2006
DOI: 10.1016/j.ijporl.2005.12.007
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Association of human metapneumovirus with acute otitis media

Abstract: SummaryObjective-Human metapneumovirus (hMPV) is a recently described paramyxovirus that has been associated with acute upper and lower respiratory infection (LRI) in infants and children worldwide. We previously observed that one-third of the children with hMPV-associated LRI had been diagnosed with a concomitant acute otitis media (AOM). In the current study, we sought to investigate an association between hMPV and children presenting with AOM as a primary diagnosis.Methods-We used realtime RT-PCR for hMPV t… Show more

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Cited by 41 publications
(28 citation statements)
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“…Of importance, however, is the high rate of AOM as a complication of hMPV infection. Together with similar reports by other investigators (12,13,27), hMPV has a particularly strong ability to predispose a child to AOM. This underscores the clinical similarity between hMPV and respiratory syncytial virus, which is also a major viral cause of AOM in children (28)(29)(30).…”
Section: Discussionsupporting
confidence: 79%
“…Of importance, however, is the high rate of AOM as a complication of hMPV infection. Together with similar reports by other investigators (12,13,27), hMPV has a particularly strong ability to predispose a child to AOM. This underscores the clinical similarity between hMPV and respiratory syncytial virus, which is also a major viral cause of AOM in children (28)(29)(30).…”
Section: Discussionsupporting
confidence: 79%
“…A similar association has been found for hMPV, with this finding complicating a third to one half of cases [48,80]. Moreover, hMPV has been detected in sterile middle ear fluid of children with otitis media, suggesting that hMPV may sometimes play a direct causative role in this disease in the absence of bacterial pathogens [84].…”
Section: Upper Respiratory Tract Infectionssupporting
confidence: 69%
“…These results are especially significant because Strptococcus pneumoniae is now known to be the leading cause of respiratory tract related deaths globally especially among children (Malinoski, 2006). Acute respiratory tract infections are also associated with viral infections (Williams et al, 2006). It is recommended that the plant extracts from this study be subjected to viruses related to respiratory diseases.…”
Section: Resultsmentioning
confidence: 91%