Association of Hyperuricemia With Critical Coronary Artery Disease

Niazi, Gul Zaman Khan; Zab, Jehan; Adnan, Fahar; Ahmed, Nisar; Akhtar, Ammar; Saleemi, Muhammad Sohail

doi:10.47144/phj.v53i2.1813

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…13 Niazi et al, showed the same results with OR 2.06 and 95% CI 1.22-3.49. 18 In a local cross sectional survey at Punjab Institute of Cardiology, critical lesions were more frequent in hyperuricemic group than in normouricemic group (p value on Gensini score in two groups is 0.006 which showed significant difference). 19 Our study showed the similar results to these national and international studies adding further evidence that hyperuricemia has been linked with the coronary artery disease.…”

Section: Discussionmentioning

confidence: 96%

Association of Hyperuricemia With the Presence and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography

et al. 2021

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Objectives: To determine the association of hyperuricemia with the presence and severity of coronary artery disease in patients undergoing coronary angiography. Methodology: This case control study was carried out in the Department of Cardiology, Chaudhary Pervaiz Elahi Institute of Cardiology, Multan for six months. Total number of 292 patients (146 cases with coronary artery disease and 146 controls with normal coronary arteries) having age 40-60 years of both genders were included in this study. Coronary angiography was performed using standard angiographic techniques. After undergoing coronary angiography, patients with 50% luminal stenosis or more in any one of the coronary arteries were labeled case group. Patients with normal coronaries or less than 50% luminal stenosis in any one of the coronary vessels were taken as control group. Serum uric acid was advised and value was noted along with the basic demographic data and established risk factors of coronary artery disease. Results: Mean age was 50.79±6.08 years. Mean serum uric acid was 7.54±3.60 mg/dl. Hyperuricemia was diagnosed in 94 (64.40%) patients with significant CAD (case group) and in only 59 (40.40%) in control group. The odds ratio was 2.66 (95% CI 1.66 to 7.28) with p-value of <0.001. Triple vessel disease was diagnosed in 66.7% patients with hyperuricemia and in only 33.3% patients without hyperuricemia [OR 4.0 (2.09-7.64), p-value <0.001]. Conclusion: There is a significant association between the presence and severity of coronary artery disease with hyperuricemia.

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Section: Discussionmentioning

confidence: 96%

Association of Hyperuricemia With the Presence and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography

et al. 2021

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Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Bowden

Adair

Richardson³

2022

Front. Med.

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IntroductionHyperuricemia commonly associated with Gout has been proposed as an independent risk factor for Metabolic Syndrome (MetS).ObjectiveThe purpose of the study was to determine if there is a relationship between hyperuricemia and MetS.MethodsAn analysis of cross-sectional data was conducted using the 2013–2018 National Health and Nutrition Examination Survey (NHANES) datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized United States (US) civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens.ResultsPearson’s correlations, chi-square tests, and logistic regression equations were calculated to determine the association between hyperuricemia and MetS. In an unadjusted regression analysis, individuals with hyperuricemia (above 7.0 mg/dL in males and 6.0 mg/dL in females) were 3.19 times more likely to have MetS compared to those with normal uric acid (UA) levels. When controlling for various confounding variables those with hyperuricemia were 1.89 and 1.34 times more likely to have MetS than those with normal UA levels in two additional logistic regression models.ConclusionIn this large cross-sectional study, hyperuricemia was found to be associated with MetS. Additional analyses that controlled for various risk factors previously identified as predictive of MetS still demonstrated hyperuricemia independently associated with MetS. The results of this study suggest a need to understand the metabolic pathways of UA more clearly to further explain the contribution to MetS. Additional research should include prospective clinical trials assessing the effects of UA and the control of UA on MetS and concomitant medical outcomes.

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Association of Hyperuricemia With Critical Coronary Artery Disease

Cited by 2 publications

References 15 publications

Association of Hyperuricemia With the Presence and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography

Association of Hyperuricemia With the Presence and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

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