demonstrated that SSF3(Helicobacter pylori) is the third leading feature for the recurrence of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

A Cost-Effective Predicting Model for Recurrent Gastric Cancer by Clinical Features

Chen,

Ting,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

This study was to identify clinical cancer biomarkers for recurrent gastric cancer survivors using artificial intel-ligence. From a hospital-based cancer registry database in Taiwan, the datasets of the incidence of recurrence and clinical risk features were included in 2476 gastric cancer survivors. We benchmarked Random forest with MLP, C4.5, AdaBoost, and Bagging algorithms on metrics and leveraged synthetic minority oversampling technique (SMOTE) for imbalanced dataset issues, cost-sensitive learning for risk assessment, and SHapley Additive ex-Planations (SHAP) for feature importance analysis in this study. Our proposed Random forest outperformed the other models with an accuracy of 87.9%, a recall rate of 90.5%, an accuracy rate of 86% and F1 of 88.2% on re-current category by a 10-fold cross-validation in a balanced dataset. We identified clinical features of recurrent gastric cancer, which are the top five features, stage, number of regional lymph node involvement, Helicobacter pylori, BMI(body mass index), and gender, which significantly affect the prediction model's output, are worth paying attention to in the following causal effect analysis. Using an artificial intelligence model, the risk factors for recurrent gastric cancer could be identified and cost-effectively ranked according to their feature importance. In addition, they should be crucial clinical features to provide physicians with the knowledge to screen high-risk patients in gastric cancer survivors as well.

show abstract

Section: Discussionmentioning

confidence: 99%

A Cost-Effective Predicting Model for Recurrent Gastric Cancer by Clinical Features

Chen,

Ting,

Lee

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The incidence of gastric cancer is associated with geographical factors, strain diversity, and host immunological responses. The highest incidence of gastric cancer is reported in East Asian countries [16]. In 2017, there were 1.22 million new cases of gastric cancer with 865.000 deaths and 19.1 million disability-adjusted life-years.…”

Section: Epidemiology and Burden Of H Pylori Infectionmentioning

confidence: 99%

“…Defects in gene coding IL-1 and TNF are associated with decreased cytokines production and Immunology of Helicobacter pylori Infection DOI: http://dx.doi.org/10.5772/intechopen.104592 increased risk for gastric cancer [7]. Single nucleotide polymorphism in gene coding IL-10 which resulted in increased IL-10 will promote Th2 activity and resulted in prolonged H. pylori infection and an elevated risk for recurrent gastric cancer [16]. The presence of H. pylori in the macrophages alters the expression of miRNA.…”

Section: Mechanism Of Immune Evasion Of H Pylorimentioning

confidence: 99%

Immunology of Helicobacter pylori Infection

Darmadi¹,

Ruslie²

2022

Immunology of the GI Tract - Recent Advances

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is the most common infecting microorganism in humans. H. pylori had coexisted with humans for 30,000 years ago and developed extensive survival adaptations. The infection is both active and chronic and leads to several disorders from chronic gastritis to gastric adenocarcinoma. The prevalence of H. pylori infection is still high in developing countries. The burden of disease due to infection is also heavy. The persistence of infection is the basis of diseases. H. infection activates innate and adaptive immune responses but the immune response fails to eradicate the infection. H. pylori is able to evade both innate and adaptive immune responses. It can neutralize gastric acid, elicit autoimmunity toward parietal cells, prevent phagocytosis, induce apoptosis of immune cells, inhibit lymphocyte proliferation, disrupt imbalance between humoral and cellular adaptive immune responses, promote regulatory T cell activity, and trigger genetic rearrangement. Host factor is involved in the incidence of H. pylori infection and its complications. Reinfection after eradication is common. Multiple drug resistance has also emerged. Vaccination is a promising management approach to eradicate H. pylori and prevent diseases it caused. The development of the vaccine itself needs to consider the immune escape mechanism of H. pylori.

show abstract

“…Genetic constituents also assumed as a significant cause in gastric carcinogenesis; might be due to alteration in the expression of normal genes, resulted in phenotypic malignancy [17,18]. Hence, the time to time studies on H. pylori in relation to genetic and environmental risk factors are required to uncoil the complexity of this disease.…”

Section: Pathogenesis Of Gastric Cancermentioning

confidence: 99%

Microbial Etiopathogenesis of Gastric Malignancy

Singh¹,

Gaur²,

Singh³

2022

Act Scie Micro

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common disease and fifth most common cancer among male and seventh most common cancer among female in India. It is the most frequent causes of majority of deaths among non-communicable diseases in the world.The incidence of GC is higher in developed Asian countries like Republic of Korea, China, India and Japan. This review summarizes the newer concepts of microbial etiopathogenesis and molecular or recent diagnostic tools of GC and the new important recommendations for the management of patient with GC.The etiological factors and pathogenesis of GC are not yet fully understood but it is affected by several other factors like; strain diversity, genetics, environmental, immunological response of host, exposure to N-nitroso compounds from diet or smoking, alcohol, low socioeconomic status, BMI, age, previous gastric surgery and geographical distribution. To understand the pathogenesis of GC, several researchers mentioned the incidence, etiology, diagnostic tools and the different therapeutic options have also undergone important changes in recent years. Helicobacter pylori is a well recognized risk factor, which can modulate the acidity of the stomach to alter the gastric microbiome, causing H. pylori-associated diseases. Moreover, there is increasing evidence that bacteria other than H. pylori and their metabolites also contribute to gastric carcinogenesis. Therefore, the development and progression of GC can lead to improvements in prevention, diagnosis, and treatment. In this review, we discuss the carcinogenic effects of H. pylori and non-H. pylori microorganism in GC, as well as the potential therapeutic role for GC.

show abstract

Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer

Cited by 9 publications

References 22 publications

A Cost-Effective Predicting Model for Recurrent Gastric Cancer by Clinical Features

A Cost-Effective Predicting Model for Recurrent Gastric Cancer by Clinical Features

Immunology of Helicobacter pylori Infection

Microbial Etiopathogenesis of Gastric Malignancy

Contact Info

Product

Resources

About