Association of <i>ACE</i> and <i>MTHFR</i> genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications

Settin, Ahmad; Elbaz, Rizk; Ismaeel, Azza; Tolba, Wafaa; Allah, Wafaa A

doi:10.1177/1470320313516172

Cited by 35 publications

(23 citation statements)

References 29 publications

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“…Literature on the available previous studies, the two important polymorphisms of MTHFR gene 677 C>T and 1298 A>C genotypes were analyzed with PCR-RFLP technique using Hinf1 and MboII digestion, respectively. 15 The screening of C677T, PCR products was digested with 5U of HinfI at 37 C overnight. The 'C' allele gave 387 bp products, whereas the 'T' allele gave 235 bp and 152 bp fragments.…”

Section: Mthfr Markers and Genotypingmentioning

confidence: 99%

Association between end‐stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms

et al. 2019

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Section: Mthfr Markers and Genotypingmentioning

confidence: 99%

Association between end‐stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms

et al. 2019

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“…Clinically, DR is divided into proliferative DR (PDR), preproliferative DR and nonproliferative DR (NPDR) [5]. Much evidence has suggested that genetic predisposition plays a role in the development and progression of DR [6][7][8]. The genetic etiology of DR was investigated by a candidate gene approach, and the potential candidate genes in DR etiology were implicated [8,9].…”

Section: Introductionmentioning

confidence: 99%

Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Lin¹,

Peng²,

Cao³

et al. 2020

Ophthalmic Res

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Controversial results regarding the associations between aldose reductase (AR) genetic polymorphisms and diabetic retinopathy (DR) have been reported for many years. The present meta-analysis was performed to clarify the effects of the AR gene C(-106)T polymorphism on DR risk. The PubMed, Web of Sciences, Cochrane library, EMBASE, Chinese National Knowledge Infrastructure, and Wan Fang databases were extensively searched in Chinese to select relevant studies with an updated date of April 25, 2018. The Newcastle-Ottawa Scale (NOS) was applied to assess quality. The randomeffects model was applied to calculate the pooled OR and 95% CI. This meta-analysis identified 23 studies with an average score of 7.52 for NOS analysis, including 4,313 DR cases and 5,128 diabetes mellitus (DM) control cases. In the overall analysis, a significant association between the AR gene C(-106)T polymorphism and DR susceptibility was found. In subgroups stratified by DM type and ethnicity, significantly increased risks for DR were found in DM type 1, East Asian populations, and Middle Eastern populations. Compared with DR control cases, the following associations were found: T vs. C: OR 0.91, 95% CI 0.85-0.97, I 2 = 72.9%; CT + TT vs. CC: OR 0.75, 95% CI 0.68-0.81, I 2 = 86.7%; and CT vs. CC: OR 0.86, 95% CI 0.78-0.94, I 2 = 70.5%. The results of this meta-analysis showed a significant association between the AR gene C(-106)T polymorphism and susceptibility to DR in DM patients. DM patients with allele T and CT+TT genotype of the AR gene may have a lower risk of DR.

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“…Numbers of molecular epidemiological studies have been performed to examine the relationship between the ACE I/D polymorphism and DR [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55], but the results remain inconclusive. Although several meta-analyses have been published [56,57], they still did not reach a consistent conclusion.…”

Section: Introductionmentioning

confidence: 99%

Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects

Luo

Shi²,

Wang

et al. 2016

IJERPH

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Aims-to address the inconclusive findings of the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods-we conducted a meta-analysis on 4252 DR cases and 5916 controls from 40 published studies by searching electronic databases and reference lists of relevant articles. A random-effects or fixed-effects model was used to estimate the overall and stratification effect sizes on ACE I/D polymorphism on the risk of DR. Results-we found a significant association between the ACE I/D polymorphism and the risk of DR for all genetic model (ID vs. II: OR = 1.14, 95% CI: 1.00-1.30; DD vs. II: OR = 1.38, 95% CI: 1.11-1.71; Allele contrast: OR = 1.17, 95% CI: 1.05-1.30; recessive model: OR = 1.24, 95% CI: 1.02-1.51 and dominant model: OR = 1.21, 95% CI: 1.06-1.38, respectively). In stratified analysis by ethnicity and DM type, we further found that the Asian group with T2DM showed a significant association for all genetic models (ID vs. II: OR = 1.14, 95% CI: 1.01-1.30; DD vs. II: OR = 1.54, 95% CI: 1.14-2.08; Allele contrast: OR = 1.26, 95% CI: 1.09-1.47; recessive model: OR = 1.42, 95% CI: 1.07-1.88 and dominant model: OR = 1.26, 95% CI: 1.07-1.49, respectively). Conclusion-our study suggested that the ACE I/D polymorphism may contribute to DR development, especially in the Asian group with type 2 diabetes mellitus (T2DM). Prospective and more genome-wide association studies (GWAS) are needed to clarify the real role of the ACE gene in determining susceptibility to DR.

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Association of ACE and MTHFR genetic polymorphisms with type 2 diabetes mellitus: Susceptibility and complications

Abstract: The MTHFR 677 TT genotype was associated with T2DM susceptibility and complications (DR, DPN and IHD). The MTHFR 1298 CC, AC and ACE DD genotypes were associated with DR and DPN.

Cited by 35 publications

References 29 publications

Association between end‐stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms

Association between end‐stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms

Association between Aldose Reductase Gene C(-106)T Polymorphism and Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects

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