Association of<i>Enterococcus</i>spp. with Severe Combat Extremity Injury, Intensive Care, and Polymicrobial Wound Infection

Heitkamp, Rae A; Li, Ping; Mende, Katrin; Demons, Samandra; Tribble, David R.; Tyner, Stuart D.

doi:10.1089/sur.2017.157

Cited by 31 publications

(18 citation statements)

References 55 publications

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“…Additionally, 3’SL and 6’SL induced moderate growth of Bifidobacteria and Bacteroides ( 57 ), two commensal bacteria known to be good for human health ( 58 – 60 ). Conversely, Enterococcus ( 61 ) and Streptococcus ( 62 ) are two bacteria that induce human infection. Other in vitro studies were conducted and demonstrated that HMOs are able to decrease the colonization ( 63 ) and growth ( 64 ) of group B Streptococcus .…”

Section: Hmos Promote the Proliferation Of Specific Intestinal Bacterial Strains And The Secretion Of Short-chain Fatty Acidsmentioning

confidence: 99%

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

et al. 2021

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Breastmilk is known to be very important for infants because it provides nutrients and immunological compounds. Among these compounds, human milk oligosaccharides (HMOs) represent the third most important component of breastmilk after lipids and lactose. Several experiments demonstrated the beneficial effects of these components on the microbiota, the immune system and epithelial barriers, which are three major biological systems. Indeed, HMOs induce bacterial colonization in the intestinal tract, which is beneficial for health. The gut bacteria can act directly and indirectly on the immune system by stimulating innate immunity and controlling inflammatory reactions and by inducing an adaptive immune response and a tolerogenic environment. In parallel, HMOs directly strengthen the intestinal epithelial barrier, protecting the host against pathogens. Here, we review the molecular mechanisms of HMOs in these different compartments and highlight their potential use as new therapeutic agents, especially in allergy prevention.

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Section: Hmos Promote the Proliferation Of Specific Intestinal Bacterial Strains And The Secretion Of Short-chain Fatty Acidsmentioning

confidence: 99%

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

et al. 2021

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“…The class of microorganisms known as ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa and Enterobacter sp.) are among the most prevalent bacteria in cutaneous infections [ 22 , 23 , 24 ]. The dynamics of bacterial infection of the skin are illustrated in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance

et al. 2021

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The skin is the largest organ in the human body, acting as a physical and immunological barrier against pathogenic microorganisms. The cutaneous lesions constitute a gateway for microbial contamination that can lead to chronic wounds and other invasive infections. Chronic wounds are considered as serious public health problems due the related social, psychological and economic consequences. The group of bacteria known as ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter sp.) are among the most prevalent bacteria in cutaneous infections. These pathogens have a high level of incidence in hospital environments and several strains present phenotypes of multidrug resistance. In this review, we discuss some important aspects of skin immunology and the involvement of ESKAPE in wound infections. First, we introduce some fundamental aspects of skin physiology and immunology related to cutaneous infections. Following this, the major virulence factors involved in colonization and tissue damage are highlighted, as well as the most frequently detected antimicrobial resistance genes. ESKAPE pathogens express several virulence determinants that overcome the skin’s physical and immunological barriers, enabling them to cause severe wound infections. The high ability these bacteria to acquire resistance is alarming, particularly in the hospital settings where immunocompromised individuals are exposed to these pathogens. Knowledge about the virulence and resistance markers of these species is important in order to develop new strategies to detect and treat their associated infections.

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“…As pesquisas apontam que entre as bactérias comumente isoladas nessas infecções, a Staphylococcus aureus lidera o número de casos, seguida pela Enterococcus faecium, Pseudomonas aeruginosa e Escherichia coli. Dessa forma, o tratamento mais adotado para essas infecções é a utilização de antimicrobianos (Heitkamp et al, 2018;Chaney et al, 2017).…”

Section: Introductionunclassified

Potencial antimicrobiano de óleos vegetais ozonizados frente a espécies bacterianas: uma revisão integrativa

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et al. 2021

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A crescente incidência de infecções bacterianas em lesões crônicas de pele é um problema mundial. Pesquisas sobre métodos terapêuticos alternativos, como utilização de óleos vegetais ozonizados, tornaram-se promissoras. Dessa forma, objetivou-se evidenciar a ação antimicrobiana de óleos vegetais ozonizados frente a estirpes bacterianas. Trata-se de uma revisão integrativa realizada através de buscas nas seguintes bases de dados e bibliotecas: Literatura Latino-Americana e do Caribe em Ciências da Saúde, Sistema Online de Busca e Análise de Literatura, Biblioteca Nacional de Medicina dos Estados Unidos, Biblioteca Eletrônica Científica Online e dois bancos de dados da Elsevier (Science Direct e Scopus). Foram selecionados 11 artigos, 73% desses trabalhos foram publicados nos últimos 5 anos, enquanto apenas 27% foram publicados nos anos de 2011 e 2013. Houveram publicações da China, Itália, Brasil, Cuba, França e Turquia. Todos os trabalhos utilizaram métodos laboratoriais para avaliar o potencial antimicrobiano do óleo vegetal ozonizado. O efeito antibacteriano dos óleos relacionou-se às condições de ozonização que foram submetidos e sua composição final de peróxidos e ácidos carboxílicos. Verificou-se que esses compostos promoveram alterações celulares e impediram crescimento bacteriano, podendo induzir morte bacteriana. Através dessa revisão foi possível apresentar informações atualizadas sobre uma alternativa terapêutica promissora contra infecções bacterianas na pele.

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Association ofEnterococcusspp. with Severe Combat Extremity Injury, Intensive Care, and Polymicrobial Wound Infection

Cited by 31 publications

References 55 publications

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance

Potencial antimicrobiano de óleos vegetais ozonizados frente a espécies bacterianas: uma revisão integrativa

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