2004
DOI: 10.1590/s0074-02762004000600003
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Association of human leukocyte antigen DQ1 and dengue fever in a white Southern Brazilian population

Abstract: Dengue is an infectious disease of viral etiology transmitted by the mosquitoes

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Cited by 36 publications
(33 citation statements)
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“…While either the I-E or the I-A molecule has been shown to suppress the generation of autoantibodies to different antigens (4,16), these B10.BR mice still generated highly cross-reactive antibody ELISA titers to the human platelets and fibrinogen after live D-2V infections (Figure 3) or immunizations with the purified D-2V NS1 protein (6). The HLA-DR4 molecule, positively selected in the Latin American populations, was associated with DHF resistance (20), while the HLA-DQ1 molecule provided DHF resistance in Brazilian populations (24). During a large DHF epidemic in Cuba, some diseases known to be associated with particular HLA class II haplotypes, such as bronchial asthma, were identified as DHF risk factors (15).…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…While either the I-E or the I-A molecule has been shown to suppress the generation of autoantibodies to different antigens (4,16), these B10.BR mice still generated highly cross-reactive antibody ELISA titers to the human platelets and fibrinogen after live D-2V infections (Figure 3) or immunizations with the purified D-2V NS1 protein (6). The HLA-DR4 molecule, positively selected in the Latin American populations, was associated with DHF resistance (20), while the HLA-DQ1 molecule provided DHF resistance in Brazilian populations (24). During a large DHF epidemic in Cuba, some diseases known to be associated with particular HLA class II haplotypes, such as bronchial asthma, were identified as DHF risk factors (15).…”
Section: Discussionmentioning
confidence: 96%
“…Antibody responses to the purified D-2V NS1 protein were influenced by H-2 class II molecules in mice, but all of these PAbs cross-reacted with human fibrinogen, endothelial cells, and platelets, as was observed with MAb 1G5.4-A1-C3 (6), and human class II molecules (HLAs) were shown to affect resistance or susceptibility to DHF (20,24). In this study, (i) the individual reactions of the four MAbs which defined the LX1 epitope against the NS1 proteins of each dengue virus serotype and a panel of other flaviviruses as described previously (6, 10) were compared; (ii) mouse H-2 class II molecules were tested for their abilities to influence PAb responses to the LX1 and ELK/KLE-type epitopes on the NS1 protein after repeated D-2V infections; (iii) the cross-reactions of the PAbs generated in step ii with human fibrinogen and platelets were tested; (iv) a peptide containing the LX1 and ELK-type epitopes was designed, and its potential as an inexpensive diagnostic reagent was tested; and (v) the immunodominance of the LX1 and ELK-type epitopes was tested by using PAbs generated in mice, rabbits, and human patients with DF and DSS.…”
mentioning
confidence: 89%
“…Human genetic background factors in DHF have not been extensively studied. Few studies suggest HLA association with dengue disease severity (45,52). In this study we noticed that several peptides specific to HLA-A*02 and HLA-A*24 evoked very high IFN-␥ responses.…”
Section: Vol 14 2007 T-cell Responses To Ns Regions Of Dengue Virusmentioning
confidence: 99%
“…About 2.5% of those affected die. 152 Several studies [155][156][157][158][159][160][161][162][163] have been conducted about the role of HLA alleles or non HLA alleles in determining resistance, susceptibility or the severity of dengue viral infection, yet only superficial efforts have been made. Thus, a need for detailed genetic studies in different ethnic groups in different countries on a large number of patients is required.…”
Section: Hla and Dengue Virus Infectionmentioning
confidence: 99%