Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study

Kelishadi, Roya; Jamshidi, Farkhondeh; Qorbani, Mostafa; Motlagh, Mohammad Esmaeil; Heshmat, Ramin; Ardalan, Gelayol; Hovsepian, Silva

doi:10.1016/j.jpedp.2016.06.014

Cited by 12 publications

(28 citation statements)

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“…In adjusted logistic regression models, hypovitaminosis D significantly increased the odds of MNHO, MNHNO, and MHO, respectively. These findings were in line with the previous studies (26)(27)(28)(29). Hypovitaminosis D showed a slightly stronger association with MNHO than other phenotypes of obesity.…”

Section: Discussionsupporting

confidence: 93%

Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study

et al. 2020

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significantly increased the odds of being MHO (OR: 1.46; 95% CI: 1.07-1.77) and MNHO (OR: 2.89; 1.05-8.31) compared to the healthy group. Likewise, in multivariate model, per each unit (ng/mL) increment in 25-hydroxyvitamin D concentration, the odds of MNHNO and MNHO decreased significantly by 7% (OR: 0.93; 0.91-0.96) and 6% (OR: 0.94; 0.91-0.98) respectively. Conclusion: Our results support the hypothesis that 25-hydroxyvitamin D concentration is associated with metabolic obesity phenotypes. Longitudinal studies are necessary to assess the clinical impacts of this finding.

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Section: Discussionsupporting

confidence: 93%

Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study

et al. 2020

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“…In 2014, in the same population and city, with the same classification criteria, the prevalence of HTW was 20.7% 6 , that is, in five years the incidence was 7.2%. Different prevalences have been reported in the literature, similar values have also been observed considering HTW assessments in different places around the world 26,27 , and in Brazil 2-28 , however, in all of them, the criteria and cutoff points were different.…”

Section: Discussionsupporting

confidence: 74%

Hypertrigliceridemic Waist, Physical Activity and Cardiovascular Risk Factors in Schoolchildren

Guilherme

Santos

Fiorillo

et al. 2020

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32The present study aimed to analyze the prevalence of the Hypertriglyceridemic 33 Waist (HTW) and its rates with levels of physical activity, nutritional status and 34 lipid profile of students from public schools. A sample consisted of 448 35 schoolchildren between 10 and 18 years old, who are assessed by body mass, 36 height, BMI (waist circumference), triglycerides, total cholesterol, HDL-C, LDL-C, 37 non-HDL cholesterol, fasting blood glucose and weekly physical activity time. The 38 survey results showed a high prevalence of the HTW phenotype in schoolchildren 39 (n = 125; 27.9%). The group diagnosed with phenotype has higher body mass, 40 BMI, total cholesterol, LDL-C and non-HDL cholesterol and a lower level of HDL-41 C about the group without a diagnosis of the phenotype. However, for fasting 42 blood glucose measurements and time of physical activity, the groups are no 43 different. An association analysis using logistic regression showed the HTW 44 phenotype associated with sex, nutritional status, and total cholesterol, where 45 boys presented 2.0 (95% CI 1.3 -3.2); obese 6.2 (95% CI 2.7 -17.2) and 46 cholesterol levels above 150 mg / dL 3.5 (95% CI 2.1 -5.7) times more likely to 47 have the phenotype. In this way, the present research showed a high prevalence 48 of HTW in schoolchildren from public schools, with boys, obese and 49 schoolchildren with total cholesterol levels, the individuals most likely to have the 50 phenotype. However, it is worth emphasizing the importance of monitoring these 51 variables throughout the year in all courses, given the period of strong, biological, 52 behavioral and psychological changes, as they can quickly change the values of 53 the analyzed variables. 54 55 Key-Words: motor activity, dyslipidemias, blood glucose. 56 57 58 2000s when Lemieux et al., (2000) 1 investigated the hypothesis that variables 62 considered simple such as waist circumference (WC) and plasma triglyceride 63 levels (TG) fasting could be used as useful tools in the identification of risk factors 64 for the development of cardiovascular diseases. 65 Currently, the HTW phenotype is defined as the joint presence of elevated 66 levels of CC and TG, 2 , and those diagnosed in turn, have a higher chance of 67 having increased blood glucose and systemic arterial hypertension, being more 68 prone to the development of the metabolic syndrome and pathologies classified 69 as risk factors for cardiovascular diseases 2 . 70To prevent the HTW phenotype and the risk factors associated with the 71 phenotype in children and adolescents, regular physical activity is 72 recommended 3 , because, in addition to the preventive characters in these age 73 groups, good levels of physical activity provide greater health benefits, presenting 74 better cardiorespiratory and muscular fitness, bone health and maintenance of 75 adequate body weight 4 . 76Despite the association of HTW with body adiposity 3 and consequently 77 the increased cardiometabolic risk in children and adolescents 5 , few studies have 7...

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“…Non-communicable diseases can originate during childhood and adolescence, and they are currently the leading cause of mortality and morbidity in most populations [ 1 , 2 ]. The current epidemic of overweight and obesity [ 3 , 4 ] fits this description.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of excessive body fat among adolescents of a south Brazilian metropolitan region and State capital, associated risk factors, and consequences

et al. 2018

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BackgroundThe prevalence of overweight/obesity has become a major concern for public health in developing countries. Risk factors need to be well documented so that these countries develop public policies to fight the problem. Thus, the objective of this study is to determine the prevalence of excess fat among adolescents of a South Brazilian State Capital associated with risk factors and their consequences.MethodsThis study was conducted between 2014 and 2016 with adolescents aged 11–18 years. The following body composition measurements were collected: body mass, height, waist circumference, fat mass and bone mineral density (this latter through dual energy X-ray absorptiometry). Biochemical data as glucose, total cholesterol, and triglycerides were also collected. Finally, socioeconomic questionnaires were applied, as well as questionnaires regarding: the education level of guardians, active transportation, time spent with sedentary activities and physical activities. Odds ratios and chi-square test were applied in statistical analysis.ResultsData from 675 adolescents, from which 70% were males, were analyzed. The mean age was 14.7 ± 1.8 years. The prevalence of excess fat was 18.2% in boys and 92.1% in girls. As for sedentary lifestyle and physical inactivity, having one of these factors increased the risk of being overweight by 7.9 times for boys and 3.0 times for girls. In boys, there was a significant association between excess fat and waist circumference (p = 0.000; OR = 13.5; CI = 7.0–25.9), physical activity level (p = 0.000; OR = 4.0; CI = 2.5–6.5), triglycerides (p = 0.019; OR = 2.2; CI = 1.1–4.2) and total cholesterol (p = 0.000; OR = 2.6; CI = 1.6–4.5). In girls, there was an association between having excess fat and an increase in total cholesterol (p = 0.000; OR = 8.0; CI = 2.6–24.4).ConclusionsThe high prevalence of excess fat was greater than what was described by some studies conducted in developed countries. This reality demonstrates the need to implement public policies that can directly promote the reduction of sedentary habits and reinforce the importance of adopting an active lifestyle.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-5216-0) contains supplementary material, which is available to authorized users.

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Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study

Cited by 12 publications

References 25 publications

Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study

Association of Serum 25-Hydroxyvitamin D Level With Metabolic Phenotypes of Obesity in Children and Adolescents: The CASPIAN-V Study

Hypertrigliceridemic Waist, Physical Activity and Cardiovascular Risk Factors in Schoolchildren

Prevalence of excessive body fat among adolescents of a south Brazilian metropolitan region and State capital, associated risk factors, and consequences

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