Association of<i>CD58</i>Polymorphisms and its Protein Expression with the Development and Prognosis of Autoimmune Thyroid Diseases

Yamamoto, Masanori; Watanabe, Mikio; Inoue, Naohisa; Watanabe, Ayano; Ozaki, Haruka; Ohsaki, Mizuki; Hidaka, Yoh; Iwatani, Yoshinori

doi:10.1080/08820139.2019.1659811

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The rs2300747 A allele augments NMO risk by reducing the RNA expression of CD58. Furthermore, the percentage of CD58-positive monocytes is markedly lower in healthy controls with each of these risk genotypes of autoimmune thyroid diseases (AITDs), and lower in patients with Graves’ disease and Hashimoto’s disease, compared to healthy individuals ( 166 ). Therefore, CD58 SNPs may participate in AITD susceptibility by decreasing CD58 expression.…”

Section: Cd58 Polymorphismsmentioning

confidence: 99%

CD58 Immunobiology at a Glance

et al. 2021

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The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells. The CD2-CD58 interaction is an important component of the immunological synapse (IS) that induces activation and proliferation of T/NK cells and triggers a series of intracellular signaling in T/NK cells and target cells, respectively, in addition to promoting cell adhesion and recognition. Furthermore, a soluble form of CD58 (sCD58) is also present in cellular supernatant in vitro and in local tissues in vivo. The sCD58 is involved in T/NK cell-mediated immune responses as an immunosuppressive factor by affecting CD2-CD58 interaction. Altered accumulation of sCD58 may lead to immunosuppression of T/NK cells in the tumor microenvironment, allowing sCD58 as a novel immunotherapeutic target. Recently, the crucial roles of costimulatory molecule CD58 in immunomodulation seem to be reattracting the interests of investigators. In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a comprehensive summary of CD58 immunobiology.

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Section: Cd58 Polymorphismsmentioning

confidence: 99%

CD58 Immunobiology at a Glance

et al. 2021

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“…Americans and Hispanic Americans; rs724160030 is associated with nasolacrimal duct obstruction (14), rs647711 is associated with nasal features in Asian population (15), and CD58 SNPs are associated with autoimmune diseases and infections (16)(17)(18)(19). In light of these reports, and our results from the COPD-Gene cohort (of smokers with or without COPD), our data suggest that polymorphisms in the region of IGSF3 are not associated with emphysema; instead, they may contribute to increased risk of severe airway manifestations, such as COPD exacerbations and airway infections.…”

Section: Discussionmentioning

confidence: 99%

IGSF3 mutation identified in patient with severe COPD alters cell function and motility

et al. 2020

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“…Among HT patients, some develop hypothyroidism early in the disease, while others maintain normal thyroid function throughout life. [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility

Fang

Zhao

Zhuang

et al. 2022

International Journal of Endocrinology

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Purpose. Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. The purpose of this study was to investigate the potential relationship between polymorphism of the ANKRD55 gene and AITDs. Methods. For this study, we enrolled 2050 subjects, consisting of 1220 patients with AITD and 830 healthy subjects. Five loci (rs321776, rs191205, rs7731626, rs415407, and rs159572) of the ANKRD55 gene were genotyped using Multiplex PCR combined with high-throughput sequencing. Results. The results showed that the allele frequencies of rs7731626 and rs159572 loci in HT patients were lower than those in normal controls ( P = 0.048 and P = 0.03 , respectively). In different genetic model analyses, rs7731626 and rs159572 were also significantly correlated with HT in allele, dominant and additive models before and after age and sex adjustment. There were no differences in rs321776, rs191205, or rs415407 of the ANKRD55 gene in allele frequency or genotype frequency between AITDs patients and controls. Conclusions. This study for the first time found that rs7731626 and rs159572 of ANKRD55 were significantly correlated with HT, and individuals carrying the A allele at these two loci had a lower probability of developing HT.

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Association ofCD58Polymorphisms and its Protein Expression with the Development and Prognosis of Autoimmune Thyroid Diseases

Cited by 7 publications

References 27 publications

CD58 Immunobiology at a Glance

CD58 Immunobiology at a Glance

IGSF3 mutation identified in patient with severe COPD alters cell function and motility

Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility

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