Association of Human GSTM1 and GSTT1 Genes Polymorphisms with Prostate Tumors in Population of the South Provinces of Iraq

The aim of the study was frequency analysis of GSTM1, GSTT1, and GSTP1 polymorphisms of glutathione S-transferase in the group of patients with prostate cancer and in a control group of healthy individuals. Genomic DNA was isolated; molecular analysis of glutathione S-transferase M1 and T2 polymorphisms was performed using multiplex PCR and RFLP methods. The products of the PCR reaction were then visualized in agarose gel, and a statistical analysis of the results was performed. No statistically significant differences were found in the frequency of glutathione S-transferase polymorphisms between 66 patients with prostate cancer and the control group (64 healthy volunteers). The GSTM1 gene deletion was found in ca. 47% of patients with prostate cancer and in ca. 55% of the controls. The GSTT1 deletion was found in approximately 17% of patients and 14% of the controls. The distribution of GSTP1 Ile/Ile, Ile/Val, and Val/Val polymorphisms was ca. 51.5%, 39%, and 9% in the group of patients and 61%, 34%, and 5% in the control group, respectively. The results indicate that there is no relationship between glutathione S-transferase polymorphisms and prostate cancer in the study group, which is a novelty when compared with the previous work on the role of these genetic variants in the etiology of cancer.

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Polymorphism of glutathione S-transferase in the population of Polish patients with carcinoma of the prostate

Drozdz-Afelt

Koim-Puchowska

Kłosowski

et al. 2020

Environ Sci Pollut Res

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Association of Human GSTM1 and GSTT1 Genes Polymorphisms with Prostate Tumors in Population of the South Provinces of Iraq

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References 17 publications

Polymorphism of glutathione S-transferase in the population of Polish patients with carcinoma of the prostate

Polymorphism of glutathione S-transferase in the population of Polish patients with carcinoma of the prostate

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