Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus

Abstract

Type II diabetes mellitus (DM) is the most common endocrine disorder and a leading cause of morbidity and mortality across the world. Long-standing diabetes and a poor glycemic control are the major factors which contribute to the development of various microvascular complications of diabetes. Microvascular changes in kidneys lead to microalbuminuria, which may further lead to end-stage renal disease (ESRD) if left untreated. Elevated serum uric acid level has been recognized as a marker of endothelial dysfunction which contributes to the development of microvascular changes in various organs. The main objective of the present study was to assess the association of serum uric acid and urine microalbumin levels with glycosylated hemoglobin (HbA1c) in type II DM patients. One hundred diagnosed cases of type II DM were enrolled for the study. Blood samples were collected and estimated for fasting blood sugar, serum uric acid, and HbA1c. Also, 24-hour urine samples were collected and analyzed for microalbumin. A positive association (r = 0.203) was observed between HbA1c and serum uric acid. The study also suggested a positive association between glycemic control and microalbuminuria (r = 0.237) in diabetic patients. A strong positive association was also observed between uric acid and urine microalbumin levels (r = 0.338). Findings of the study, therefore, recommend that development of microvascular complications in type II DM patients can be averted by adopting dietary control and healthy lifestyle changes. Strict glycemic control and lowering of serum uric acid levels can be helpful in minimizing the risk of developing nephropathy and its progression toward ESRD. How to cite this article Fiza B, Yogi JP, Choudhary J, Semar A, Sinha M. Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus. J Mahatma Gandhi Univ Med Sci Tech 2017;2(1):1-6.