Association ofCaveolin-1polymorphisms with colorectal cancer susceptibility in Taiwan

Abstract

This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.

Functional polymorphisms of caveolin-1 variants as potential biomarkers of esophageal squamous cell carcinoma

“…There was no association between any of the other tested SNPs and ESCC risk. These results were consistent with other studies of CAV1 genetic polymorphism-related susceptibility to breast, colorectal and gastric cancers (Liu et al, 2011;Yang et al, 2010;Zhang et al, 2014). There was also an ethnic difference in the frequencies of genetic polymorphisms.…”

“…To date, many studies have explored the association of functional polymorphisms of CAV1 with the susceptibility to oral (Bau et al, 2011), breast (Liu et al, 2011), colorectal (Yang et al, 2010), gastric (Zhang et al, 2014) and hepatocellular (Hsu et al, 2013) cancers. For ESCC, several previous studies have reported clinical impact of CAV1 expression in esophageal carcinoma by immunohistochemical or cDNA expression array analysis, indicating a statistically significant increased expression of CAV1 mRNA and protein levels (Hu et al, 2001;Kato et al, 2002).…”

Genetic polymorphisms in caveolin-1 associate with breast cancer risk in Chinese Han population

“…A number of studies have explored the associations between CAV-1 genetic polymorphisms and the risk of various cancer types including hepatocellular carcinoma [ 13 ], gastric cancer [ 14 ], esophageal cancer [ 18 ], colorectal cancer [ 19 ], renal cell carcinoma [ 20 ], prostate cancer [ 15 ], bladder cancer [ 21 ] and leukemia [ 22 ]. We also found one study investigated the effect of CAV-1 SNPs on BC susceptibility by Liu et al In Liu’s study, they determined the six SNPs in CAV-1 (rs1997623, rs3807987, 12672038, rs3757733, rs7804372, and rs3807992) and assessed their association with BC risk.…”

Caveolin-1 Polymorphisms and Cancer risk in Asian: A Meta - Analysis

“…Figure 1 presents the detailed process of selecting and excluding studies. In the 13 articles, all studies were case-control studies with the following SNP distribution: 11 articles were about polymorphism rs1997623 [19][20][21][22][23][24][25][26][27][28][29], 11 articles were about rs12672038 [19][20][21][22][23][24][25][26][27][28][29], 10 articles were about rs3757733 [19,[21][22][23][24][25][26][27][28][29], 12 articles were about rs3807987 [18][19][20][21][22][23][24][25][26][27][28][29], 9 articles were about rs3807992 [18,19,[21][22]…”