Association of ADAM10 gene variants with sporadic Parkinson's disease in Chinese Han population

Abstract

Background Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. Genetic factors play important roles in PD risk. rs653765 and rs514049 of ADAM10 were reported to be associated with Alzheimer's disease (AD) in Caucasian population; however, the association of the two variants with PD in Chinese Han population remains unknown. The present investigation aimed to explore the possible association of ADAM10 variants with PD in Chinese Han population. Methods We enrolled 565 PD patients and 518 healthy controls to conduct a case–control study. DNA samples were extracted from peripheral blood leukocytes, and the genotypes were determined by utilization of MassARRAY platform. Plasma levels were measured by enzyme‐linked immunosorbent assay (ELISA). Results We found CC genotype of rs514049 was associated with an increased risk of PD (OR (95% CI) = 3.776 (1.127–11.217), p = 0.018). The C allele frequency of rs514049 was significantly higher in PD group (OR (95% CI) = 1.328 (1.031–1.709), p = 0.028), especially in male subgroup (OR (95% CI) = 1.484 (1.053–2.092), p = 0.024). However, there was no significant difference in the genotype or allele frequencies for rs653765 within the groups. Plasma levels were significantly decreased in PD patients compared with controls (p < 0.001). Conclusions Our data suggested that C allele of rs514049 in ADAM10 may increase the risk of PD in Chinese Han population, especially in males. The decreased plasma levels are probably involved in PD development.

Analysis of mRNA and Protein Levels of CAP2, DLG1 and ADAM10 Genes in Post-Mortem Brain of Schizophrenia, Parkinson’s and Alzheimer’s Disease Patients

“…It is noteworthy that even though our results show a remarkable decreasing tendency of CAP2 mRNA levels in the SFG of AD individuals, CAP2 protein levels were not affected, confirming the results obtained in previous studies [23]. CAP2 has never been analyzed in PD, while ADAM10 and SAP97 gene variants have already been associated with PD [57,58]. In the present work, we show a significant reduction of CAP2 mRNA levels in the SFG of the PD group, while no alterations in SAP97 and ADAM10 expression were detected in patients, compared to controls.…”

The Cytokine CX3CL1 and ADAMs/MMPs in Concerted Cross-Talk Influencing Neurodegenerative Diseases

“…Serum fraktaline is increased in the early stages of PD when motor disability is mild, but as the disease progresses, levels of this cytokine gradually decrease. Significantly, the declining levels correlated with progressive motor disability in patients with PD [63]. This may be because CX3CL1 levels are increased in the early stages of PD as a reflection of a protective antiinflammatory effect, so there is a high trend in the early stages of PD and progression as the disease progresses.…”