Association ofACEandMDR1Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome

Abstract

Screening these polymorphisms will pave the way to better understand the molecular mechanisms of the disease, which may be useful in developing targeted therapies for INS patients.

A PRISMA-compliant meta-analysis of MDR1 polymorphisms and idiopathic nephrotic syndrome

“…[14–17,31–35] All of the participants in these studies were children consisting of 928 patients with INS and 879 healthy controls; moreover, steroid resistance data were available for 724 patients comprising 488 patients with SS and 236 patients with SR, which were compared. The subjects in 4 studies were Asian [16,17,34,35] and those from the other 5 were Caucasian. [14,15,31–33] Seven studies reported genotype frequencies between patients with INS and healthy controls, [14–16,31,32,34,35] and 7 studies showed the genotype data of SS and SR groups.…”

“…The subjects in 4 studies were Asian [16,17,34,35] and those from the other 5 were Caucasian. [14,15,31–33] Seven studies reported genotype frequencies between patients with INS and healthy controls, [14–16,31,32,34,35] and 7 studies showed the genotype data of SS and SR groups. [14–17,32,33,35] Haplotype frequencies of both case and control cohorts were described in part in 4 studies.…”

“…[14,15,32,35] SS and SR groups were also compared in 4 studies (details provided in Table 1). [14–16,35] Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping in 6 studies, [14–16,31,34,35] the TaqMan genotyping assay was performed in 1 study, [17] and the 2 remaining studies used real-time PCR. [32,33] Blood samples were collected for genotyping in all studies.…”

“…We tested the controls from all 9 studies for HWE and found that the controls in 1 study were not in HWE for rs1045642 and rs2032582 ( P  < .001). [34] The quality of the included studies for our meta-analysis was assessed by NOS and all studies were either of medium or high quality in terms of selection and exposure. However, we found that comparability was poor in some studies (Table 2).…”

Influence of ABCB1 C3435T and C1236T gene polymorphisms on tumour response to docetaxel-based neo-adjuvant chemotherapy in locally advanced breast cancer patients of South India

“…The genotype frequencies were found to be in Hardy‐Weinberg equilibrium ( χ 2 = 0.330). The allele and genotype frequencies of the study population were compared with that of the healthy population and were found to be similar ( P > 0.05; Table ).…”