Association of HOTAIR (rs920778 and rs1899663) and NME1 (rs16949649 and rs2302254) gene polymorphisms with breast cancer risk in India

Rajagopal, Taruna; Seshachalam, Arun; Akshaya, R.L.; Rathnam, Krishnakumar; Talluri, Srikanth; Arunachalam, J.; Dunna, Nageswara Rao

doi:10.1016/j.gene.2020.145033

Cited by 15 publications

(15 citation statements)

References 45 publications

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“…In Hassanzarei’s study, they found that the rs920778 SNP was only significantly associated with ER status ( 25 ). In Rajagopal’s study, they found that the rs920778 variant (AG + GG genotype) increased BC risk in premenopausal women (OR = 5.86, 95% CI = 3.87–8.88, P < 0.0001) ( 24 ). However, we did not find any relationship between the rs920778 SNP and any clinicopathological features.…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population

Kou

Chen

et al. 2021

Front. Oncol.

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BackgroundThe long noncoding RNA HOX transcript antisense RNA (HOTAIR) is highly expressed in breast cancer (BC) tissues and is associated with the recurrence and metastasis of BC. Until now, the results of studies on associations between several functional single nucleotide polymorphisms(SNPs) (rs920778, rs1899663, and rs4759314) in HOTAIR with BC susceptibility carried out in different regions of China are still inconsistent. There is no study on correlation between HOTAIR SNPs and prognosis of Chinese population. Therefore, we investigated the relationship between HOTAIR SNPs and susceptibility to and prognosis of BC.MethodWe conducted a population-based case-control study involving 828 BC cases and 905 healthy controls. Peripheral blood DNA was used for genotyping. The association between HOTAIR genotypes and BC risk were estimated by odds ratios (ORs) computed using the binary logistic regression model. The relationships between HOTAIR SNPs and clinicopathological features were tested by Pearson’s chi-square test or Fisher’s exact test. Survival was analyzed using the Kaplan-Meier method.ResultsThe functional rs920778 genetic variant increased BC risk in the codominant model. Individuals with the rs920778 GG genotype had an OR of 2.426 (95% confidence interval [CI] = 1.491–3.947, P < 0.001) for developing BC compared to individuals with the AA genotype. Individuals with the AG genotype had an OR of 1.296 (95% CI = 1.040–1.614, P = 0.021) for developing BC compared to individuals with the AA genotype. Individuals with the rs4759314 GA genotype had a lower BC risk than individuals with the rs4759314 AA/GG genotype (OR = 0.566, 95% CI = 0.398–0.803, P = 0.001). The rs1899663 genotype had no correlation with BC susceptibility. Haplotypes composed of rs920778–rs1899663 and rs920778–rs1899663–rs4759314 could increase BC risk (all P < 0.001). There were no statistically significant associations between HOTAIR SNPs and clinicopathological characteristics. The rs920778 GG/AG genotypes were associated with worse disease-free survival (DFS) (p = 0.012), and the rs4759314 GA genotype was associated with worse DFS and overall survival (OS) (p = 0.011).ConclusionHOTAIR SNPs(rs920778 and rs4759314) are significantly related to BC susceptibility and prognosis in the northeastern Chinese population, indicating the significance in the occurrence and development of BC.

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Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population

Kou

Chen

et al. 2021

Front. Oncol.

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“…Studies have suggested that SNPs of HOTAIR may be associated with an increased risk of various cancers. 15 , 16 In the studies conducted in the Turkish population, HOTAIR rs12826786, rs1899663, and rs920778 polymorphisms were investigated in gastric, lung, and breast cancer. HOTAIR polymorphisms were not associated with gastric cancer, but it was suggested that they could play an important role in genetic susceptibility to lung and breast cancer development and invasion.…”

Section: Discussionmentioning

confidence: 99%

Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study

Kaya¹,

Peker²,

Tuğrul³

et al. 2022

Turk J Gastroenterol

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Background: Long noncoding RNAs increase the overexpression of oncogenes. Cancer development and metastasis of cancer may occur as a result of overexpression of oncogenes. Polymorphisms in the genes (such as HOTAIR , etc.) in which long noncoding RNAs are synthesized affect the expression of these genes. Therefore, these polymorphisms may play a role in cancer development and cancer metastasis. The present study aimed to evaluate the association between HOTAIR gene rs1899663 G>T polymorphism with colorectal cancer. Methods: The current study examined the HOTAIR gene rs1899663 G>T polymorphism in 100 patients with colorectal cancer and 93 healthy persons by a real-time polymerase chain reaction. Results: The G and T allele frequencies of the HOTAIR rs1899663 polymorphism were significantly different between the case and control groups ( P = .01). The persons carrying the G allele had a protective effect against colorectal cancer, while individuals carrying the T allele were predisposed to colorectal cancer ( P = .001). Four of 5 colorectal cancer recurrence patients had the TT genotype ( P = .02). Conclusion: This research is the first to demonstrate the relationship between colorectal cancer and the HOTAIR gene rs1899663 polymorphism in the Turkish population, which is a Caucasian population. Our results suggest that the rs1899663 G allele has a protective role for colorectal cancer in the Turkish population. However, it would be appropriate to conduct this research with a larger sample to confirm this result in the Turkish population.

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“…However, a protective effect was observed in Chinese, although limited to a subgroup (menopause age: ≤50) [125]. Because of human races diversity, rs1899663 T allele in Indian is a dangerous factor, while it is a protective factor in Iranian and Chinese [123][124][125]. Similarly, rs920778 T>C is associated with higher risk of breast cancer in Turkish, Indian and Iranian, but Yan et al demonstrated T allele is a risk factor in Chinese [122][123][124][125].…”

Section: Hotair Single Nucleotide Polymorphisms (Snps) and The Susceptibility Of Breast Cancermentioning

confidence: 99%

“…SNPs influence the risk of developing diseases or altering pathological parameters, which may vary among human races. Several SNPs of HOTAIR, including rs12826786, rs920778, rs1899663, and rs4759314 (Table 2), have determined that they are linked to breast cancer susceptibility and other clinical values [121][122][123][124][125]. For rs12826786, individuals carrying T allele have more elevated risk of developing breast cancer than C allele carriers [121,124].…”

Section: Hotair Single Nucleotide Polymorphisms (Snps) and The Susceptibility Of Breast Cancermentioning

confidence: 99%

“…Because of human races diversity, rs1899663 T allele in Indian is a dangerous factor, while it is a protective factor in Iranian and Chinese [123][124][125]. Similarly, rs920778 T>C is associated with higher risk of breast cancer in Turkish, Indian and Iranian, but Yan et al demonstrated T allele is a risk factor in Chinese [122][123][124][125]. Especially in Turkish, Bayram et al revealed rs12826786 and rs920778 are associated with worse clinicopathological parameters, including larger tumor size, advanced stage, poor grade, and distant metastasis [121,122].…”

Section: Hotair Single Nucleotide Polymorphisms (Snps) and The Susceptibility Of Breast Cancermentioning

confidence: 99%

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Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

Shi

Huang

Kong

et al. 2021

Life

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Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack. Accumulating evidence indicates HOX transcript antisense intergenic RNA (HOTAIR) is dysregulated in cancers and has emerged as a novel hotspot in the field. In breast cancer, aberrant HOTAIR expression is responsible for advanced tumor progression by regulating multifarious signaling pathways. Besides, HOTAIR may act as competitive endogenous RNA to bind to several microRNAs and suppress their expressions, which can subsequently upregulate the levels of targeted downstream messenger RNAs, thereby leading to further cancer progression. In addition, HOTAIR works as a promising biomarker and predictor for breast cancer patients’ diagnosis or outcome prediction. Recently, HOTAIR is potentially considered to be a drug target. Here, we have summarized the induction of HOTAIR in breast cancer and its impacts on cell proliferation, migration, apoptosis, and therapeutic resistance, as well as elucidating the underlying mechanisms. This review aims to provide new insights into investigations between HOTAIR and breast cancer development and inspire new methods for studying the association in depth.

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Association of HOTAIR (rs920778 and rs1899663) and NME1 (rs16949649 and rs2302254) gene polymorphisms with breast cancer risk in India

Cited by 15 publications

References 45 publications

Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population

Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population

Association of HOTAIR rs1899663 G>T Polymorphism with Colorectal Cancer in the Turkish Population: A Case–Control Study

Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

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