Association of<i>EZH2</i>Genotypes With Oral Cancer Risk

Shih, Liang‐Chun; Tsai, Chia-Wen; Lin, Tzeng‐Jih; Wang, Yun-Chi; He, Jie-Long; Hsu, Chiao‐Po; Hsia, Te‐Chun; Tsai, Fuu‐Jen; Yang, Jai Sing; Hsu, Yu-Ting; Bau, Da‐Tian; Chang, Wen‐Yu

doi:10.21873/invivo.13002

Cited by 1 publication

(1 citation statement)

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“…MMP-2 rs243865 and rs2285053 genotyping. DNA was extracted from the whole blood of each participant as previously published (40)(41)(42). In the present study, the profiles of MMP-2 rs243865 and rs2285053 genotypes among 218 PCa and 436 controls were determined by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.…”

Section: Methodsmentioning

confidence: 99%

Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk

Liao

Huang

et al. 2022

Anticancer Res

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Background/Aim: Prostate cancer is one of the most commonly diagnosed malignancies among males, especially in Western populations. Matrix metalloproteinase-2 (MMP-2) plays a critical role in extracellular regulation and metastasis. However, its genotypes have seldom been examined among patients with prostate cancer (PCa). Therefore, the purpose of the study was to evaluate the association of genotypes at MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) with PCa risk in a Taiwanese cohort. Materials and Methods: The profiles of MMP-2 rs243865 and rs2285053 genotypes were examined among 218 PCa patients and 436 healthy controls by polymerase chain reaction-restriction fragment length polymorphism methodologies. Results: The percentages of wildtype CC, and variant CT and TT genotypes on MMP-2 rs243865 were 88.5, 10.6, and 0.9% in the PCa case group and 85.6, 13.5, and 0.9% in the control group, respectively (p for trend=0.5544). The allelic frequency distribution showed that the variant T allele at MMP-2 rs24386 5 was not associated with PCa risk (p=0.3250). As for MMP-2 rs2285053, the results were also non-significant. In addition, there was no association between the genotypes of MMP-2 rs243865 or rs2285053 with age or smoking status on PCa risk. Conclusion: rs11568818 and rs11568819 at MMP-2 promoter region played minor roles in determining individual PCa risk.Prostate cancer (PCa) is the second most prevalent malignancy, and the fifth leading death-causing cancer among males worldwide, with about 1,414,000 newly diagnosed cases and 375,304 deaths in 2020 (1). According to global cancer statistics, PCa is the most frequently diagnosed cancer in 112 countries, and the leading death-causing malignancy in 48 countries including USA (2). According to world cancer statistics, PCa cases are predicted to continue to increase due to the trend of global aging (3). From the epidemiological viewpoint, black race, family cancer history, and aging, are three most well-known risk factors for PCa (4). In addition, fitness (5), diabetes mellitus (6), obesity (7), risky diet (8), and over-supplementation of vitamin E (9) may also contribute to the etiology of PCa. However, lack of targets in PCa therapy urge the identification of genetic markers.The extracellular matrix (ECM) is a meshwork of crosslinked macromolecules that form a dynamic scaffold outside of the cells. It provides homeostasis of the micro-environment, and its imbalances may associate with cancer progression and metastasis (10,11). Noticeably, matrix metalloproteinases (MMPs, also named matrix metallopeptidases or matrixins) play 343 *These Authors contributed equally to this study.

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Section: Methodsmentioning

confidence: 99%