Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Nuzhat, Sharika; Palit, Partha; Mahfuz, Mustafa; Islam, Md Ridwan; Hasan, S. M. Tafsir; Islam, Md. Munirul; Sarker, Shafiqul Alam; Kyle, D. J.; Flannery, Robin L.; Vinjamuri, Anita; Lebrilla, Carlito B.; Ahmed, Tahmeed

doi:10.1038/s41598-022-13296-w

Cited by 6 publications

(9 citation statements)

References 62 publications

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“…According to data from Bangladesh, there is an increased likelihood of severe acute malnutrition for every unit increase in the relative abundance of sialylated HMOs 61 . Fifty-four percent of the infants with severe acute malnutrition and 58% of the infants who were not malnourished were born to women who were secretors.…”

Section: Hmos and Anthropometrymentioning

confidence: 99%

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Functional effects of human milk oligosaccharides (HMOs)

et al. 2023

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Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables, such as secretor status, race, geographic region, environmental conditions, season, maternal diet, and weight, gestational age and mode of delivery. HMOs improve the gastrointestinal barrier and also promote a bifidobacterium-rich gut microbiome, which protects against infection, strengthens the epithelial barrier, and creates immunomodulatory metabolites. HMOs fulfil a variety of physiologic functions including potential support to the immune system, brain development, and cognitive function. Supplementing infant formula with HMOs is safe and promotes a healthy development of the infant revealing benefits for microbiota composition and infection prevention. Because of limited data comparing the effect of non-human oligosaccharides to HMOs, it is not known if HMOs offer an additional clinical benefit over non-human oligosaccharides. Better knowledge of the factors influencing HMO composition and their functions will help to understand their short- and long-term benefits.

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Section: Hmos and Anthropometrymentioning

confidence: 99%

“…Fucosylated or undecorated HMOs were not shown to be significantly linked to severe acute malnutrition. This suggests that human milk with a higher relative abundance of sialylated HMOs might have a detrimental effect on the nutritional health of children under the age of 61 .…”

Section: Hmos and Anthropometrymentioning

confidence: 99%

Functional effects of human milk oligosaccharides (HMOs)

et al. 2023

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“…Two studies focused on the effects of undernutrition on HMO composition and consequently on stunting [47], and severe acute malnutrition (SAM) [53], in Malawi and Bangladeshi children respectively. In these studies, ultrasensitive qTOF-MS was used to conduct robust HMO profiling, yielding 50 and 73 HMOs, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Lower levels of fucosylated and sialylated HMO were linked to stunting in Malawian infants [47]. In contrast, total sialylated HMOs were linked to a higher risk of SAM in Bangladeshi children, whilst there was no evidence of a significant association between SAM and fucosylated or undecorated HMOs [53].…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 summarizes the sociodemographic and HMO data from the 27 studies that were included in this review. The selected studies were conducted in 21 countries: Australia [31,43]; Bangladesh [53]; Brazil [36,50]; China [32,41]; Denmark [54]; Finland [30]; France [48]; Gambia [18]; Germany [39]; Kenya [42]; Malawi [47,51]; Netherlands [44]; Philippines [52]; Singapore [33]; Spain [40]; Sweden [49]; and USA [17,34,35,37,38,45]. In addition, there was one European Union study involving milk samples collected from France, Italy, Norway, Portugal, Romania, Spain and Sweden [46].…”

Section: Study Characteristicsmentioning

confidence: 99%

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The role of maternal secretor status and human milk oligosaccharides on early childhood development: A systematic review and meta-analysis

Mulinge,

Abisi,

Kabahweza

et al. 2023

Preprint

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Breast milk is the gold standard of infant nutrition, delivering nutrients and bioactive molecules as needed to support optimal infant growth and neurodevelopment. Increasing evidence links the human milk oligosaccharides (HMOs) to these early childhood development milestones. In this PRISMA-compliant systematic review and meta-analysis, we summarised evidence on HMOs and infant brain development, physical growth, and cognitive development. In addition, we compared HMO concentrations between secretor and non-secretor mothers. Searches in PubMed, Scopus, and Web of Science yielded 245 articles, 27 of which were included in the systematic review and 12 in the meta-analysis. The meta-analysis revealed a substantial between-study heterogeneity, I2= 97.3%. The pooled effect was 0.21 (95% CI, −0.41 - 0.83), p = 0.484, indicating that secretors had higher HMO concentrations, though this difference was not statistically significant. At one month of age, 2’FL, 3FL, and 3’SL play an important role in brain maturation and thus play a critical role in cognitive development. Secretors secrete higher concentrations of 2’FL and 3’SL, explaining the benefits to infants of secretor mothers. Growth velocity was correlated to fucosylated and sialylated HMO concentrations, with lower concentrations linked to stunting. In conclusion, evidence from the systematically reviewed articles indicates that HMOs are important for a child’s early development, but the extent to which they have an impact is dependent on maternal secretor status.

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Associations between human milk oligosaccharides and infant growth in a Bangladeshi mother–infant cohort

Loutet,

Narimani,

Qamar

et al. 2023

Pediatr Res

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Background We aimed to estimate associations between human milk oligosaccharides (HMOs) and infant growth (length-for-age (LAZ) and weight-for-length (WLZ) z-scores) at 12 months postnatal age. Methods In this secondary analysis of data from a maternal vitamin D trial in Dhaka, Bangladesh (N = 192), absolute concentrations of HMOs were measured in 13 ± 1 week(s) postpartum milk samples, infant anthropometric measurements were obtained soon after birth and at 12 months postpartum, and infant feeding was classified during 6 months postpartum. Associations between individual HMOs or HMO groups and LAZ or WLZ were estimated by multivariable linear regression adjusting for infant feeding pattern, maternal secretor status, and other potential confounders. Results The concentrations of 6’sialyllactose, lacto-N-neotetraose, and the non-fucosylated non-sialylated HMOs were inversely associated with LAZ at 12 months of age, whereas the fucosylated non-sialylated HMO concentration was positively associated with LAZ at 12 months. These associations were robust in analyses restricted to infants who were primarily exclusively/predominantly fed human milk during the first 3 (or 6) months. Conclusions Since HMOs are both positively and negatively associated with postnatal growth, there is a need for randomized trials to estimate the causal benefits and risks of exogenously administered HMOs on infant growth and other health outcomes. Impact 6’sialyllactose, lacto-N-neotetraose, and the non-fucosylated non-sialylated human milk oligosaccharides (HMOs) were inversely associated with length-for-age z-scores (LAZ) at 12 months, whereas the fucosylated non-sialylated HMO concentration was positively associated with LAZ at 12 months among Bangladeshi infants. Associations between individual and grouped HMOs with infant length growth at 12 months were as strong or stronger in analyses restricted to infants who were exclusively or predominantly fed human milk up to 3 (or 6) months. Randomized trials are needed to characterize the effects of specific HMOs on infant growth, particularly in countries where postnatal linear growth faltering is common.

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Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads

Cited by 6 publications

References 62 publications

Functional effects of human milk oligosaccharides (HMOs)

Functional effects of human milk oligosaccharides (HMOs)

The role of maternal secretor status and human milk oligosaccharides on early childhood development: A systematic review and meta-analysis

Associations between human milk oligosaccharides and infant growth in a Bangladeshi mother–infant cohort

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