Association of Human Papilloma Virus in Oral Squamous Cell Carcinoma

Abstract

Background: The percentage of cancers of the tongue and palatine tonsils has continued to increase by 2%–4% among younger men. This increased prevalence of a subsection of oropharyngeal carcinoma can be associated with human papillomavirus (HPV). Among the head-and-neck cancers, a strong association with HPV infection is evident with oropharyngeal cancers, particularly tonsillar and basal tongue cancers. Objectives: Oral carcinoma, with an overall incidence of 16.1 adults per 100,000, is one of the leading malignancies worldwide, presenting a noticeable geographic variation in its distribution. Squamous cell carcinoma (SCC) being the most common of all oral malignancies, the objective of the study is to detect the HPV antigen p16 over-expression in patients with oral SCC using immunohistochemistry (IHC). Materials and Methods: Oral SCC (OSCC) diagnosed formalin-fixed-paraffin embedded blocks were processed for IHC. Results: Out of 50 cases, 3 were deferred due to insufficient tumor sample and 2/47 cases were p16 positive and the site was the lateral border of the tongue. Conclusion: The HPV antigen overexpression in patients with OSCC was investigated to detect the incidence of HPV in SCC of oral cavity. P16 was used as a marker for the detection of OSCC using IHC in HPV-induced OSCC. Positives were detected thus concluding the significance of studying HPV expression during diagnosis.

Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma

“…Therefore, risk score, TIDE, and TMB score can be used jointly to achieve more accurate and higher predictive performance in the future. In the gene mutational differential analysis, we identified the tumor suppressor TP53 gene as the most mutated gene, a finding consistent with recent evidence from genome sequencing analysis [ 35 , 36 ]. Multiple studies have shown that the polymorphism of the TP53 gene can increase the susceptibility to oral cancer and may be one of the risk factors for oral cancer [ 37 , 38 ].…”

Knowledge and Awareness of Human Papillomavirus Vaccination for Oral Cancer Prevention among Dental Practitioners, Students, and Patients at UiTM Faculty of Dentistry, Malaysia

“…Oral cancer remains a significant health concern in Malaysia, despite its low prevalence, owing to the increasing trend of HPV infection as an additional risk factor (Venkatesh et al, 2021;Stull et al, 2020). Despite recent evidence linking HPV to oral cancer, there is still limited awareness of this fact due to the scarcity of studies in Malaysia highlighting the correlation between HPV and oral cancer.…”

“…Over the years, the incidence of tobacco-associated HPV-unrelated HNSCC has declined due to decreased tobacco usage (Jung et al, 2021). However, the current trend reveals an alarming increase in the incidence of HPV-associated oropharyngeal cancers (Venkatesh et al, 2021). This change in trend might be attributed to increasing sexual activity in this modern era, such as oral sex and "French kissing".…”

DNA Damage Response Gene Signature as Potential Treatment Markers for Oral Squamous Cell Carcinoma

“…Next, we evaluated whether the expression of the thirty DDR genes found to be deregulated in OSCC patients was associated with infection by high-risk HPV known to have a role in OSCC pathogenesis [23]. We identified eighteen genes whose expression was significantly modulated by HPV status in OSCC patients in whom this clinical information was available (Supplementary Table S1).…”